Journals of Gerontology Series A: Biological Sciences and Medical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Biological
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - September 10, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Retraction
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Tags: Retraction Source Type: research

Melatonin Secretion and Muscle Strength in Elderly Individuals: A Cross-Sectional Study of the HEIJO-KYO Cohort
Conclusions: Melatonin secretion was significantly associated with muscle strength in this elderly population. Further longitudinal studies are needed to ascertain the effect of melatonin levels on muscle strength. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Authors: Obayashi, K., Saeki, K., Maegawa, T., Iwamoto, J., Sakai, T., Otaki, N., Kataoka, H., Kurumatani, N. Tags: Research Article Source Type: research

Incidence of Hip Fracture in U.S. Nursing Homes
Conclusions: In nursing home residents surviving 100 days or more in a facility, the incidence of hip fracture is high, particularly among older white, Native American, and newly admitted residents. This is the first nationwide study to provide sex- and age-specific estimates among U.S. nursing home residents, and it underscores the magnitude of the problem. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Authors: Berry, S. D., Lee, Y., Zullo, A. R., Kiel, D. P., Dosa, D., Mor, V. Tags: Research Article Source Type: research

Glucose Levels and Risk of Frailty
Conclusion: Higher glucose levels may be a risk factor for frailty in older adults without diabetes. The apparent U-shape association between glucose levels and frailty in people with diabetes is consistent with the literature on glycemia and mortality and deserves further examination. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Authors: Zaslavsky, O., Walker, R. L., Crane, P. K., Gray, S. L., Larson, E. B. Tags: Research Article Source Type: research

Obesity and Structural Brain Integrity in Older Women: The Womens Health Initiative Magnetic Resonance Imaging Study
Conclusions: Obesity in this cohort is associated with less brain atrophy and lower ischemic lesion loads. The findings are consistent with our previous report of worse cognitive performance in association with weight loss (probably not due to frailty) in this cohort and in line with the idea of the "obesity paradox" as differences in dementia risk vary across time, whereby midlife obesity seems to be a predictor of dementia, whereas weight loss seems to be a better predictor at older ages. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Authors: Driscoll, I., Gaussoin, S. A., Wassertheil-Smoller, S., Limacher, M., Casanova, R., Yaffe, K., Resnick, S. M., Espeland, M. A. Tags: Research Article Source Type: research

Regional Hippocampal Atrophy and Higher Levels of Plasma Amyloid-Beta Are Associated With Subjective Memory Complaints in Nondemented Elderly Subjects
Conclusions: The presence of SMC, lower volumes of specific hippocampal regions, and higher plasma Aβ1–42 levels could be conditions associated with aging vulnerability. If such associations are confirmed in longitudinal studies, the combination may be markers recommending clinical follow-up in nondemented older adults. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Authors: Cantero, J. L., Iglesias, J. E., Van Leemput, K., Atienza, M. Tags: Research Article Source Type: research

Bioavailable Testosterone Linearly Declines Over A Wide Age Spectrum in Men and Women From The Baltimore Longitudinal Study of Aging
Conclusion: In both men and women, mBT linearly declines over the life span and even at old ages. Its relationship with age-related phenotypes should be further investigated. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Authors: Fabbri, E., An, Y., Gonzalez-Freire, M., Zoli, M., Maggio, M., Studenski, S. A., Egan, J. M., Chia, C. W., Ferrucci, L. Tags: Research Article Source Type: research

Assessment of the Effects of Age, Gender, and Exercise Training on the Cardiac Sympathetic Nervous System Using Positron Emission Tomography Imaging
Conclusion: With age, presynaptic uptake as measured by PSnt declines, but there were no differences in β'max. Endurance training significantly increased VO2 max but did not cause any changes in the measures of cardiac sympathetic nervous system function. These findings suggest that significant changes do not occur or that current PET imaging methods may be inadequate to measure small serial differences in a highly reproducible manner. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Authors: Bernacki, G. M., Bahrainy, S., Caldwell, J. H., Levy, W. C., Link, J. M., Stratton, J. R. Tags: Research Article Source Type: research

Age-Related Change in Mobility: Perspectives From Life Course Epidemiology and Geroscience
Mobility is the most studied and most relevant physical ability affecting quality of life with strong prognostic value for disability and survival. Natural selection has built the "engine" of mobility with great robustness, redundancy, and functional reserve. Efficient patterns of mobility can be acquired during development even by children affected by severe impairments. Analogously, age-associated impairments in mobility-related physiological systems are compensated and overt limitations of mobility only occur when the severity can no longer be compensated. Mobility loss in older persons usually results from multiple imp...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Authors: Ferrucci, L., Cooper, R., Shardell, M., Simonsick, E. M., Schrack, J. A., Kuh, D. Tags: Review Source Type: research

A Prospective Study of Back Pain and Risk of Falls Among Older Community-dwelling Women
Conclusions. Older community-dwelling women with a recent history of back pain are at increased risk for falls. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Authors: Marshall, L. M., Litwack-Harrison, S., Cawthon, P. M., Kado, D. M., Deyo, R. A., Makris, U. E., Carlson, H. L., Nevitt, M. C., for the Study of Osteoporotic Fractures (SOF) Research Group Tags: Research Article Source Type: research

Life Expectancy With and Without Pain in the U.S. Elderly Population
Conclusion: Pain is moderately associated with quantity of or total life but substantially and importantly associated with quality of or pain-free life. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Authors: Zimmer, Z., Rubin, S. Tags: Research Article Source Type: research

Acacetin 7-O-{alpha}-l-rhamnopyranosyl (1-2) {beta}-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans
This study is the first time report on longevity-promoting activity of ARX in C. elegans mediated by stress and DR-regulating genes. This novel phytomolecule can contribute in designing therapeutics for managing aging and age-related diseases. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Authors: Asthana, J., Yadav, D., Pant, A., Yadav, A. K., Gupta, M. M., Pandey, R. Tags: Original Article Source Type: research

Genetic Variants in KLOTHO Associate With Cognitive Function in the Oldest Old Group
Decline in cognitive abilities is a major concern in aging individuals. A potential important factor for functioning of the central nervous system in late-life stages is the KLOTHO (KL) gene. KL is expressed in various organs including the brain and is involved in multiple biological processes, for example, growth factor signaling. In the present study, 19 tagging gene variants in KL were studied in relation to 2 measures of cognitive function, a 5-item cognitive composite score and the Mini Mental State Examination, in 1,480 Danes 92–100 years of age. We found that heterozygotes for the previously reported KL-VS had...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Authors: Mengel-From, J., Soerensen, M., Nygaard, M., McGue, M., Christensen, K., Christiansen, L. Tags: Original Article Source Type: research

Left Atrial Volume and Pulmonary Artery Diameter Are Noninvasive Measures of Age-Related Diastolic Dysfunction in Mice
Impaired cardiac diastolic function occurs with aging in many species and may be difficult to measure noninvasively. In humans, left atrial (LA) volume is a robust measure of chronic diastolic function as the LA is exposed to increased left ventricular filling pressures. We hypothesized that LA volume would be a useful indicator of diastolic function in aging mice. Further, we asked whether pressures were propagated backwards affecting pulmonary arteries (PAs) and right ventricle (RV). We measured LA, PA, and RV infundibulum dimensions with echocardiography and used mouse-specific Doppler systems and pressure catheters for...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Authors: Medrano, G., Hermosillo-Rodriguez, J., Pham, T., Granillo, A., Hartley, C. J., Reddy, A., Osuna, P. M., Entman, M. L., Taffet, G. E. Tags: Original Article Source Type: research