Integration of Micronucleus, Comet, and Pig-a Gene Mutation Endpoints into Rat 15-day Repeat-treatment Studies: Proof-of-principle with Auramine O

In conclusion, using a multiple-endpoint genotoxicity assay method can reduce the number of experimental animals, boost the efficiency of the experiment, and improve the accuracy of investigations of genotoxicity.
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research