Mutation Research Genetic Toxicology and Environmental Mutagenesis This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A systematic review of the use of the alkaline comet assay for genotoxicity studies in human colon-derived cells
Publication date: Available online 30 October 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Ezgi Eyluel Bankoglu, Geema Kodandaraman, Helga StopperAbstractThis review describes the use of the comet assay for assessment of DNA damage in human colon cells. We screened 98 papers, which employed human colon -derived cells to analyse DNA damage induced by different insults with the comet assay. In most cases tumour cell lines were used, and only a few studies were performed with primary colon cells. The comet assay was mostly applied to test chemotherapeutics and natural products. We c...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 4, 2018 Category: Genetics & Stem Cells Source Type: research

A systematic review of the use of the comet assay for genotoxicity studies in human colon-derived cells
Publication date: Available online 30 October 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Ezgi Eyluel Bankoglu, Geema Kodandaraman, Helga StopperAbstractThis review describes the use of the comet assay for assessment of DNA damage in human colon cells. We screened 98 papers, which employed human colon -derived cells to analyse DNA damage induced by different insults with the comet assay. In most cases tumour cell lines were used, and only a few studies were performed with primary colon cells. The comet assay was mostly applied to test chemotherapeutics and natural products. We c...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - October 31, 2018 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: December 2018Source: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 836, Part AAuthor(s): (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - October 31, 2018 Category: Genetics & Stem Cells Source Type: research

Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays
Publication date: Available online 29 October 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Roberta A. Mittelstaedt, Vasily N. Dobrovolsky, Javier R. Revollo, Mason G. Pearce, Yiying Wang, Azra Dad, Page B. McKinzie, Hans Rosenfeldt, Berran Yucesoy, Raymond Yeager, Shu-Chieh Hu, Yunan Tang, Seonggi Min, Hyun-Ki Kang, Dong-Jin Yang, Mallikarjuna Basavarajappa, Robert H. HeflichAbstract4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a genotoxic carcinogen found in tobacco and tobacco smoke. Several in vitro and in vivo assays have been used for evaluating the genotoxicity of...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - October 30, 2018 Category: Genetics & Stem Cells Source Type: research

Cytoprotective and genotoxic effects of vitamins K1 and B1 on irinotecan in vitro
Publication date: Available online 26 October 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Eleni Giarma, Zoi Mpampali, Th. Lialiaris, D. MourelatosAbstractCultured human lymphocytes were treated with vitamins K1 and B1, potential anticancer agents, either alone or in combination with irinotecan, a semisynthetic analogue of camptothecin. The frequency of sister chromatid exchanges (SCEs) was measured as an indicator of genotoxicity and the proliferation rate index (PRI) and mitotic index (MI) was measured as indicators of cytostatic effect. Vitamin K1 alone did not induce SCEs at ...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - October 27, 2018 Category: Genetics & Stem Cells Source Type: research