Mutation Research Genetic Toxicology and Environmental Mutagenesis This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Evaluation of the DNA damage in lymphocytes, sperm and buccal cells of workers under environmental and occupational boron exposure conditions
This study was conducted in two districts of Balıkesir; Bandırma and Bigadic, which geographically belong to the Marmara Region of Turkey. Bandırma is the production and exportation zone for the produced boric acid and some borates and Bigadic has the largest B deposits in Turkey. 102 male workers who were occupationally exposed to boron from Bandırma and 110 workers who were occupationally and environmentally exposed to boron from Bigadic participated to our study. In this study the DNA damage in the sperm, blood and buccal cells of 212 males was evaluated by comet and micronucleus assays. No significant increase in t...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 24, 2018 Category: Genetics & Stem Cells Source Type: research

Assessment of DNA damage in Polish children environmentally exposed to pesticides
In conclusion, despite just environmental pesticide exposure in the test group of children, significant biological effects were detected. (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 22, 2018 Category: Genetics & Stem Cells Source Type: research

Dry olive leaf extract attenuates DNA damage induced by estradiol and diethylstilbestrol in human peripheral blood cells in vitro
Publication date: Available online 21 December 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Dijana Topalović, Dragana Dekanski, Biljana Spremo-Potparević, Andrea Pirković, Sunčica Borozan, Vladan Bajić, Danilo Stojanović, Francesca Giampieri, Massimiliano Gasparrini, Lada ŽivkovićAbstractPhenolic groups of steroidal or nonsteroidal estrogens can redox cycle, leading to oxidative stress, where creation of reactive oxygen species are recognized as the main mechanism of their DNA damage properties. Dry olive (Olea europaea L.) leaf extract is known to contain bioactive and a...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 22, 2018 Category: Genetics & Stem Cells Source Type: research

18F-FDG PET/CT scanning: biological effects on patients: entrance surface dose,: DNA damage, and chromosome aberrations in lymphocytes
Publication date: Available online 19 December 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Akshaya Prasad, Shangamithra Visweswaran, Karthik Kanagaraj, Venkateswarlu Raavi, M Arunan, E Venkatachalapathy, S Paneerselvam, MT Jose, Annalakshmi Ozhimuthu, Venkatachalam PerumalAbstractPositron Emission Tomography/Computed Tomography (PET/CT), a combination of PET and CT, is used in tumor staging, therapy planning, and treatment response monitoring. During PET imaging, patients receive low doses of radiation, which can induce an adaptive response and necessitate higher doses for thera...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 20, 2018 Category: Genetics & Stem Cells Source Type: research

Manganese oxide nanoparticles induce genotoxicity and DNA hypomethylation in the moss Physcomitrella patens
Publication date: Available online 18 December 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Ilika Ghosh, Abhishek Sadhu, Yuji Moriyasu, Maumita Bandyopadhyay, Anita MukherjeeGraphical abstract (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 19, 2018 Category: Genetics & Stem Cells Source Type: research

Buccal epithelial cell micronuclei: sensitive, non-invasive biomarkers of occupational exposure to low doses of ionizing radiation
Publication date: Available online 19 December 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Laura Aguiar Torres, Armindo dos Santos Rodrigues, Diana Linhares, Ricardo Camarinho, Zélia Maria Nunes Páscoa Soares Rego, Patrícia Ventura GarciaAbstractWe have evaluated buccal epithelial cell micronucleus formation as a biomarker of genotoxic damage following occupational exposure to low doses of ionizing radiation. Buccal epithelial cells were collected from 42 occupationally exposed medical personnel and 39 non-exposed individuals (reference group). Each individual in the exposed ...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 19, 2018 Category: Genetics & Stem Cells Source Type: research

Micronuclei frequency in peripheral blood lymphocytes and levels of anti-p53 autoantibodies in serum of residents of Kowary city regions (Poland) with elevated indoor concentrations of radon
ConclusionThe problem of the radon exposure is still unresolved and needs further studies on bigger human cohorts in order to search for more sensitive biomarkers. (Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis)
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 16, 2018 Category: Genetics & Stem Cells Source Type: research

Lactobacillus plantarum MON03 Counteracts Zearalenone Génotoxicty in Mice; chromosome aberrations, Micronuclei, DNA fragmentation and Apoptotique gene expression
This study was conducted to evaluate the ability of lactic acid bacteria, isolated from Tunisia traditional butter, Lactobacillus plantarum MON03 (LP) to protect mice against cytotoxicity and genotoxicity induced by ZEN. Two doses of LP (2 × 109 CFU/L, ~ 2 mg/kg and 4 × 109 CFU/L, ~ 4 mg/kg) was added alone or in combination with a toxic intragastric ZEN (40 mg/kg representing 8% of LD50) dose daily for 2 wk by oral gavage. The control group received distilled water. The positive control groups received Colchicin (4 mg/kg bw) for the micronucleus assay and mitomycin C (1 mg/kg bw) for the chromosome abe...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 16, 2018 Category: Genetics & Stem Cells Source Type: research

Ambient fine particulate matter (PM2.5) induces oxidative stress and pro-inflammatory response via up-regulating the expression of CYP1A1/1B1 in human bronchial epithelial cells in vitro
Publication date: Available online 12 December 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Qi Yuan, Yaoyao Chen, Xiaobo Li, Haiyan Chu, Zhengdong ZhangAbstractWe investigated the mechanism responsible for the oxidative stress and pro-inflammatory response triggered by PM2.5 collected from Nanjing of China. Two human bronchial epithelia cell lines (HBE and BEAS-2B) were used. Human gene expression profile microarray was performed to investigate the alteration of gene expression in PM2.5-treated HBE cells. The results of ROS assay and ELISA indicated that PM2.5 (150 µg/ml) incr...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 13, 2018 Category: Genetics & Stem Cells Source Type: research

Early prediction of liver carcinogenicity due to occupational exposure to pesticides
This study aimed to estimate novel biomarkers for early prediction of liver malignancy due to occupational exposure to pesticides in two groups of workers with different socioeconomic standard (highly educated urban researchers and low educated rural pesticides sprayers). This study included 50 urban researchers and 50 rural pesticides sprayers occupationally exposed to pesticides. They were compared with 50 non-exposed urban researchers and 50 non-exposed rural subjects. Several tumor biomarkers were estimated; P53 protein, Alfa fetoprotein (AFP), and Alpha-L-fucosidase (AFU). Additionally, telomerase enzyme activity, Rel...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 12, 2018 Category: Genetics & Stem Cells Source Type: research

Optimization of the harvesting and freezing conditions of human cell lines for DNA damage analysis by the alkaline Comet assay
This study was conducted in glial A172 and lung alveolar epithelial A549 cells. Two cell detachment methods (mechanical vs enzymatic) and two cryoprotective media [FBS + 10% DMSO vs Cell Culture Media (CCM) + 10% DMSO] were tested, and DNA damage assessed at four time points following storage at - 80 °C (one, two, four and eight weeks). In both cell lines, no differences in % tail intensity were detected between fresh and frozen cells up to eight weeks, irrespective of the harvesting method and freezing medium used. However, freshly isolated A172 cells exhibited a significant lower DNA damage when resuspended in CCM...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 11, 2018 Category: Genetics & Stem Cells Source Type: research

Use of human derived liver cells for the detection of genotoxins in comet assays
Publication date: Available online 10 December 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Miroslav Mišík, Armen Nersesyan, Nathalie Ropek, Wolfgang W Huber, Elisabeth Haslinger, Siegfried KnasmuellerAbstractOne of the problems of in vitro genotoxicity testing is the inadequate representation of drug metabolizing enzymes in indicator cells which are currently used. An alternative is the use of human derived liver cells lines which retained the activities of enzymes that catalyze the activation and detoxification of genotoxins. Several cell lines were identified which were used...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 11, 2018 Category: Genetics & Stem Cells Source Type: research

Nephrotoxicity: topical issue
Publication date: Available online 6 December 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Alena Gabelova, Katarina Kozics, Lucyna Kapka-Skrzypczak, Marcin Kruszewski, Monika SramkovaAbstractDrug-induced kidney injury is one of the most significant adverse events and dose limiting factor in chemotherapy as well a major cause of prospective drug attrition during pharmaceutical development. Moreover, kidney injury can also occur as a consequence of exposures to environmental xenobiotics such as heavy metals, fungal toxins and nanomaterials. The lack of adequate in vitro human kidne...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 7, 2018 Category: Genetics & Stem Cells Source Type: research

Effect of inter-individual variability in human liver cytochrome P450 isozymes on cyclophosphamide-induced micronucleus formation
Publication date: Available online 5 December 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Yuki Kishino, Tomoko Hasegawa, Ayako Kato, Yumi Nishiya, Veronika Rozhnal, Kyoko Watanabe, Wataru Takasaki, Takashi Yamoto, Kazuhiko MoriAbstractWe investigated the relationship between metabolic activities of cytochrome P450 (CYP) isozymes present in microsomal fractions derived from the livers of 78 donors and micronucleus induction by cyclophosphamide (CPA). Consequently, a wide inter-individual variation in CYP activities was observed among the 78 donors. The CYP activities were partial...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 6, 2018 Category: Genetics & Stem Cells Source Type: research

“Risk is in the air”: Polycyclic aromatic hydrocarbons, metals and mutagenicity of atmospheric particulate matter in a town of Northern Italy (Respira study)
Publication date: Available online 16 November 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Donatella Feretti, Roberta Pedrazzani, Elisabetta Ceretti, Mario Dal Grande, Ilaria Zerbini, Gaia Claudia Viviana Viola, Umberto Gelatti, Francesco Donato, Claudia ZaniAbstractAir pollution has well-known harmful effects on human beings, causing both acute and chronic diseases. Some data suggest that genetic damage occurring early in life may influence the risk of having cancer and other chronic diseases in adulthood. Therefore, there is a growing interest in studying the genotoxic activit...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - December 5, 2018 Category: Genetics & Stem Cells Source Type: research