High-dimension single-cell analysis applied to cancer
Publication date: Available online 30 August 2017 Source:Molecular Aspects of Medicine Author(s): Lili Wang, Kenneth J. Livak, Catherine J. Wu High-dimension single-cell technology is transforming our ability to study and understand cancer. Numerous studies and reviews have reported advances in technology development. The biological insights gleaned from single-cell technology about cancer biology are less reviewed. Here we focus on research studies that illustrate novel aspects of cancer biology that bulk analysis could not achieve, and discuss the fresh insights gained from the application of single-cell technology ...
Source: Molecular Aspects of Medicine - August 31, 2017 Category: Molecular Biology Source Type: research
The secrets of the cell
Publication date: Available online 24 August 2017 Source:Molecular Aspects of Medicine Author(s): Mikael Kubista, Jacqueline Dreyer-Lamm, Anders Ståhlberg (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - August 24, 2017 Category: Molecular Biology Source Type: research
Corrigendum to “Extracellular ATP and adenosine: The yin and yang in immune responses?” [Molecular Aspects of Medicine 55 (2017) 9-19]
Publication date: Available online 16 August 2017 Source:Molecular Aspects of Medicine Author(s): M.M. Faas, T. Saez, P. de Vos (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - August 17, 2017 Category: Molecular Biology Source Type: research
Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications
Publication date: Available online 4 August 2017 Source:Molecular Aspects of Medicine Author(s): Bian Wu, Giorgio Mottola, Melinda Schaller, Gilbert R. Upchurch, Michael S. Conte Acute vascular injury occurs in a number of important clinical contexts, including spontaneous disease-related events (e.g. plaque rupture, thrombosis) and therapeutic interventions such as angioplasty, stenting, or bypass surgery. Endothelial cell (EC) disruption exposes the underlying matrix, leading to a rapid deposition of platelets, coagulation proteins, and leukocytes. A thrombo-inflammatory response ensues characterized by leukocyte ...
Source: Molecular Aspects of Medicine - August 4, 2017 Category: Molecular Biology Source Type: research
Single-cell RNA sequencing: Technical advancements and biological applications
Publication date: Available online 1 August 2017 Source:Molecular Aspects of Medicine Author(s): Eva Hedlund, Qiaolin Deng Cells are the basic building blocks of organisms and each cell is unique. Single-cell RNA sequencing has emerged as an indispensable tool to dissect the cellular heterogeneity and decompose tissues into cell types and/or cell states, which offers enormous potential for de novo discovery. Single-cell transcriptomic atlases provide unprecedented resolution to reveal complex cellular events and deepen our understanding of biological systems. In this review, we summarize and compare single-cell RNA seq...
Source: Molecular Aspects of Medicine - August 2, 2017 Category: Molecular Biology Source Type: research
