Iron in infection and immunity
Publication date: Available online 24 May 2020Source: Molecular Aspects of MedicineAuthor(s): Manfred Nairz, Günter Weiss (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - May 26, 2020 Category: Molecular Biology Source Type: research
Intravenous iron supplementation therapy
Publication date: Available online 19 May 2020Source: Molecular Aspects of MedicineAuthor(s): Benedikt Schaefer, Eva Meindl, Sonja Wagner, Herbert Tilg, Heinz Zoller (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - May 20, 2020 Category: Molecular Biology Source Type: research
The changing landscape of iron deficiency
Publication date: Available online 14 May 2020Source: Molecular Aspects of MedicineAuthor(s): Clara Camaschella, Domenico Girelli (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - May 15, 2020 Category: Molecular Biology Source Type: research
NLRP6 inflammasome
Publication date: Available online 6 May 2020Source: Molecular Aspects of MedicineAuthor(s): Runzhi Li, Shu Zhu (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - May 6, 2020 Category: Molecular Biology Source Type: research
To protect or adversely affect? The dichotomous role of the NLRP1 inflammasome in human disease
Publication date: Available online 28 April 2020Source: Molecular Aspects of MedicineAuthor(s): Juselyn D. Tupik, Margaret A. Nagai-Singer, Irving C. Allen (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - April 30, 2020 Category: Molecular Biology Source Type: research
Iron: The cancer connection
Publication date: Available online 25 April 2020Source: Molecular Aspects of MedicineAuthor(s): Suzy V. Torti, Frank M. Torti (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - April 25, 2020 Category: Molecular Biology Source Type: research
Editorial Board
Publication date: April 2020Source: Molecular Aspects of Medicine, Volume 72Author(s): (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - April 11, 2020 Category: Molecular Biology Source Type: research
Editorial Board
Publication date: February 2020Source: Molecular Aspects of Medicine, Volume 71Author(s): (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - February 15, 2020 Category: Molecular Biology Source Type: research
Mitochondrial functions and rare diseases
Publication date: Available online 3 February 2020Source: Molecular Aspects of MedicineAuthor(s): L. Dard, W. Blanchard, C. Hubert, D. Lacombe, R. RossignolAbstractMitochondria are dynamic cellular organelles responsible for a large variety of biochemical processes as energy transduction, REDOX signaling, the biosynthesis of hormones and vitamins, inflammation or cell death execution. Cell biology studies established that 1158 human genes encode proteins localized to mitochondria, as registered in MITOCARTA. Clinical studies showed that a large number of these mitochondrial proteins can be altered in expression and functio...
Source: Molecular Aspects of Medicine - February 4, 2020 Category: Molecular Biology Source Type: research
Integrating circulating miRNA analysis in the clinical management of lung cancer: Present or future?
Publication date: Available online 17 January 2020Source: Molecular Aspects of MedicineAuthor(s): Rita Lampignano, Vera Kloten, Thomas Krahn, Thomas SchlangeAbstractLiquid biopsy holds great promise to complement traditional analysis on cancerous tissue during clinical management of cancer: screening of patients, (early) disease diagnosis, prognosis, therapy selection as well as early response to treatment and disease monitoring. Among emerging circulating biomarkers, cell-free miRNA (cfmiRNA) may have potential in detecting lung cancer and following the course of the disease. Furthermore, several studies highlighted the p...
Source: Molecular Aspects of Medicine - January 18, 2020 Category: Molecular Biology Source Type: research
Circulating cell-free DNA: Translating prostate cancer genomics into clinical care
Publication date: Available online 16 January 2020Source: Molecular Aspects of MedicineAuthor(s): Delila Gasi Tandefelt, Johann de BonoAbstractOnly in the past decade tremendous advances have been made in understanding prostate cancer genomics and consequently in applying new treatment strategies. As options regarding treatments are increasing so are the challenges in selecting the right treatment option for each patient and not the least, understanding the optimal time-point and sequence of applying available treatments. Critically, without reliable methods that enable sequential monitoring of evolving genotypes in indivi...
Source: Molecular Aspects of Medicine - January 17, 2020 Category: Molecular Biology Source Type: research
Macrophage activation as an archetype of mitochondrial repurposing
Publication date: Available online 16 January 2020Source: Molecular Aspects of MedicineAuthor(s): Anthony E. Jones, Ajit S. DivakaruniAbstractMitochondria are metabolic organelles essential not only for energy transduction, but also a range of other functions such as biosynthesis, ion and metal homeostasis, maintenance of redox balance, and cell signaling. A hallmark example of how mitochondria can rebalance these processes to adjust cell function is observed in macrophages. These innate immune cells are responsible for a remarkable breadth of processes including pathogen elimination, antigen presentation, debris clearance...
Source: Molecular Aspects of Medicine - January 17, 2020 Category: Molecular Biology Source Type: research
Emerging roles of β-cell mitochondria in type-2-diabetes
Publication date: Available online 7 January 2020Source: Molecular Aspects of MedicineAuthor(s): Guy Las, Marcus F. Oliveira, Orian S. ShirihaiAbstractType-2-Diabetes (T2D) is the most common metabolic disease in the world today. It erupts as a result of peripheral insulin resistance combined with hyperinsulinemia followed by suppression of insulin secretion from pancreatic β-cells. Mitochondria play a central role in β-cells by sensing glucose and also by mediating the suppression of insulin secretion in T2D. Here, we will summarize the evidence accumulated for the roles of β-cells mitochondria in T2D. We will present ...
Source: Molecular Aspects of Medicine - January 8, 2020 Category: Molecular Biology Source Type: research
Mitochondria: New developments in pathophysiology
Publication date: Available online 30 December 2019Source: Molecular Aspects of MedicineAuthor(s): Alicia J. Kowaltowski, Marcus F. Oliveira (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - December 31, 2019 Category: Molecular Biology Source Type: research
Liquid biopsy analysis in cancer diagnostics
Publication date: Available online 26 December 2019Source: Molecular Aspects of MedicineAuthor(s): Daniel Andersson, Mikael Kubista, Anders Ståhlberg (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - December 27, 2019 Category: Molecular Biology Source Type: research
