A comparison of 2 ‐hydroxyglutarate detection at 3 and 7 T with long‐TE semi‐LASER

In this study, a comparison using semi‐localization by adiabatic selective refocusing (semi‐LASER) (TE = 110 ms) at 3 T and 7 T reveals significantly improved 2‐HG Cramér–Rao lower bounds (CRLBs) in patients with glioma, together with improvement in the pairwise fitting correlation with γ‐aminobutyric acid (GABA) at 7 T. The superior spectral profile at 7 T allowed for the detection (CRLB < 20%) of 2‐HG after two acquired transients compared with ~64 at 3 T.

Source: NMR in Biomedicine - January 1, 2018 Category: Radiology Authors: Adam Berrington, Natalie L. Voets, Sarah J. Larkin, Nick Pennington, James Mccullagh, Richard Stacey, Christopher J. Schofield, Peter Jezzard, Stuart Clare, Tom Cadoux ‐Hudson, Puneet Plaha, Olaf Ansorge, Uzay E. Emir Tags: RAPID COMMUNICATION Source Type: research