Importance of a moderate plate-to-bone distance for the functioning of the far cortical locking system
The main objective of any bone fixation device is to achieve fracture union. Conventional methods that use dynamic compression plates rely on a very rigid construct to allow direct bone healing. In recent decades, the internal fixation of long bone fractures has developed, and now involves biological, rather than mechanical methods; thus, more flexible constructs are favored to induce secondary bone healing by callus formation [1 –3]. With the introduction of locking compression plates as a fixed-angle screw locked mechanism, this technique avoids the need for precise reduction and plate compression against the underlyin...
Source: Medical Engineering and Physics - April 20, 2018 Category: Biomedical Engineering Authors: Jesse Chieh-Szu Yang, Kang-Ping Lin, Hung-Wen Wei, Wen-Chuan Chen, Chao-Ching Chiang, Ming-Chau Chang, Cheng-Lun Tsai, Kun-Jhih Lin Tags: Technical note Source Type: research

Three-dimensional printing as a technology supporting the treatment of lower limb deformity and shortening with the Ilizarov method
Orthopedists should consider differences between the expected and actual lengthening and axial correction in planning treatment with the Ilizarov method. Three-dimensional printing is a useful technology that can be used to support treatment with the Ilizarov method. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - April 20, 2018 Category: Biomedical Engineering Authors: Piotr Morasiewicz, Karolina Burzy ńska, Wiktor Orzechowski, Szymon Łukasz Dragan, Szymon Feliks Dragan, Jarosław Filipiak Tags: Technical note Source Type: research

Kinect V2 implementation and testing of the reaching performance scale for motor evaluation of patients with neurological impairment
In a clinical environment, standard tools for the assessments are clinical scales [1]. Clinical scales are surveys and questionnaires that assess body function, activity and participation issues according to the International Classification of Functioning (ICF) [2, 3]. Clinical scales are inter and intra operator dependent and have intrinsic low sensibility and suffer from ceiling and floor effects [4,5]. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - April 19, 2018 Category: Biomedical Engineering Authors: Alessandro Scano, Andrea Chiavenna, Matteo Malosio, Lorenzo Molinari Tosatti, Franco Molteni Tags: Short Communication Source Type: research

Formation of microcapsules by ultrasound stimulation for use in remote-controlled drug-eluting stents
Coronary Heart Disease (CHD) is a global health challenge, resulting in around 17.3 million deaths annually [1]. The placement of stents in diseased coronary arteries is the most successful minimally-invasive intervention to treat CHD. The most advanced stents are drug-eluting stents (DES), which release a drug to inhibit the excessive smooth muscle proliferative process responsible for the inconsistent results achieved with bare metal stents. However, there is evidence that DES prevent regrowth of the endothelial cell layer (endothelium) that lines the innermost layer of the artery and it is increasingly clear that regene...
Source: Medical Engineering and Physics - April 18, 2018 Category: Biomedical Engineering Authors: Wei Yao, Yan Bao, Yu Chen Tags: Technical Note Source Type: research

Development and characterization of a point-of care rate-based transcutaneous respiratory status monitor
Partial pressures of arterial oxygen (paO2) and carbon dioxide (paCO2) are two of the most important respiratory parameters in intensive care. PaO2 reflects the adequacy of oxygen delivery to the blood via lungs, and paCO2 reflects the adequacy of ventilation to clear the metabolic byproducts from blood. Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply. Severe hypoxia can cause multiple organ failure or even death. Hyperoxia occurs when tissues and organs are exposed to an excess supply of oxygen or higher than normal partial pressure of oxygen, and can lead to oxygen t...
Source: Medical Engineering and Physics - April 5, 2018 Category: Biomedical Engineering Authors: Xudong Ge, Prosper Adangwa, Ja Young Lim, Yordan Kostov, Leah Tolosa, Richard Pierson, Daniel Herr, Govind Rao Tags: Technical note Source Type: research

Biomechanical analysis of bone remodeling following mandibular reconstruction using fibula free flap
Free vascularized osteocutaneous tissue transfer has become a well-established procedure for maxillomandibular reconstruction following large resection due to trauma, atrophy, and tumors ablation [1,2]. Fibula free flap (FFF) provides superior length and long vascular pedicles for mandibular reconstruction, with proven subsequent high reliability and adaptability [3]. Nevertheless, some clinical complications remain with delayed or poor union between the grafted fibula bone and host native mandible [4,5]. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - March 30, 2018 Category: Biomedical Engineering Authors: Nobuhiro Yoda, Keke Zheng, Junning Chen, Zhipeng Liao, Shigeto Koyama, Christopher Peck, Michael Swain, Keiichi Sasaki, Qing Li Source Type: research

Augmented reality fluoroscopy simulation of the guide-wire insertion in DHS surgery: A proof of concept study
Hip fractures contribute to a significant clinical burden globally with over 1.6 million cases per annum [1]. Domestically, 70,000 patients fracture their hip in the UK each year, resulting in £2 billion of care [2]. These fractures carry a high morbidity and mortality, with up to a 30% mortality rate within 1 year [3–6]. Additionally, after hip fracture, patients are five times more likely to be institutionalised at one year than their age-matched controls [7]. Extracapsular fractures account for a significant subsection of neck of femur fractures. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - March 29, 2018 Category: Biomedical Engineering Authors: B.H. van Duren, K. Sugand, R. Wescott, R. Carrington, A. Hart Tags: Technical note Source Type: research

Experimental and numerical study of platelets rolling on a von Willebrand factor-coated surface
Platelets are small anucleated blood cells that have an essential role in the process of hemostasis. In a wounded vessel, platelets adhere to the wall through ligand –receptor interactions and initiate coagulation. The large multimeric protein von Willebrand factor (vWF) is such a ligand [1]. At high shear rates, vWF unfolds and exposes platelet-binding domains [2,3]. The resulting platelet–vWF bonds are transient, causing platelets to roll along a vWF-expre ssing wall [4,5]. vWF can also mediate firm adhesion through interaction with activated integrin αIIbβ3 [6]. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - March 26, 2018 Category: Biomedical Engineering Authors: Justine S. Pujos, Mathilde Reyssat, Anne Le Goff Source Type: research

Comparison of in vivo vs. ex situ obtained material properties of sheep common carotid artery
Preoperative planning can be of critical importance and often determine the outcome of a surgical procedure. Without doubt, this process should be as patient-specific as possible. Patient-specific anatomical geometry is already used in the clinic for orthopaedic procedures (e.g. hip [1,2] and knee arthroplasty [3,4]), dental implants [5,6], reconstructive surgery [7,8], etc. In cardiovascular surgery, the most prominent applications are stenting procedures [9 –11], valve replacements [12] and aneurysm repair [13]. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - March 24, 2018 Category: Biomedical Engineering Authors: Marija Smoljki ć, Peter Verbrugghe, Matilda Larsson, Erik Widman, Heleen Fehervary, Jan D’hooge, Jos Vander Sloten, Nele Famaey Source Type: research