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NMR in Biomedicine, Ahead of Print. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - March 1, 2018 Category: Radiology Source Type: research
Neonatal hyperglycemia alters the neurochemical profile, dendritic arborization and gene expression in the developing rat hippocampus
Hyperglycemia (blood glucose concentration >150 mg/dL) is common in extremely low gestational age newborns (ELGANs; birth at <28 week gestation). Hyperglycemia increases the risk of brain injury in the neonatal period. The long‐term effects are not well understood. In adult rats, hyperglycemia alters hippocampal energy metabolism. The effects of hyperglycemia on the developing hippocampus were studied in rat pups. In Experiment 1, recurrent hyperglycemia of graded severity (moderate hyperglycemia (moderate‐HG), mean blood glucose 214.6 ± 11.6 mg/dL; severe hyperglycemia (severe‐HG), 338.9 ± 21.7 mg/dL; co...
Source: NMR in Biomedicine - March 1, 2018 Category: Radiology Authors: Raghavendra Rao, Motaz Nashawaty, Saher Fatima, Kathleen Ennis, Ivan Tkac Tags: RESEARCH ARTICLE Source Type: research
Accelerated phase contrast MRI using hybrid one ‐ and two‐sided flow encodings only (HOTFEO)
The aim of this work was to develop and evaluate a fast phase contrast magnetic resonance imaging (PC‐MRI) technique with hybrid one‐ and two‐sided flow encodings only (HOTFEO) for accurate blood flow and velocity measurements of three‐directional velocity encoding PC‐MRI. Four‐dimensional (4D) PC‐MRI acquires flow‐compensated (FC) and three‐directional flow‐encoded (FE) echoes in an interleaved fashion. We hypothesize that the blood flow velocity direction (not magnitude) has minimal change between two consecutive cardiac phases. This assumption provides a velocity direction constraint that can achieve...
Source: NMR in Biomedicine - March 1, 2018 Category: Radiology Authors: Da Wang, Aichi Chien, Jiaxin Shao, Fadil Abbas Ali, Peng Hu Tags: RESEARCH ARTICLE Source Type: research
Cranial irradiation increases tumor growth in experimental breast cancer brain metastasis
Whole‐brain radiotherapy is the standard of care for patients with breast cancer with multiple brain metastases and, although this treatment has been essential in the management of existing brain tumors, there are many known negative consequences associated with the irradiation of normal brain tissue. In our study, we used in vivo magnetic resonance imaging analysis to investigate the influence of radiotherapy‐induced damage of healthy brain on the arrest and growth of metastatic breast cancer cells in a mouse model of breast cancer brain metastasis. We observed that irradiated, but otherwise healthy, neural tissue had...
Source: NMR in Biomedicine - March 1, 2018 Category: Radiology Authors: Amanda M. Hamilton, Suzanne M. Wong, Eugene Wong, Paula J. Foster Tags: RESEARCH ARTICLE Source Type: research
An Overhauser ‐enhanced‐MRI platform for dynamic free radical imaging in vivo
Overhauser‐enhanced MRI (OMRI) is an electron‐proton double‐resonance imaging technique of interest for its ability to non‐invasively measure the concentration and distribution of free radicals. In vivo OMRI experiments are typically undertaken at ultra‐low magnetic field (ULF), as both RF power absorption and penetration issues—a consequence of the high resonance frequencies of electron spins—are mitigated. However, working at ULF causes a drastic reduction in MRI sensitivity. Here, we report on the design, construction and performance of an OMRI platform optimized for high NMR sensitivity and low RF power a...
Source: NMR in Biomedicine - March 1, 2018 Category: Radiology Authors: David E. J. Waddington, Mathieu Sarracanie, Najat Salameh, Fanny Herisson, Cenk Ayata, Matthew S. Rosen Tags: RESEARCH ARTICLE Source Type: research
Diffusion MRI visualization
This article provides an overview of visualization solutions that have been proposed to date, ranging from basic grayscale and color encodings to glyph representations and renderings of fiber tractography. A particular focus is on ongoing and possible future developments in dMRI visualization, including comparative, uncertainty, interactive and dense visualizations.
This paper provides an overview of visualization solutions that have been proposed to date for diffusion MRI, ranging from basic grayscale and color encodings to glyph representations and renderings of fiber tractography. A particular focus is on ongoing and p...
Source: NMR in Biomedicine - February 27, 2018 Category: Radiology Authors: Thomas Schultz, Anna Vilanova Tags: SPECIAL ISSUE REVIEW ARTICLE Source Type: research
Diffusion MRI visualization
NMR in Biomedicine, EarlyView. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - February 27, 2018 Category: Radiology Source Type: research
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NMR in Biomedicine, Ahead of Print. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - February 27, 2018 Category: Radiology Source Type: research
Bi ‐exponential 23Na T2* component analysis in the human brain
The purpose of this study was to measure the sodium transverse relaxation time T2* in the healthy human brain. Five healthy subjects were scanned with 18 echo times (TEs) as short as 0.17 ms. T2* values were fitted on a voxel‐by‐voxel basis using a bi‐exponential model. Data were also analysed using a continuous distribution fit with a region of interest‐based inverse Laplace transform. Average T2* values were 3.4 ± 0.2 ms and 23.5 ± 1.8 ms in white matter (WM) for the short and long components, respectively, and 3.9 ± 0.5 ms and 26.3 ± 2.6 ms in grey matter (GM) for the short and long components, respecti...
Source: NMR in Biomedicine - February 26, 2018 Category: Radiology Authors: Frank Riemer, Bhavana S. Solanky, Claudia A.M. Wheeler ‐Kingshott, Xavier Golay Tags: RESEARCH ARTICLE Source Type: research
Bi ‐exponential 23Na T2* component analysis in the human brain
NMR in Biomedicine, EarlyView. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - February 26, 2018 Category: Radiology Source Type: research
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NMR in Biomedicine, Ahead of Print. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - February 26, 2018 Category: Radiology Source Type: research
Quantitative magnetic resonance spectroscopy at 3T based on the principle of reciprocity
Quantification of magnetic resonance spectroscopy signals using the phantom replacement method requires an adequate correction of differences between the acquisition of the reference signal in the phantom and the measurement in vivo. Applying the principle of reciprocity, sensitivity differences can be corrected at low field strength by measuring the RF transmitter gain needed to obtain a certain flip angle in the measured volume. However, at higher field strength the transmit sensitivity may vary from the reception sensitivity, which leads to wrongly estimated concentrations. To address this issue, a quantification approa...
Source: NMR in Biomedicine - February 21, 2018 Category: Radiology Authors: Niklaus Zoelch, Andreas Hock, Anke Henning Tags: RESEARCH ARTICLE Source Type: research
Quantitative magnetic resonance spectroscopy at 3T based on the principle of reciprocity
NMR in Biomedicine, EarlyView. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - February 21, 2018 Category: Radiology Source Type: research
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NMR in Biomedicine, Ahead of Print. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - February 21, 2018 Category: Radiology Source Type: research
