Mutation Research Genetic Toxicology and Environmental Mutagenesis This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Recommended Criteria for the Evaluation of Bacterial Mutagenicity Data (Ames Test)
Publication date: Available online 5 August 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Dan D. Levy, Errol Zeiger, Patricia Escobar, Atsushi Hakura, Bas-jan M. van der Leede, Masayuki Kato, Martha M. Moore, Kei-ichi SugiyamaAbstractA committee was constituted within the International Workshop on Genetic Toxicology Testing (IWGT) to evaluate the current criteria for a valid Ames test and to provide recommendations for interpretation of test results. Currently, determination of a positive vs. a negative result is made by applying various data evaluation procedures for comparing do...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - August 7, 2019 Category: Genetics & Stem Cells Source Type: research

Loss of genetic integrity in artificially aged seed lots of rice (Oryza sativa L.) and common bean (Phaseolus vulgaris L.)
Publication date: Available online 1 August 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Alisson F. Dantas, Maria L. Fascineli, Solange C.B.R. José, Juliano G. Pádua, Marcos A. Gimenes, Cesar K. GrisoliaABSTRACTLoss of genetic integrity can occur during the long-term conservation of seeds. We have studied these effects in seeds of rice (Oryza sativa L.) and common bean (Phaseolus vulgaris L.) exposed to accelerated aging (elevated temperature and moisture) conditions. Tests of first count, germination, and germination speed index were performed to measure physiological quality;...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - August 2, 2019 Category: Genetics & Stem Cells Source Type: research

Antigenotoxic and antioxidant potential of medicinal mushrooms (Immune Assist) against DNA damage induced by free radicals-an in vitro study
Publication date: Available online 1 August 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Lada Živković, Vladan Bajić, Marija Bruić, Sunčica Borozan, Kristina Popić, Dijana Topalović, Juan Santibanez, Biljana Spremo-PotparevićAbstractImmune Assist (IA) is produced from extract of six species of medical mushrooms: Agaricus blazei - Cordyceps sinensis - Grifola frondosa - Ganoderma lucidum - Coriolus versicolor - Lentinula edodes. The genoprotective potential of IA was evaluated for the first time. Significant antigenotoxic effects were detected in human peripheral blood cel...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - August 2, 2019 Category: Genetics & Stem Cells Source Type: research

DNA damage from long-term occupational exposure to extremely low frequency electromagnetic fields among power plant workers
Publication date: Available online 29 July 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Majid Bagheri Hosseinabadi, Narges Khanjani, Mehdi Mirzaii, Pirasteh Norouzi, Amir AtashiAbstractExtremely low frequency electromagnetic fields (ELF-EMFs) are not known as definite occupational carcinogens, but some studies have reported the genotoxic effects of these fields on cell lines. The present study aimed to evaluate the effects of long-term occupational exposure to these fields on DNA damage. In this cross-sectional study, blood samples were taken from 102 thermal power plant workers ...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - July 29, 2019 Category: Genetics & Stem Cells Source Type: research

Metal ions modify DNA-protecting and mutagen-scavenging capacities of the AV-153 1,4-dihydropyridine
Publication date: Available online 24 July 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Elina Leonova, Kristīne Ošiņa, Gunars Duburs, Egils Bisenieks, Diego Germini, Yegor Vassetzky, Nikolajs SjaksteAbstract1,4-dihydropyridines (1,4-DHP) possess important biochemical and pharmacological properties, including antioxidant and antimutagenic activities. AV-153-Na, an antimutagenic and DNA-repair enhancing compound was shown to interact with DNA by intercalation. Here we studied DNA binding of several AV-153 salts to evaluate the impact of AV-153 modifications on its DNA binding ca...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - July 25, 2019 Category: Genetics & Stem Cells Source Type: research

Dietary hemin promotes colonic preneoplastic lesions and DNA damage but not tumor development in a medium-term model of colon carcinogenesis in rats
Publication date: Available online 18 July 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Nelci A. de Moura, Brunno F.R. Caetano, Lucas T. Bidinotto, Maria A.M. Rodrigues, Luis F. BarbisanAbstractRed and processed meat consumption has been strongly related to increase the risk of colorectal cancer (CRC), although its impact is largely unknown. Hemin, an iron-containing porphyrin, is acknowledged as a putative factor of red and processed meat pro-carcinogenic effects. The aim of this study was to investigate the effects of high dietary hemin on the promotion/progression stages of 1,...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - July 19, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: August 2019Source: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 844Author(s): (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - July 19, 2019 Category: Genetics & Stem Cells Source Type: research

Demonstrating laboratory proficiency in bacterial mutagenicity assays for regulatory submission
Publication date: Available online 12 July 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Dan D. Levy, Atsushi Hakura, Rosalie K. Elespuru, Patricia A. Escobar, Masayuki Kato, Jasmin Lott, Martha M. Moore, Kei-ichi SugiyamaAbstractThe bacterial reverse mutation test is a mainstay for evaluation of mutagenicity predicting the carcinogenic potential of a test substance and is recommended by regulatory agencies across the globe. The popularity of the test is due, in part, to the relatively low cost, rapid results and small amount of test material required compared to most other toxico...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - July 13, 2019 Category: Genetics & Stem Cells Source Type: research

Inflammation and DNA damage induction in surgical patients maintained with desflurane anesthesia
In conclusion, anesthetic maintenance with the modern agent desflurane during minor surgeries led to genotoxic and inflammatory effects without altering the expression of inflammation related-genes the day after surgery in patients without comorbidities. (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - July 11, 2019 Category: Genetics & Stem Cells Source Type: research

Adventures with Bruce Ames and the Ames Test
Publication date: Available online 4 July 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Lawrence J. MarnettAbstractBruce Ames has had an enormous impact on human health by developing facile methods for the identification of mutagens. This research also provided important insights into the relationship between mutagenesis and carcinogenesis. Bruce is a highly innovative and creative individual who has followed his interests across disciplines into diverse fields of inquiry. The present author had the pleasure of spending a sabbatical in the Ames lab and utilized the Ames test in mu...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - July 5, 2019 Category: Genetics & Stem Cells Source Type: research

Comet assay in vitro
Publication date: Available online 3 July 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Maria Dusinska, Solange Costa, Andrew Collins (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - July 4, 2019 Category: Genetics & Stem Cells Source Type: research

Integration of Micronucleus, Comet, and Pig-a Gene Mutation Endpoints into Rat 15-day Repeat-treatment Studies: Proof-of-principle with Auramine O
In conclusion, using a multiple-endpoint genotoxicity assay method can reduce the number of experimental animals, boost the efficiency of the experiment, and improve the accuracy of investigations of genotoxicity. (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - July 4, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: June 2019Source: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 842Author(s): (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - June 27, 2019 Category: Genetics & Stem Cells Source Type: research

Comet assay genotoxicity evaluation of occupationally exposed tea-garden workers in northern West Bengal, India
Publication date: Available online 18 June 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Susmita Dutta, Min BahadurAbstractTo assess possible genotoxic effects of pesticide exposure in occupationally exposed tea-garden workers, DNA damage in peripheral blood lymphocytes was evaluated with the comet assay. The effects of smoking and alcohol consumption were also examined. The comet tail length, % tail DNA, and Olive tail moment were significantly higher in pesticide-exposed workers compared to non-exposed controls. None of the damage parameters differed when control smokers and con...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - June 19, 2019 Category: Genetics & Stem Cells Source Type: research

DNA-Damaging Activities of Twenty-Four Structurally Diverse Unsubstituted and Substituted Cyclic Compounds in Embryo-Fetal Chicken Livers
Publication date: Available online 14 June 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Tetyana Kobets, Jian-Dong Duan, Klaus D. Brunnemann, Esther Vock, Ulrich Deschl, Gary M. WilliamsAbstractDNA-damaging activities of twenty-four structurally diverse unsubstituted and substituted cyclic compounds were assessed in embryo-fetal chicken livers. Formation of DNA adducts and strand breaks were measured using the nucleotide 32P-postlabelling (NPL) and comet assays, respectively. Unsubstituted monocyclic benzene, polycyclic fused ring compound naphthalene, covalently connected polycyc...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - June 15, 2019 Category: Genetics & Stem Cells Source Type: research