The effects of ageing on mouse muscle microstructure: a comparative study of time ‐dependent diffusion MRI and histological assessment

In this study, we investigated hind‐limb muscles of young growing and mature healthy mice using diffusion‐weighted imaging protocols and histology. Imaging findings showed that muscle water diffusivity decreased with increasing mouse age both in vivo and in vitro. However, muscle fibre size was larger in older mice, whereas the extracellular matrix decreased with age. This suggests that muscle water diffusivity may be driven by different sarcolemma‐associated properties between actively growing myofibres and adult myofibres in homeostasis.
Source: NMR in Biomedicine - Category: Radiology Authors: Tags: EDITOR ’S PICK Source Type: research