The mutagenic activity of select azo compounds in MutaMouse target tissues in vivo and primary hepatocytes in vitro
Publication date: Available online 13 June 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Julie A. Cox, Paul A. WhiteAbstractThe mutagenicity of Direct Black 38, Sudan I, and Para Red were evaluated in the in vivo MutaMouse assay and the in vitro MutaMouse primary hepatocyte (PH) assay. Direct Black 38 is an International Agency for Research on Cancer (IARC) Group 1 carcinogen and a prototypical benzidine-based azo compound that requires azo-reduction to yield a DNA-reactive metabolite. Sudan I and Para Red are structurally related azo compounds that have been detected as illegal c...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - June 14, 2019 Category: Genetics & Stem Cells Source Type: research

Corrigendum to “Simulation of mouse and rat spermatogenesis to inform genotoxicity testing using OECD test guideline 488” [Mutat. Res. 832–833 (2018) 19–28]
Publication date: Available online 12 June 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Francesco Marchetti, Marilyn J. Aardema, Carol Beevers, Jan van Benthem, George R. Douglas, Roger Godschalk, Carole L. Yauk, Robert Young, Andrew Williams (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - June 13, 2019 Category: Genetics & Stem Cells Source Type: research

Introduction for human biomonitoring special issue
Publication date: Available online 8 June 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Andrew Collins, Mirta Milic, Stefano Bonassi, Maria Dusinska (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - June 10, 2019 Category: Genetics & Stem Cells Source Type: research

The IWGT in vitro Mammalian Cell Gene Mutation (MCGM) assays working group—Introductory remarks & consensus statements
Publication date: Available online 31 May 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): B. Bhaskar Gollapudi, Paul A. White, Masamitsu HonmaAbstractAssays for gene mutations in cultured mammalian cells, i.e., Mammalian Cell Gene Mutation (MCGM) assays, are widely used in genetic toxicology laboratories worldwide; over the past four decades they have been commonly employed in safety assessment studies, and studies designed to address hypothesis-driven research questions. Despite many advances in the fields of cellular and molecular biology over the past four decades, the MCGM assay...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - June 7, 2019 Category: Genetics & Stem Cells Source Type: research

Corrigendum to “Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell Gene mutation assays) and integration with somatic cell testing.” [Mutat. Res. 832–833 (2018) 7–18]
Publication date: Available online 7 June 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Francesco Marchetti, Marilyn J. Aardema, Carol Beevers, Jan van Benthem, Roger Godschalk, Andrew Williams, Carole L. Yauk, Robert Young, George R. Douglas (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - June 7, 2019 Category: Genetics & Stem Cells Source Type: research

Reference cells in the comet assay
Publication date: Available online 5 June 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Gunnar Brunborg (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - June 6, 2019 Category: Genetics & Stem Cells Source Type: research

Ganoderma Lucidum induces oxidative DNA damage and enhances the effect of 5-Fluorouracil in colorectal cancer in vitro and in vivo
Publication date: Available online 3 June 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Alena Opattova, Josef Horak, Sona Vodenkova, Klara Kostovcikova, Andrea Cumova, Peter Macinga, Natalie Galanova, Alexandra Rejhova, Ludmila Vodickova, Katarina Kozics, Karolina Turnovcova, Tomas Hucl, Daniel Sliva, Pavel VodickaAbstractThe first-line chemotherapy of colorectal cancer (CRC), besides surgery, comprises administration of 5-Fluorouracil (5FU). Apart from cytotoxic effect on cancer cells, 5FU may also cause adverse side effects. Ganoderma Lucidum (GLC) is a mushroom used in Traditio...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - June 4, 2019 Category: Genetics & Stem Cells Source Type: research

Mutagenicity Emission Factors of Canola Oil and Waste Vegetable Oil Biodiesel: Comparison to Soy Biodiesel
Publication date: Available online 31 May 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): David M. DeMarini, Esra Mutlu, Sarah H. Warren, Charly King, M. Ian Gilmour, William P. LinakAbstractCanola (or rapeseed) oil and waste vegetable oil (WVO) are used commonly to make biodiesel fuels composed completely from these oils (B100) or as blends with petroleum diesel (B0). However, no studies have reported the mutagenic potencies of the particulate matter with diameter ≤2.5 µm (PM2.5) or the mutagenicity emission factors, such as revertants/MJthermal (rev/MJth) for these biodiesel ...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - June 1, 2019 Category: Genetics & Stem Cells Source Type: research

The IWGT In Vitro Mammalian Cell Gene Mutation (MCGM) Assays Working Group – Introductory Remarks & Consensus Statements
Publication date: Available online 31 May 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): B. Bhaskar Gollapudi, Paul A. White, Masamitsu HonmaAbstractAssays for gene mutations in cultured mammalian cells, i.e., Mammalian Cell Gene Mutation (MCGM) assays, are widely used in genetic toxicology laboratories worldwide; over the past four decades they have been commonly employed in safety assessment studies, and studies designed to address hypothesis-driven research questions. Despite many advances in the fields of cellular and molecular biology over the past four decades, the MCGM assay...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - June 1, 2019 Category: Genetics & Stem Cells Source Type: research

Silica coated iron oxide nanoparticles-induced cytotoxicity, genotoxicity and its underlying mechanism in human HK-2 renal proximal tubule epithelial cells
In conclusion, these findings provide new insights into the cytotoxicity of silica coated IONPs that may support their further safer use. (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - May 31, 2019 Category: Genetics & Stem Cells Source Type: research

Genotoxic effects of intermediate frequency magnetic fields on blood leukocytes in vitro
Publication date: Available online 30 May 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Annamária Brech, Györgyi Kubinyi, Zsuzsanna Németh, József Bakos, Serena Fiocchi, György ThuróczyAbstractThe widespread presence of electromagnetic sources in daily life has initiated several studies on the effects of radiofrequency and power frequency fields. Only few investigations on the genotoxic effects of exposure to intermediate frequency magnetic fields (IF-MF) have been done so far. Therefore, the aim of this study was to evaluate possible genotoxic effects of exposure to 123.90...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - May 31, 2019 Category: Genetics & Stem Cells Source Type: research

Determination of genotoxic effects in hemodialysis patients with chronic kidney disease and the role of diabetes mellitus and other biochemical parameters
Publication date: Available online 30 May 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Sevcan Mamur, Deniz Yuzbasioglu, Kadriye Altok, Fatma Unal, Serpil Muge DegerAbstractChronic kidney disease (CKD) is a common health problem. The primary etiology of CKD is diabetes mellitus (DM). The aim of our study is to determine the possible role of DM and also effects of other factors such as hypertension, duration of hemodialysis (HD), age, sex, body mass index (BMI), and levels of hemoglobin (HB), intact parathormone (iPTH), and ferritin on genetic alterations in maintenance HD patients...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - May 31, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: May 2019Source: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 841Author(s): (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - May 26, 2019 Category: Genetics & Stem Cells Source Type: research

Ecotoxicology: conventional and new topics and methods
Publication date: Available online 25 May 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Miroslav Misik, Marina Isidori, Gisela Umbuzeiro (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - May 26, 2019 Category: Genetics & Stem Cells Source Type: research

DNA damage and gene expression changes in patients exposed to low-dose X-radiation during neuro-interventional radiology procedures
Publication date: Available online 21 May 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Shangamithra Visweswaran, Santhosh Joseph, Vinay Hegde S, Annalakshmi O, M.T Jose, Venkatachalam PerumalAbstractInterventional radiology-based imaging is the preferred choice for diagnosis and therapy of many complex diseases, despite possible adverse effects of the radiation exposures. We have measured induced DNA damage and changes in gene expression in relation to entrance surface dose (ESD) in peripheral blood samples of patients (n = 51) who underwent neuro-interventional radiological ...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - May 22, 2019 Category: Genetics & Stem Cells Source Type: research