Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A change in structural integrity of c-Kit mutant D816V causes constitutive signaling
Publication date: Available online 17 February 2018 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Pawan Kumar Raghav, Ajay Kumar Singh, Gurudutta Gangenahalli Several signaling pathways, ligands, and genes that regulate proliferative and self-renewal properties of the Hematopoietic Stem Cells (HSCs) have been studied meticulously. One of the signaling pathways that play a crucial role in the process of hematopoiesis is the Stem Cell Factor (SCF) mediated c-Kit pathway. The c-Kit is a Receptor Tyrosine Kinase (RTK), which is expressed in the cells including HSCs. It undergoes d...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - February 17, 2018 Category: Cytology Source Type: research

Replication stress in mitochondria
We describe here major challenges for human mtDNA replication, the mechanistic aspects of the process that are to a large extent original, and their consequences on disease. (Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis)
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - February 2, 2018 Category: Cytology Source Type: research

The roles of human MTH1, MTH2 and MTH3 proteins in maintaining genome stability under oxidative stress
Publication date: Available online 31 January 2018 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Kazunari Hashiguchi, Michio Hayashi, Mutsuo Sekiguchi, Keiko Umezu The hydrolysis of nucleotides containing 8-oxo-7,8-dihydroguanine (8-oxoG) is important in the maintenance of genome stability. Human cells possess three types of proteins, MTH1 (NUDT1), MTH2 (NUDT15) and MTH3 (NUDT18), which have the potential to hydrolyze deoxyribonucleoside di- and triphosphates containing 8-oxoG to the monophosphate, the form of which is unusable for DNA synthesis. To elucidate the physiologica...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - February 1, 2018 Category: Cytology Source Type: research

Quantification of DNA damage products by gas chromatography tandem mass spectrometry in lung cell lines and prevention effect of thyme antioxidants on oxidative induced DNA damage
Publication date: March 2018 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Volume 808 Author(s): Önder Aybastıer, Sam Dawbaa, Cevdet Demir, Oğuzhan Akgün, Engin Ulukaya, Ferda Arı Lung cancer has a high treatment cost and poor prognosis in comparison to other types of cancers. This work was involved in studying oxidative DNA base damage inhibition. Accordingly, standard carvacrol, thymol, thymoquinone with water and water-methanol extract of thyme (Origanum vulgare L. subsp. hirtum (link.) Ietswaart), thyme oil and thyme water were prepared and investigated for their efficacy to...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - January 21, 2018 Category: Cytology Source Type: research

Special Section: Replication Stress, a threat to the nuclear and mitochondrial genome
Publication date: Available online 5 January 2018 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Lisa Wiesmüller, Karin Scharffetter-Kochanek, Hartmut Geiger (Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis)
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - January 5, 2018 Category: Cytology Source Type: research

Trimethoprim-sulfamethoxazole treatment increases the Pig-a mutant frequency in peripheral blood from severely malnourished rats
Publication date: Available online 30 December 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): M. Monserrat Pacheco-Martínez, Elsa Cervantes-Ríos, María del Carmen García-Rodríguez, Rocío Ortiz-Muñiz Severe malnutrition is a complex condition that increases susceptibility to infections. Thus, drugs are extensively used in malnutrition cases. In the present study, we assessed the mutagenic effects of combined trimethoprim and sulfamethoxazole (TMP-SMX) treatment in undernourished (UN) and well-nourished (WN) rats. Six-week-old UN and WN Han-Wistar rats were treated w...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - December 30, 2017 Category: Cytology Source Type: research

Strategies for identification of mutations induced by carbon-ion beam irradiation in Arabidopsis thaliana by whole genome re-sequencing
Publication date: Available online 9 December 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Yan Du, Shanwei Luo, Lixia Yu, Tao Cui, Xia Chen, Jiangyan Yang, Xin Li, Wenjian Li, Jufang Wang, Libin Zhou Heavy-ion beam irradiation is a powerful physical mutagen that has been used to create numerous mutant materials in plants. These materials are an essential resource for functional genomics research in the post-genome era. The advent of next-generation sequencing (NGS) technology has promoted the study of functional genomics and molecular breeding. A wealth of informa...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - December 10, 2017 Category: Cytology Source Type: research

Association of H3K79 monomethylation (an epigenetic signature) with arsenic-induced skin lesions
The objective of the study was to analyze the post-translational modifications of the major histone H3 and the associated molecular crosstalk to identify the epigenetic signature of arsenic susceptibility. Herein, we identified significant upregulation of H3K79me1, in individuals with arsenic-induced skin lesion (WSL), and H3K79me1 was found to be regulated by the upstream methyltransferase DOT1L. Moreover, the downstream target molecule 53BP1, a tumor suppressor protein that has a docking preference for H3K79me1 at a site of a double-strand break (DSB), was downregulated, indicating greater DNA damage in the WSL group. We...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - November 15, 2017 Category: Cytology Source Type: research

Molecular criteria for mutagenesis by DNA methylation: some computational elucidations
Publication date: Available online 10 November 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Tejeshwori Salam, S. Premila Devi, R.H. Duncan Lyngdoh Alkylating agents and N-nitroso compounds are well-known mutagens and carcinogens which act by alkylating DNA at the nucleobase moieties. Criteria for mutagenicity through DNA alkylation include (a) absence of the Watson-Crick (N1-guanine and N3-thymine) protons, (b) rotation of the alkyl group away from the H-bonding zone, (c) configuration of the alkylated base pair close to the Watson-Crick type. This computational study br...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - November 10, 2017 Category: Cytology Source Type: research

Biological effects of carbon ion beams with various LETs on budding yeast Saccharomyces cerevisiae
Publication date: Available online 7 November 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Youichirou Matuo, Yoshinobu Izumi, Yoshiya Furusawa, Kikuo Shimizu It has been established that irradiation with higher linear energy transfer (LET) increases lethality and mutagenicity more than that with lower LET. However, the characteristics specific to carbon ion beam have not yet been elucidated. Yeast cells were irradiated with carbon ions with an LET of 13 or 50 keV/μm, and cell survival and mutation frequency were analyzed. The results, combined with our previous finding...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - November 7, 2017 Category: Cytology Source Type: research

DNA replication stress drives fragile site instability
Publication date: Available online 18 October 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Michal Irony-Tur Sinai, Batsheva Kerem DNA replication stress is one of the early drivers enabling the ongoing acquisition of genetic changes arising during tumorigenesis. As such, it is a feature of most pre-malignant and malignant cells. In this review article, we focus on the early events initiating DNA replication stress and the preferential sensitivity of common fragile sites (CFSs) to this stress. CFSs are specific genomic regions within the normal chromosomal structure, which...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - October 19, 2017 Category: Cytology Source Type: research

Replication stress in hematopoietic stem cells in mouse and man
Publication date: Available online 18 October 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Johanna Flach, Michael Milyavsky Life-long blood regeneration relies on a rare population of self-renewing hematopoietic stem cells (HSCs). These cells’ nearly unlimited self-renewal potential and lifetime persistence in the body signifies the need for tight control of their genome integrity. Their quiescent state, tightly linked with low metabolic activity, is one of the main strategies employed by HSCs to preserve an intact genome. On the other hand, HSCs need to be able to quic...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - October 19, 2017 Category: Cytology Source Type: research

Efficient repair of DNA double strand breaks in individuals from high level natural radiation areas of Kerala coast, south-west India
In conclusion, lower induction and efficient repair of DNA DSBs in HLNRA groups is suggestive of an in vivo radio-adaptive response due to priming effect of chronic low dose radiation prevailing in this area. (Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis)
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - September 20, 2017 Category: Cytology Source Type: research

Corrigendum to “Estimation of the minimum mRNA splicing error rate in vertebrates” [Mutat Res. 2016;784:34-38]
Publication date: August 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Volumes 800–802 Author(s): A. Skandalis (Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis)
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - September 19, 2017 Category: Cytology Source Type: research

Beyond interstrand crosslinks repair: contribution of FANCD2 and other Fanconi Anemia proteins to the replication of DNA
Publication date: Available online 14 September 2017 Source:Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Author(s): Maria B. Federico, Paola Campodónico, Natalia S. Paviolo, Vanesa Gottifredi Biallelic mutations of FANCD2 and other components of the Fanconi Anemia (FA) pathway cause a disease characterized by bone marrow failure, cancer predisposition and a striking sensitivity to agents that induce crosslinks between the two complementary DNA strands (inter-strand crosslinks-ICL). Such genotoxins were used to characterize the contribution of the FA pathway to the genomic stability of cells,...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - September 15, 2017 Category: Cytology Source Type: research