Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Assessment of mutagenicity of water from Lake Sevan, Armenia with application of Tradescantia (clone 02)
Publication date: August 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Volumes 800–802 Author(s): R.E. Avalyan, E.A. Aghajanyan, A. Khosrovyan, A.L. Atoyants, A.E. Simonyan, R.M. Aroutiounian For many decades water resources in Armenia have been affected by anthropogenic activity, therefore, a regular bioindication of genotoxic effects of the water bodies is desirable. The genotoxicity of water samples collected from different parts of Lake Sevan were assessed by means of Trad-SHM (stamen hair mutation) assay using Tradescantia (clone 02). Here we report a significant increase...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - April 21, 2017 Category: Cytology Source Type: research

Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease
Publication date: Available online 6 April 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Zachary D. Nagel, Bevin P. Engelward, David J. Brenner, Thomas J. Begley, Robert W. Sobol, Jason H. Bielas, Peter J. Stambrook, Qingyi Wei, Jennifer J. Hu, Mary Beth Terry, Caroline Dilworth, Kimberly A. McAllister, Les Reinlib, Leroy Worth, Daniel T. Shaughnessy The rise of advanced technologies for characterizing human populations at the molecular level, from sequence to function, is shifting disease prevention paradigms toward personalized strategies. Because minimizati...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - April 11, 2017 Category: Cytology Source Type: research

Torsional stress promotes trinucleotidic expansion in spermatids
Publication date: Available online 9 April 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Olivier Simard, Seyedeh Raheleh Niavarani, Virginie Gaudreault, Guylain Boissonneault Trinucleotide repeats are involved in various neurodegenerative diseases and are highly unstable both in dividing or non-dividing cells. In Huntington disease (HD), the age of onset of symptoms is inversely correlated to the number of CAG repeats within exon 1 of the HTT gene. HD shows paternal anticipation as CAG repeats are increased during spermatogenesis. CAG expansion were indeed found to be ge...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - April 11, 2017 Category: Cytology Source Type: research

Biotesting of water of Lake Sevan with Tradescantia (clone 02)
Publication date: Available online 31 March 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): R.E. Avalyan, E.A. Aghajanyan, A. Khosrovyan, A.L. Atoyants, A.E. Simonyan, R.M. Aroutiounian For many decades water resources in Armenia have been affected by anthropogenic activity, consequently, a regular bioindication of genotoxic effects of the water bodies is desirable. The genotoxicity of water samples collected from different parts of Lake Sevan were assessed by means of Trad-SHM (stamen hair mutation) assay using Tradescantia (clone 02). Here we report a significant incre...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - April 1, 2017 Category: Cytology Source Type: research

The Legacy of William Morgan: The PNNL Years
Publication date: Available online 18 March 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Antone L. Brooks (Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis)
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - March 18, 2017 Category: Cytology Source Type: research

Ongoing evolution of Pseudomonas aeruginosa PAO1 sublines complicates studies of DNA damage repair and tolerance
Publication date: Available online 16 March 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Julia Sidorenko, Tatjana Jatsenko, Maia Kivisaar Sublines of the major P. aeruginosa reference strain PAO1 are derivatives of the original PAO1 isolate, which are maintained in laboratories worldwide. These sublines display substantial genomic and phenotypic variation due to ongoing microevolution. Here, we examined four sublines, MPAO1, PAO1-L, PAO1-DSM and PAO1-UT, originated from different laboratories, and six DNA polymerase-deficient mutants from the P. aeruginosa MPAO1 transpos...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - March 16, 2017 Category: Cytology Source Type: research

Transmission of persistent ionizing radiation-induced foci through cell division in human primary cells
This study evaluates the frequency and kinetics of persistent IRIF and analyzes their impact on cell proliferation. We observed persistent IRIF up to 7 days postirradiation, and more than 70% of cells exposed to 5Gy had at least one of these persistent IRIF 24hours after exposure. Moreover we demonstrated that persistent IRIF did not block cell proliferation definitively. The frequency of IRIF was lower in daughter cells, due to asymmetric distribution of IRIF between some of them. We report a positive association between the presence of IRIF and the likelihood of DNA missegregation. Hence, the structure formed after the p...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - March 9, 2017 Category: Cytology Source Type: research

International organizations, risk assessment and research –why, what and how
Publication date: Available online 8 March 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): R. Julian Preston The process of setting radiation protection standards requires the interaction of a number of international and national organizations that in turn require the input of scientific and regulatory experts. Bill Morgan served in an expert capacity for several of these organizations particularly for the application of radiation biology data to risk assessment. He brought great enthusiasm and dedication to these committee efforts. In fact, he really enjoyed this type of ser...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - March 8, 2017 Category: Cytology Source Type: research

Mitochondrial DNA damage and oxidative damage in HL-60 cells exposed to 900MHz radiofrequency fields
Publication date: Available online 7 March 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Yulong Sun, Lin Zong, Zhen Gao, Shunxing Zhu, Jian Tong, Yi Cao HL-60 cells, derived from human promyelocytic leukemia, were exposed to continuous wave 900MHz radiofrequency fields (RF) at 120μW/cm2 power intensity for 4hours/day for 5 consecutive days to examine whether such exposure is capable damaging the mitochondrial DNA (mtDNA) mediated through the production of reactive oxygen species (ROS). In addition, the effect of RF exposure was examined on 8-hydroxy-2’-dexoyguanosin...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - March 7, 2017 Category: Cytology Source Type: research

Targeted Cytoplasmic Irradiation and Autophagy
Publication date: Available online 1 March 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Jinhua Wu, Bo Zhang, Yen-Ruh Wuu, Mercy M. Davidson, Tom K. Hei The effect of ionizing irradiation on cytoplasmic organelles is often underestimated because the general dogma considers direct DNA damage in the nuclei to be the primary cause of radiation induced toxicity. Using a precision microbeam irradiator, we examined the changes in mitochondrial dynamics and functions triggered by targeted cytoplasmic irradiation with α-particles. Mitochondrial dysfunction induced by targeted ...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - March 1, 2017 Category: Cytology Source Type: research

Analysis of Microsatellite Instability in CRISPR/Cas9 Editing Mice
Publication date: Available online 28 February 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Xueyun Huo, Yating Du, Jing Lu, Meng Guo, Zhenkun Li, Shuangyue Zhang, Xiaohong Li, Zhenwen Chen, Xiaoyan Du Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR- associated (Cas) protein 9 system is a novel and powerful tool which is widely used for genome editing. CRISPR/Cas9 is RNA-guided and can lead to desired genomic modifications. However, whether the CRISPR/Cas9-mediated genome editing causes genomic alterations and genomic instability, such as m...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - February 28, 2017 Category: Cytology Source Type: research

Effect of modeled microgravity on radiation-induced adaptive response of root growth in Arabidopsis thaliana
Publication date: February 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Volume 796 Author(s): Chenguang Deng, Ting Wang, Jingjing Wu, Wei Xu, Huasheng Li, Min Liu, Lijun Wu, Jinying Lu, Po Bian Space particles have an inevitable impact on organisms during space missions; radio-adaptive response (RAR) is a critical radiation effect due to both low-dose background and sudden high-dose radiation exposure during solar storms. Although it is relevant to consider RAR within the context of microgravity, another major space environmental factor, there is no existing evidence as to i...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - February 27, 2017 Category: Cytology Source Type: research

Induction of the Long Noncoding RNA NBR2 from the Bidirectional BRCA1 Promoter Under Hypoxic Conditions
Publication date: Available online 16 February 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): J. Erin Wiedmeier, Anna Ohlrich, Adrian Chu, Michael R. Rountree, Mitchell S. Turker BRCA1 plays an important role in preventing breast cancer and is often silenced or repressed in sporadic cancer. The BRCA1 promoter is bidirectional: it drives transcription of the long non-coding (lnc) NBR2 transcript in the opposite orientation relative to the BRCA1 transcript. Hypoxic conditions repress BRCA1 transcription, but their effect on expression of the NBR2 transcript has not been re...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - February 15, 2017 Category: Cytology Source Type: research

Modulation of Modeled Microgravity on Radiation-Induced Adaptive Response of Root Growth in Arabidopsis thaliana
Publication date: Available online 14 February 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Chenguang Deng, Ting Wang, Jingjing Wu, Wei Xu, Huasheng Li, Min Liu, Lijun Wu, Jinying Lu, Po Bian Space particles have an inevitable impact on organisms during space missions; radio-adaptive response (RAR) is a critical radiation effect due to both low-dose background and sudden high-dose radiation exposure during solar storms. Although it is relevant to consider RAR within the context of microgravity, another major space environmental factor, to our knowledge, there is no...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - February 13, 2017 Category: Cytology Source Type: research

Cyto-genotoxic and DNA methylation changes induced by different crystal phases of TiO2-np in bronchial epithelial (16-HBE) cells
Publication date: Available online 10 February 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Manosij Ghosh, Deniz Oner, Radu-Corneliu Duca, Stevan Cokic, Sven Seys, Stef Kerkhofs, Kirsten Van Landuyt, Peter Hoet, Lode Godderis With the increase in use of TiO2-np, a better understanding of their safety is important. In the present study the effect of different crystal phases of TiO2-np (anatase, rutile and anatase: rutile mixture; 20–26nm) were studied for cyto-genotoxicity and global DNA methylation and hydroxymethylation. Cytotoxic response was observed at a conc...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - February 10, 2017 Category: Cytology Source Type: research