Recommending flavanols and procyanidins for cardiovascular health: Revisited
Publication date: June 2018Source: Molecular Aspects of Medicine, Volume 61Author(s): Javier I. Ottaviani, Christian Heiss, Jeremy P.E. Spencer, Malte Kelm, Hagen SchroeterAbstractThe last 8 years have seen significant developments in our understanding of dietary flavanols and procyanidins in the context of human health and nutrition. During the same time, recognition of the importance of nutrition in primary disease prevention and health maintenance has increased. In addition, the concept of dietary bioactives (food constituents that although not essential to human life and procreation, may nevertheless play an important ...
Source: Molecular Aspects of Medicine - July 5, 2018 Category: Molecular Biology Source Type: research
Berry anthocyanin intake and cardiovascular health
Publication date: June 2018Source: Molecular Aspects of Medicine, Volume 61Author(s): Aedín CassidyAbstractOver half of all cardiovascular (CV) events could be prevented by improved diet. This is reflected in government targets for fruit/vegetable intake, yet these are variable across the world (UK: 5-a-day; USA: 9-a-day), do not identify specific fruits/vegetables, and prove hard to achieve. Mounting evidence from prospective studies, supported by recent randomised controlled trials suggest that the benefits of fruits/vegetables may be due to bioactive substances called flavonoids. Specifically one sub-class of flavonoid...
Source: Molecular Aspects of Medicine - July 5, 2018 Category: Molecular Biology Source Type: research
Cellular and molecular mechanisms of kidney fibrosis
Publication date: Available online 22 June 2018Source: Molecular Aspects of MedicineAuthor(s): Sonja Djudjaj, Peter BoorAbstractRenal fibrosis is the final pathological process common to any ongoing, chronic kidney injury or maladaptive repair. It is considered as the underlying pathological process of chronic kidney disease (CKD), which affects more than 10% of world population and for which treatment options are limited. Renal fibrosis is defined by excessive deposition of extracellular matrix, which disrupts and replaces the functional parenchyma that leads to organ failure. Kidney's histological structure can be divide...
Source: Molecular Aspects of Medicine - July 5, 2018 Category: Molecular Biology Source Type: research
Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications
Publication date: Available online 30 June 2018Source: Molecular Aspects of MedicineAuthor(s): Ralf Weiskirchen, Sabine Weiskirchen, Frank TackeAbstractFibrosis denotes excessive scarring, which exceeds the normal wound healing response to injury in many tissues. Although the extracellular matrix deposition appears unstructured disrupting the normal tissue architecture and subsequently impairing proper organ function, fibrogenesis is a highly orchestrated process determined by defined sequences of molecular signals and cellular response mechanisms. Persistent injury and parenchymal cell death provokes tissue inflammation, ...
Source: Molecular Aspects of Medicine - July 5, 2018 Category: Molecular Biology Source Type: research
PDGF/PDGFR axis in the neural systems
Publication date: August 2018Source: Molecular Aspects of Medicine, Volume 62Author(s): Susmita Sil, Palsamy Periyasamy, Annadurai Thangaraj, Ernest T. Chivero, Shilpa BuchAbstractPlatelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are expressed in several cell types including the brain cells such as neuronal progenitors, neurons, astrocytes, and oligodendrocytes. Emerging evidence shows that PDGF-mediated signaling regulates diverse functions in the central nervous system (CNS) such as neurogenesis, cell survival, synaptogenesis, modulation of ligand-gated ion channels, and development of specific types o...
Source: Molecular Aspects of Medicine - July 5, 2018 Category: Molecular Biology Source Type: research
Editorial Board/Copyright Information
Publication date: August 2018Source: Molecular Aspects of Medicine, Volume 62Author(s): (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - July 5, 2018 Category: Molecular Biology Source Type: research
PDGF-C and PDGF-D signaling in vascular diseases and animal models
Publication date: August 2018Source: Molecular Aspects of Medicine, Volume 62Author(s): Erika Folestad, Anne Kunath, Dick WågsäterAbstractMembers of the platelet-derived growth factor (PDGF) family are well known to be involved in different pathological conditions. The cellular and molecular mechanisms induced by the PDGF signaling have been well studied. Nevertheless, there is much more to discover about their functions and some important questions to be answered. This review summarizes the known roles of two of the PDGFs, PDGF-C and PDGF-D, in vascular diseases. There are clear implications for these growth factors in ...
Source: Molecular Aspects of Medicine - July 5, 2018 Category: Molecular Biology Source Type: research
Platelet-derived growth factor-C and -D in the cardiovascular system and diseases
Publication date: August 2018Source: Molecular Aspects of Medicine, Volume 62Author(s): Chunsik Lee, Xuri LiAbstractThe cardiovascular system is among the first organs formed during development and is pivotal for the formation and function of the rest of the organs and tissues. Therefore, the function and homeostasis of the cardiovascular system are finely regulated by many important molecules. Extensive studies have shown that platelet-derived growth factors (PDGFs) and their receptors are critical regulators of the cardiovascular system. Even though PDGF-C and PDGF-D are relatively new members of the PDGF family, their c...
Source: Molecular Aspects of Medicine - July 5, 2018 Category: Molecular Biology Source Type: research
PDGFs and their receptors in vascular stem/progenitor cells: Functions and therapeutic potential in retinal vasculopathy
Publication date: August 2018Source: Molecular Aspects of Medicine, Volume 62Author(s): Weisi Lu, Xuri LiAbstractVascular stem/progenitor cells (VSCs) include endothelial progenitor cells, smooth muscle progenitor cells, pericytes, and mesenchymal stem cells. VSCs can produce functional and mature vascular cells required to build blood vessels. VSCs therefore play critical roles in vascular repair and regeneration, particularly, in various retinal vasculopathies, in which vascular defects are a devastating pathology. The platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are important regulators of numero...
Source: Molecular Aspects of Medicine - July 5, 2018 Category: Molecular Biology Source Type: research
PDGF-C and PDGF-D in ocular diseases
Publication date: August 2018Source: Molecular Aspects of Medicine, Volume 62Author(s): Anil Kumar, Xuri LiAbstractPDGFs and their receptors are critical regulators of numerous tissues and organs, including the eye. Extensive studies have shown that PDGFs and their receptors play critical roles in many ocular neovascular diseases, such as neovascular age-related macular degeneration, retinopathy of prematurity, and proliferative vitreoretinopathy. In addition, PDGFs and PDGFRs are also important players in ocular diseases involving the degeneration of retinal neuronal and vascular cells, such as glaucoma and retinitis pigm...
Source: Molecular Aspects of Medicine - July 5, 2018 Category: Molecular Biology Source Type: research
PDGF in organ fibrosis
Publication date: August 2018Source: Molecular Aspects of Medicine, Volume 62Author(s): Barbara Mara Klinkhammer, Jürgen Floege, Peter BoorAbstractFibrosis is part of a tissue repair response to injury, defined as increased deposition of extracellular matrix. In some instances, fibrosis is beneficial; however, in the majority of diseases fibrosis is detrimental. Virtually all chronic progressive diseases are associated with fibrosis, representing a huge number of patients worldwide. Fibrosis occurs in all organs and tissues, becomes irreversible with time and further drives loss of tissue function. Various cells types ini...
Source: Molecular Aspects of Medicine - July 5, 2018 Category: Molecular Biology Source Type: research
The PDGF/PDGFR pathway as a drug target
Publication date: August 2018Source: Molecular Aspects of Medicine, Volume 62Author(s): Natalia Papadopoulos, Johan LennartssonAbstractPlatelet-derived growth factors (PDGF) promotes cell proliferation, survival and migration, primarily of cells of mesenchymal origin. Dysfunction of PDGF signaling has been observed in a wide array of pathological conditions, such as cancer, fibrosis, neurological conditions and atherosclerosis. Reported abnormalities of the PDGF pathway include overexpression or amplification of PDGF receptors (PDGFRs), gain of function point mutations or activating chromosomal translocations. Current deve...
Source: Molecular Aspects of Medicine - July 5, 2018 Category: Molecular Biology Source Type: research
Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications
Publication date: Available online 30 June 2018 Source:Molecular Aspects of Medicine Author(s): Ralf Weiskirchen, Sabine Weiskirchen, Frank Tacke Fibrosis denotes excessive scarring, which exceeds the normal wound healing response to injury in many tissues. Although the extracellular matrix deposition appears unstructured disrupting the normal tissue architecture and subsequently impairing proper organ function, fibrogenesis is a highly orchestrated process determined by defined sequences of molecular signals and cellular response mechanisms. Persistent injury and parenchymal cell death provokes tissue inflammation, m...
Source: Molecular Aspects of Medicine - June 30, 2018 Category: Molecular Biology Source Type: research
Cellular and molecular mechanisms of kidney fibrosis
Publication date: Available online 22 June 2018 Source:Molecular Aspects of Medicine Author(s): Sonja Djudjaj, Peter Boor Renal fibrosis is the final pathological process common to any ongoing, chronic kidney injury or maladaptive repair. It is considered as the underlying pathological process of chronic kidney disease (CKD), which affects more than 10% of world population and for which treatment options are limited. Renal fibrosis is defined by excessive deposition of extracellular matrix, which disrupts and replaces the functional parenchyma that leads to organ failure. Kidney's histological structure can be divided ...
Source: Molecular Aspects of Medicine - June 23, 2018 Category: Molecular Biology Source Type: research
Bioactives and their impact on human health
Publication date: June 2018 Source:Molecular Aspects of Medicine, Volume 61 Author(s): Cesar G. Fraga, Patricia I. Oteiza (Source: Molecular Aspects of Medicine)
Source: Molecular Aspects of Medicine - June 14, 2018 Category: Molecular Biology Source Type: research
