---
NMR in Biomedicine, Ahead of Print. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - September 25, 2017 Category: Radiology Source Type: research
In vivo MRS for the assessment of mouse colon using a dedicated endorectal coil: initial findings
Inflammatory bowel disease is a common group of inflammation conditions that can affect the colon and the rectum. These pathologies require a careful follow‐up of patients to prevent the development of colorectal cancer. Currently, conventional endoscopy is used to depict alterations of the intestinal walls, and biopsies are performed on suspicious lesions for further analysis (histology). MRS enables the in vivo analysis of biochemical content of tissues (i.e. without removing any samples). Combined with dedicated endorectal coils (ERCs), MRS provides new ways of characterizing alterations of tissues.
An MRS in vivo pro...
Source: NMR in Biomedicine - September 25, 2017 Category: Radiology Authors: Hugo Dorez, H élène Ratiney, Laurence Canaple, Hervé Saint‐Jalmes, Sophie Gaillard, Driffa Moussata, Raphaël Sablong, Olivier Beuf Tags: RESEARCH ARTICLE Source Type: research
Simultaneous detection of glutathione and lactate using spectral editing at 3 T
Two spectral editing techniques for the simultaneous detection of glutathione (GSH) and lactate (Lac) in the human brain at 3 T are described and evaluated. These methods, ‘sMEGA’ (sinc‐MEscher and GArwood) and ‘DEW’ (Double Editing With), were optimized to detect GSH and Lac simultaneously at 3 T using density‐matrix simulations and validation in phantoms. Simulations to test for co‐edited metabolites within the detected GSH region of the spectrum were also performed. In vivo data were acquired in the midline parietal region of seven subjects using both methods, and compared with conventional MEGA‐PRESS ...
Source: NMR in Biomedicine - September 22, 2017 Category: Radiology Authors: Kimberly L. Chan, Karim Snoussi, Richard A.E. Edden, Peter B. Barker Tags: RESEARCH ARTICLE Source Type: research
Region ‐specific impairment of the cervical spinal cord (SC) in amyotrophic lateral sclerosis: A preliminary study using SC templates and quantitative MRI (diffusion tensor imaging/inhomogeneous magnetization transfer)
In this study, in addition to an important SC WM demyelination, we also observed, for the first time in ALS, impairments of cervical aGM.
A high‐resolution, multi‐parametric magnetic resonance (MR) protocol, including diffusion tensor imaging and inhomogeneous magnetization transfer imaging, was combined with an atlas‐based analysis using dedicated spinal cord templates to evaluate region‐specific impairments of the cervical spinal cord in amyotrophic lateral sclerosis (ALS). The preliminary results suggested that this high‐resolution, multi‐parametric MR protocol is valuable for the characterization of spinal...
Source: NMR in Biomedicine - September 19, 2017 Category: Radiology Authors: Henitsoa Rasoanandrianina, Aude ‐Marie Grapperon, Manuel Taso, Olivier M. Girard, Guillaume Duhamel, Maxime Guye, Jean‐Philippe Ranjeva, Shahram Attarian, Annie Verschueren, Virginie Callot Tags: RESEARCH ARTICLE Source Type: research
DCE ‐ and DW‐MRI as early imaging biomarkers of treatment response in a preclinical model of triple negative breast cancer
This study evaluates quantitative dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) and diffusion‐weighted MRI (DW‐MRI) parameters as early biomarkers of response in a preclinical model of triple negative breast cancer. Results from quantitative imaging with histological validation indicate that the apparent diffusion coefficient (ADC) and volume transfer constant (Ktrans) have the potential to serve as early biomarkers of treatment response to Abraxane chemotherapy in murine studies of MDA‐MB‐231 tumors. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - September 15, 2017 Category: Radiology Authors: Stephanie L. Barnes, Anna G. Sorace, Jennifer G. Whisenant, J. Oliver McIntyre, Hakmook Kang, Thomas E. Yankeelov Tags: RESEARCH ARTICLE Source Type: research
