Comparison of metabolic adaptations between endurance ‐ and sprint‐trained athletes after an exhaustive exercise in two different calf muscles using a multi‐slice 31P‐MR spectroscopic sequence
In conclusion, we were able to analyze the relation between specific local metabolic processes in loaded muscles and typical global adaptation parameters, conventionally used to monitor the training status of athletes, in two cohorts with different sports orientations.
The effects of different training strategies were resolved by simultaneous monitoring of load‐induced changes of high‐energy phosphates and pH values in multiple muscle groups revealing heterogeneous metabolic adaptations. In addition these results were linked to global physiological regulations, which are commonly used to monitor the training status of...
Source: NMR in Biomedicine - February 1, 2018 Category: Radiology Authors: Kevin Moll, Alexander Gussew, Maria Nisser, Steffen Derlien, Martin Kr ämer, Jürgen R. Reichenbach Tags: RESEARCH ARTICLE Source Type: research
Multi ‐compartmental diffusion characterization of the human cervical spinal cord in vivo using the spherical mean technique
The purpose of this work was to evaluate the feasibility and reproducibility of the spherical mean technique (SMT), a multi‐compartmental diffusion model, in the spinal cord of healthy controls, and to assess its ability to improve spinal cord characterization in multiple sclerosis (MS) patients at 3 T. SMT was applied in the cervical spinal cord of eight controls and six relapsing‐remitting MS patients. SMT provides an elegant framework to model the apparent axonal volume fraction vax, intrinsic diffusivity Dax, and extra‐axonal transverse diffusivity Dex_perp (which is estimated as a function of vax and Dax) witho...
Source: NMR in Biomedicine - February 1, 2018 Category: Radiology Authors: Samantha By, Junzhong Xu, Bailey A. Box, Francesca R. Bagnato, Seth A. Smith Tags: RESEARCH ARTICLE Source Type: research
Increased hyperpolarized [1 ‐13C] lactate production in a model of joint inflammation is not accompanied by tissue acidosis as assessed using hyperpolarized 13C‐labelled bicarbonate
Arthritic conditions are a major source of chronic pain. Furthering our understanding of disease mechanisms creates the opportunity to develop more targeted therapeutics. In rheumatoid arthritis (RA), measurements of pH in human synovial fluid suggest that acidosis occurs, but that this is highly variable between individuals. Here we sought to determine if tissue acidosis occurs in a widely used rodent arthritis model: complete Freund's adjuvant (CFA)‐induced inflammation. CFA robustly evoked paw and ankle swelling, concomitant with worsening clinical scores over time. We used magnetic resonance spectroscopic imaging of ...
Source: NMR in Biomedicine - January 30, 2018 Category: Radiology Authors: Alan J. Wright, Zo é M.A. Husson, De‐En Hu, Gerard Callejo, Kevin M. Brindle, Ewan St. John Smith Tags: RESEARCH ARTICLE Source Type: research
Increased hyperpolarized [1 ‐13C] lactate production in a model of joint inflammation is not accompanied by tissue acidosis as assessed using hyperpolarized 13C‐labelled bicarbonate
NMR in Biomedicine,Volume 31, Issue 4, April 2018. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - January 30, 2018 Category: Radiology Source Type: research
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NMR in Biomedicine,Volume 31, Issue 4, April 2018. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - January 30, 2018 Category: Radiology Source Type: research
Snapshot ‐CEST: Optimizing spiral‐centric‐reordered gradient echo acquisition for fast and robust 3D CEST MRI at 9.4 T
Gradient echo (GRE)‐based acquisition provides a robust readout method for chemical exchange saturation transfer (CEST) at ultrahigh field (UHF). To develop a snapshot‐CEST approach, the transient GRE signal and point spread function were investigated in detail, leading to optimized measurement parameters and reordering schemes for fast and robust volumetric CEST imaging. Simulation of the transient GRE signal was used to determine the optimal sequence parameters and the maximum feasible number of k‐space lines. Point spread function analysis provided an insight into the induced k‐space filtering and the performanc...
Source: NMR in Biomedicine - January 26, 2018 Category: Radiology Authors: Moritz Zaiss, Philipp Ehses, Klaus Scheffler Tags: RESEARCH ARTICLE Source Type: research
Snapshot ‐CEST: Optimizing spiral‐centric‐reordered gradient echo acquisition for fast and robust 3D CEST MRI at 9.4 T
NMR in Biomedicine,Volume 31, Issue 4, April 2018. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - January 26, 2018 Category: Radiology Source Type: research
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NMR in Biomedicine,Volume 31, Issue 4, April 2018. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - January 26, 2018 Category: Radiology Source Type: research
Chasing N ‐acetyl‐L‐aspartate, a shiny NMR object in the brain
(Source: NMR in Biomedicine)
Source: NMR in Biomedicine - January 25, 2018 Category: Radiology Authors: Morris H. Baslow Tags: LETTER TO THE EDITOR Source Type: research
Magnetic resonance elastography of liver and spleen: Methods and applications
NMR in Biomedicine, EarlyView. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - January 25, 2018 Category: Radiology Source Type: research
Chasing N ‐acetyl‐L‐aspartate, a shiny NMR object in the brain
NMR in Biomedicine,Volume 31, Issue 4, April 2018. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - January 25, 2018 Category: Radiology Source Type: research
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NMR in Biomedicine, Ahead of Print. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - January 25, 2018 Category: Radiology Source Type: research
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NMR in Biomedicine,Volume 31, Issue 4, April 2018. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - January 25, 2018 Category: Radiology Source Type: research
Magnetic resonance elastography of liver and spleen: Methods and applications
The viscoelastic properties of the liver and spleen can be assessed with magnetic resonance elastography (MRE). Several actuators, MRI acquisition sequences and reconstruction algorithms have been proposed for this purpose. Reproducible results are obtained, especially when the examination is performed in standard conditions with the patient fasting. Accurate staging of liver fibrosis can be obtained by measuring liver stiffness or elasticity with MRE. Moreover, emerging evidence shows that assessing the tissue viscous parameters with MRE is useful for characterizing liver inflammation, non‐alcoholic steatohepatitis, hep...
Source: NMR in Biomedicine - January 25, 2018 Category: Radiology Authors: Philippe Garteiser, Sabrina Doblas, Bernard E. Van Beers Tags: SPECIAL ISSUE REVIEW ARTICLE Source Type: research
From micro ‐ to macro‐structures in multiple sclerosis: what is the added value of diffusion imaging
Conclusions from the literature are that larger studies are needed to confirm the exciting results from initial investigations before current trends in diffusion imaging can be translated to the neurology clinic. Also, for a comprehensive understanding of pathological processes, it is essential to take a multiple‐level approach, in which information at the micro‐, meso‐ and macroscopic scales is fully integrated.
Diffusion in multiple sclerosis (MS) can provide information about the microstructure, but this might not be sufficient to explain clinical disability: the functional system impairment might emerge only whe...
Source: NMR in Biomedicine - January 19, 2018 Category: Radiology Authors: Mara Cercignani, Claudia Gandini Wheeler ‐Kingshott Tags: SPECIAL ISSUE REVIEW ARTICLE Source Type: research
