Mutation Research Genetic Toxicology and Environmental Mutagenesis This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Use of in vitro 3D tissue models in genotoxicity testing: strategic fit, validation status and way forward. Report of the working group from the 7th International workshop on genotoxicity testing (IWGT)
Publication date: Available online 15 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Stefan Pfuhler, Jan van Benthem, Rodger Curren, Shareen Doak, Maria Dusinska, Makoto Hayashi, Robert H. Heflich, Darren Kidd, David Kirkland, Yang Luan, Gladys Ouedraogo, Kerstin Reisinger, Toshio Sofuni, Frédérique van Acker, Ying Yang, Raffaella CorviAbstractUse of three-dimensional (3D) tissue equivalents in toxicology has been increasing over the last decade as novel preclinical test systems and as alternatives to animal testing. In the area of genetic toxicology, progress has been ma...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 17, 2020 Category: Genetics & Stem Cells Source Type: research

Oxidative-stress-driven in vivo mutagenesis induced by oral administration of potassium bromate in the small intestines of gpt delta mice
Publication date: Available online 15 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Yasunobu Aoki, Yosuke Taniguchi, Michiyo Matsumoto, Michi Matsumoto, Mizuki Ohno, Kenichi Masumura, Shigeki Sasaki, Teruhisa Tsuzuki, Masayuki Yamamoto, Takehiko NohmiAbstractTumorigenesis induced by oxidative stress are recognized to be based on mutagenesis via indirect mechanism, but mechanism underlying the thresholds shown in the dose responses of oxidative-stress-induced tumorigenesis remains to be elucidated. To reveal this mechanism, we analyzed the dose responses of mutagenesis indu...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 17, 2020 Category: Genetics & Stem Cells Source Type: research

Summary of major conclusions from the 7th International Workshop on Genotoxicity Testing (IWGT), Tokyo, Japan
Publication date: Available online 13 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Hans-Joerg Martus, Roland Froetschl, Bhaskar Gollapudi, Masamitsu Honma, Francesco Marchetti, Stefan Pfuhler, Rita Schoeny, Yoshifumi Uno, Carole Yauk, David J. Kirkland (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 14, 2020 Category: Genetics & Stem Cells Source Type: research

Revisiting the Bacterial Mutagenicity Assays: Report by a Workgroup of the International Workshops on Genotoxicity Testing (IWGT)
Publication date: Available online 13 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Rita Schoeny, Kevin P. Cross, David M. DeMarini, Rosalie Elespuru, Atsushi Hakura, Dan D. Levy, Richard V. Williams, Errol Zeiger, Patricia A. Escobar, Jonathan R. Howe, Masayuki Kato, Jasmin Lott, Martha M. Moore, Stephanie Simon, Leon F. Stankowski, Kei-ichi Sugiyama, Bas-jan M. van der LeedeAbstractThe International Workshop on Genotoxicity Testing (IWGT) meets every four years to obtain consensus on unresolved issues associated with genotoxicity testing. At the 2017 IWGT meeting in Toky...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 14, 2020 Category: Genetics & Stem Cells Source Type: research

Micronuclei and Disease – Report of HUMN Project workshop at Rennes 2019 EEMGS conference
Publication date: Available online 10 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Michael Fenech, Nina Holland, Micheline Kirsch-Volders, Lisbeth E. Knudsen, Karl-Heinz Wagner, Helga Stopper, Siegfried Knasmueller, Claudia Bolognesi, Randa El-Zein, Stefano BonassiAbstractThe “Micronuclei and Disease” workshop was organized by the HUMN Project consortium and hosted by the European Environmental Mutagen and Genomics Society at their annual meeting in Rennes, France, on 23 May 2019. The program of the workshop focused on addressing the emerging evidence linking micronuc...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 11, 2020 Category: Genetics & Stem Cells Source Type: research

Chromosomal aberrations in C-arm fluoroscopy, CT-scan, lithotripsy, and digital radiology staff
Publication date: Available online 7 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Mohsen Shafiee, Sajad Borzoueisileh, Razieh Rashidfar, Maryam Dehghan, Zahra Jaafarian SisakhtAbstractWe have assessed chromosome-type aberrations and micronuclei in the peripheral lymphocytes of personnel working with C-arm fluoroscopy, multi-slice CT-scan, lithotripsy, and digital radiology medical procedures. The study population comprised of 46 exposed workers and 35 controls matched for age, gender, and other confounding factors. Chromosome-type aberrations and micronuclei were analyzed...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - January 9, 2020 Category: Genetics & Stem Cells Source Type: research

Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro
Publication date: Available online 27 December 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Daniel J Smart, Fabian R Helbling, Maëlle Verardo, Alizée Huber, Damian McHugh, Patrick VanscheeuwijckAbstractIn vitro genetic toxicology assays are used to assess the genotoxic potential of chemicals or mixtures. They measure chromosome damage (e.g., micronucleus [MN] formation) or gene mutation, and different combinations of data generated from such assays are evaluated in concert in order to identify genotoxic hazards. Mode-of-action (MoA) information is also fundamental to understand...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 28, 2019 Category: Genetics & Stem Cells Source Type: research

Multiple-endpoint genotoxicity assay for colon carcinogen 1,2-dimethylhydrazine
In this study, we used 1,2-dimethylhydrazine as a model chemical of colon carcinogen to assess gene mutation frequency and chromosomal aberration in vivo simultaneously. Specifically, a gene mutation frequency assay was combined with a multiple-organ micronucleus test (peripheral blood, bone marrow, liver, and colon) in F344 gpt delta transgenic rats. Both gpt mutant frequency and micronucleated cell frequency significantly increased in colon and liver but not in bone marrow. Interestingly, we found that the colon carcinogen induced both gene mutations and micronuclei in the targeted colon tissue. Thus, we demonstrated tha...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 28, 2019 Category: Genetics & Stem Cells Source Type: research

pH-induced variations in the TK1 gene model
Publication date: Available online 28 November 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Julien Massonneau, Chloë Lacombe-Burgoyne, Guylain BoissonneaultAbstractA physiological decrease in extracellular pH (pHe) alters the efficiency of DNA repair and increases formation of DNA double-strand breaks (DSBs). Whether this could translate into genetic instability and variations, was investigated using the TK6 cell model, in which positive selection of the TK1 gene loss-of-function mutations can be achieved from resistance to trifluorothymidine. Cell exposure to suboptimal pH (dow...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 28, 2019 Category: Genetics & Stem Cells Source Type: research

Evaluation of the protective effect on exogenous melatonin in adult rats and their offspring exposed to insecticides methomyl and cypermethrin during pregnancy
Publication date: December 2019Source: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 848Author(s): Ketsia Sabrina do Nascimento Marinho, Clovis José Cavalcanti Lapa Neto, Ilka Dayane Duarte de Sousa Coelho, Meykson Alexandre da Silva, Maria Eduarda Gomes Melo, Katharine Raquel Pereira dos Santos, Cristiano Aparecido Chagas, Álvaro Aguiar Coelho Teixeira, Valéria Wanderley TeixeiraAbstractPregnant women may be exposed to pesticides in an occupational or incidental way, which has been pointed out as a possible cause of problems in the health of newborns. Cypermethrin and methomyl are insectici...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 22, 2019 Category: Genetics & Stem Cells Source Type: research

Serum albumin adducts, DNA adducts and micronuclei frequency measured in benzo[a]pyrene-exposed mice for estimation of genotoxic potency
Publication date: Available online 15 November 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Hitesh V. Motwani, Emelie Westberg, Christian Lindh, Lilianne Abramsson-Zetterberg, Margareta TörnqvistAbstractThe environmental and food contaminant, benzo[a]pyrene {B[a]P, a polycyclic aromatic hydrocarbon (PAH)}, is classified as a human carcinogen by the International Agency for Research on Cancer. The carcinogenicity of B[a]P is linked to the formation of electrophilic metabolites, namely B[a]P-diol epoxides (BPDEs) occurring as stereoisomers. In this work, we quantified the metaboli...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 15, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: December 2019Source: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 848Author(s): (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 9, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: November 2019Source: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 847Author(s): (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 4, 2019 Category: Genetics & Stem Cells Source Type: research

A special issue dedicated to Dr. Bruce N. Ames: Introduction
Publication date: Available online 2 November 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Graham Walker (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - November 4, 2019 Category: Genetics & Stem Cells Source Type: research

Pig-a mutations in bone marrow erythroblasts of rats treated with 7,12-dimethyl-benz[a]anthracene
Publication date: Available online 19 October 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Javier R. Revollo, Azra Dad, Mason G. Pearce, Roberta A. Mittelstaedt, Timothy W. Robison, Vasily N. DobrovolskyAbstractFlow cytometry-based phenotypic detection of red blood cells (RBCs) deficient in surface markers anchored by glycosylphosphatidylinositol (GPI) is an efficient tool for monitoring somatic mutation in mammalian species. Biochemical considerations suggest that GPI-anchored marker-deficient RBCs found in peripheral blood are due to mutations in the endogenous X-linked phospha...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - October 20, 2019 Category: Genetics & Stem Cells Source Type: research