DCE ‐ and DW‐MRI as early imaging biomarkers of treatment response in a preclinical model of triple negative breast cancer
This study evaluates quantitative dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) and diffusion‐weighted MRI (DW‐MRI) parameters as early biomarkers of response in a preclinical model of triple negative breast cancer. Results from quantitative imaging with histological validation indicate that the apparent diffusion coefficient (ADC) and volume transfer constant (Ktrans) have the potential to serve as early biomarkers of treatment response to Abraxane chemotherapy in murine studies of MDA‐MB‐231 tumors.
Source: NMR in Biomedicine - Category: Radiology Authors: Stephanie L. Barnes, Anna G. Sorace, Jennifer G. Whisenant, J. Oliver McIntyre, Hakmook Kang, Thomas E. Yankeelov Tags: RESEARCH ARTICLE Source Type: research
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