Mutation Research Genetic Toxicology and Environmental Mutagenesis This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

In vivo genotoxicity testing strategies: Report from the 7th International Workshop on Genotoxicity Testing (IWGT)
Publication date: Available online 25 April 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): David Kirkland, Yoshifumi Uno, Mirjam Luijten, Carol Beevers, Jan van Benthem, Brian Burlinson, Stephen Dertinger, George R. Douglas, Shuichi Hamada, Katsuyoshi Horibata, David P. Lovell, Mugimane Manjanatha, Hans-Joerg Martus, Nan Mei, Takeshi Morita, Wakako Ohyama, Andrew WilliamsAbstractThe working group reached complete or majority agreement on many issues.Results from TGR and in vivo comet assays for 91 chemicals showed they have similar ability to detect in vivo genotoxicity per se with...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - April 27, 2019 Category: Genetics & Stem Cells Source Type: research

A Perspective on the Development of the Ames Salmonella/Mammalian Microsome Mutagenicity Assay
Publication date: Available online 20 April 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Kristien Mortelmans (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - April 20, 2019 Category: Genetics & Stem Cells Source Type: research

In Vitro Mammalian Cell Mutation Assays Based On Transgenic Reporters: a Report of the International Workshop on Genotoxicity Testing (IWGT)
Publication date: Available online 13 April 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Paul A. White, Mirjam Luijten, Masayuki Mishima, Julie A. Cox, Joleen Hanna, Rebecca Maertens, Edwin P. ZwartAbstractChemical safety evaluations require assessment of genetic toxicity. Transgenic rodent (TGR) assays permit enumeration of mutations in chromosomally-integrated targets contained in shuttle vectors. In order to improve in vitro mutagenicity assessment, and to substantially reduce animal use, in vitro assays using transgenic reporters have been developed. These assays are based on...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - April 14, 2019 Category: Genetics & Stem Cells Source Type: research

Biomarkers of DNA damage in COPD patients undergoing pulmonary rehabilitation: Integrating clinical parameters with genomic profiling
Publication date: Available online 12 April 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Patrizia Russo, Palma Lamonaca, Mirta Milic, Emilio Rojas, Giulia Prinzi, Vittorio Cardaci, LauraVitiello, Stefania Proietti, Alessia Santoro, Massimo Fini, Stefano BonassiAbstractChronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by severe respiratory symptoms. COPD shows several hallmarks of aging, and an increased oxidative stress, which is responsible for different clinical and molecular COPD features, including an increased frequency of DNA damage. T...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - April 13, 2019 Category: Genetics & Stem Cells Source Type: research

Lymphocytes exposed to vegetables grown in waters contaminated by anticancer drugs: metabolome alterations and genotoxic risks for human health
Publication date: Available online 3 April 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Chiara Russo, Vittoria Graziani, Margherita Lavorgna, Brigida D’Abrosca, Concetta Piscitelli, Antonio Fiorentino, Monica Scognamiglio, Marina IsidoriAbstractWastewater irrigation of crops may be effective to avoid depletion (about 70%) of freshwater resources. However, the use of reclaimed waters containing persistent microcontaminants such as antineoplastic drugs is of high environmental concern. These active compounds may affect human health with potentially severe adverse effects. To bett...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - April 5, 2019 Category: Genetics & Stem Cells Source Type: research

Isolation of leukocytes from frozen buffy coat for comet assay analysis of DNA damage
Publication date: Available online 31 March 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Siv Kjølsrud Bøhn, Vaineta Vebraite, Sergey Shaposhnikov, Andrew R. CollinsAbstractFrozen buffy coat fractions are often stored in human biomonitoring trials but their use for biomarker purposes has been limited. The purpose of the current study was to study whether frozen buffy coats can be used to monitor DNA damage levels.EDTA blood samples were provided from 9 healthy, non-smoking female volunteers, aged 26-48. Pre-existing DNA damage (strand breaks and oxidised purines) was measured wi...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - April 2, 2019 Category: Genetics & Stem Cells Source Type: research

In vitro mammalian cell mutation assays based on the Pig-a gene: A report of the 7th International Workshop on Genotoxicity Testing (IWGT) Workgroup
Publication date: Available online 7 March 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): J.C. Bemis, R.H. HeflichAbstractPig-a gene mutation assays enumerate cells with the glycosylphosphatidylinositol (GPI) anchor-deficient phenotype as a reporter of mutation in the endogenous Pig-a gene. Methods for measuring mutation in this gene are quite well established for in vivo systems. This approach to mutagenicity assessment has now been extended to in vitro mammalian cell-based systems. An expert workgroup from the 7th International Workshop on Genotoxicity Testing tasked with assessi...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - March 31, 2019 Category: Genetics & Stem Cells Source Type: research

Alkaline comet assay results on fresh and one-year frozen whole blood in small volume without cryo-protection in a group of people with different health status
Publication date: Available online 28 March 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Mirta Milić, Ivan Ožvald, Ivana Vinković Vrček, Marijana Vučić Lovrenčić, Višnja Oreščanin, Stefano Bonassi, Emilio Rojas Del CastilloAbstractUsing alkaline comet assay, DNA damage tail length (TL) and tail intensity (TI) parameters were compared between fresh whole blood and 1-year frozen small volume whole blood in EDTA at -80 °C without cryo-preservation. The studied group consisted of 25 volunteers with different health conditions who served as their own controls for frozen ...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - March 29, 2019 Category: Genetics & Stem Cells Source Type: research

Role of aneuploidy in the carcinogenic process: Part III of the Report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases
Publication date: Available online 29 March 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): David Tweats, David Eastmond, Anthony M. Lynch, Azeddine Elhajouji, Roland Froetschl, Micheline Kirsch-Volders, Francesco Marchetti, Kenichi Masumura, Francesca Pacchierotti, Maik SchulerAbstractAneuploidy is regarded as a hallmark of cancer, however, its role is complex with both pro- and anti-carcinogenic effects evident. In this IWGT review, we consider the role of aneuploidy in cancer biology; cancer risk associated with constitutive aneuploidy; rodent carcinogenesis with known chemical a...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - March 29, 2019 Category: Genetics & Stem Cells Source Type: research

The comet assay applied to HepG2 liver spheroids
This study shows that human 3D spheroidal hepatocellular cultures can be successfully applied for genotoxicity testing by the comet assay and represent a promising advanced in vitro model for toxicity testing. (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - March 29, 2019 Category: Genetics & Stem Cells Source Type: research

Chemically induced aneuploidy in germ cells. part ii of the report of the 2017 iwgt workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases
Publication date: Available online 20 March 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Francesca Pacchierotti, Kenichi Masumura, David Eastmond, Azeddine Elhajouji, Roland Froetschl, Micheline Kirsch-Volders, Anthony Lynch, Maik Schuler, David Tweats, Francesco MarchettiAbstractAs part of the 7th International Workshops on Genotoxicity Testing held in Tokyo, Japan in November 2017, a workgroup of experts reviewed and assessed the risk of aneugens for human health. The present manuscript is one of three manuscripts from the workgroup and reports on the unanimous consensus reache...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - March 21, 2019 Category: Genetics & Stem Cells Source Type: research

The genotoxicity of organic extracts from particulate truck emissions produced at various engine operating modes using diesel or biodiesel (B100) fuel: a pilot study
Publication date: Available online 17 March 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Božena Novotná, Jitka Sikorová, Alena Milcová, Martin Pechout, Luboš Dittrich, Michal Vojtíšek-Lom, Pavel Rossner, Táňa Brzicová, Jan TopinkaAbstractAn analysis of the toxic effects of emissions should reflect real traffic conditions. The exhaust emissions of particulate matter from diesel engines strongly depend on their operating conditions, with low-speed, low-load "urban creep" conditions, common for truck traffic in heavily congested urban areas, being one of the worst. We aime...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - March 18, 2019 Category: Genetics & Stem Cells Source Type: research

In vitro cardiotoxicity evaluation of graphene oxide
In conclusion, the nano-GO caused cardiotoxicity in our in vitro model, with mitochondrial disturbances, generation of reactive species and interactions with DNA, indicating the importance of the further evaluation of the safety of nanomaterials. (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - March 15, 2019 Category: Genetics & Stem Cells Source Type: research

Impact of solar UV radiation on amphibians: focus on genotoxic stress
Publication date: Available online 14 March 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): James Eduardo Lago Londero, Maurício Beux dos Santos, André Passaglia SchuchAbstractSolar UV radiation is one of the most important environmental genotoxic factors. Its incidence increased due to stratospheric ozone depletion, climate changes, and deforestation and plays a crucial role in the worldwide decline of the populations of amphibians. Even sublethal effects of UV-induced genotoxicity may cause drastic consequences in the performance and fitness of amphibians. We reviewed the existi...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - March 15, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: April 2019Source: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 840Author(s): (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - March 9, 2019 Category: Genetics & Stem Cells Source Type: research