Journals of Gerontology Series A: Biological Sciences and Medical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Association of Physical Activity History With Physical Function and Mortality in Old Age
Conclusions. Higher cumulative physical activity over the life course was associated with less decline in physical performance and reduced rate of incident mobility disability and mortality in older ages. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - March 7, 2016 Category: Geriatrics Authors: Stenholm, S., Koster, A., Valkeinen, H., Patel, K. V., Bandinelli, S., Guralnik, J. M., Ferrucci, L. Tags: Research Article Source Type: research

Physical Resilience in Older Adults: Systematic Review and Development of an Emerging Construct
Conclusions. Current biomedical literature lacks consensus on how to define and measure physical resilience. We propose a working definition of physical resilience at the whole person level: a characteristic which determines one’s ability to resist or recover from functional decline following health stressor(s). We present a conceptual framework that encompasses the related construct of physiologic reserve. We discuss gaps and opportunities in measurement, interactions across contributors to physical resilience, and points of intervention. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - March 7, 2016 Category: Geriatrics Authors: Whitson, H. E., Duan-Porter, W., Schmader, K. E., Morey, M. C., Cohen, H. J., Colon-Emeric, C. S. Tags: Review Source Type: research

Acknowledgment of Reviewers
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - March 7, 2016 Category: Geriatrics Tags: Acknowledgement of Referees Source Type: research

Myocardial Infarction Superimposed on Aging: MMP-9 Deletion Promotes M2 Macrophage Polarization
In conclusion, MMP-9 deletion stimulated anti-inflammatory polarization of macrophages to attenuate left ventricle dysfunction in the aging post–myocardial infarction. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - March 7, 2016 Category: Geriatrics Authors: Yabluchanskiy, A., Ma, Y., DeLeon-Pennell, K. Y., Altara, R., Halade, G. V., Voorhees, A. P., Nguyen, N. T., Jin, Y.-F., Winniford, M. D., Hall, M. E., Han, H.-C., Lindsey, M. L. Tags: Original Article Source Type: research

Calculating the Rate of Senescence From Mortality Data: An Analysis of Data From the ERA-EDTA Registry
In conclusion, the rate of senescence can be calculated directly from non-modeled mortality rates, overcoming the disadvantages of an indirect estimation based on modeled mortality rates. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - March 7, 2016 Category: Geriatrics Authors: Koopman, J. J. E., Rozing, M. P., Kramer, A., Abad, J. M., Finne, P., Heaf, J. G., Hoitsma, A. J., De Meester, J. M. J., Palsson, R., Postorino, M., Ravani, P., Wanner, C., Jager, K. J., van Bodegom, D., Westendorp, R. G. J. Tags: Original Article Source Type: research

Aged Muscle Demonstrates Fiber-Type Adaptations in Response to Mechanical Overload, in the Absence of Myofiber Hypertrophy, Independent of Satellite Cell Abundance
Although sarcopenia, age-associated loss of muscle mass and strength, is neither accelerated nor exacerbated by depletion of muscle stem cells, satellite cells, we hypothesized that adaptation in sarcopenic muscle would be compromised. To test this hypothesis, we depleted satellite cells with tamoxifen treatment of Pax7CreER-DTA mice at 4 months of age, and 20 months later subjected the plantaris muscle to 2 weeks of mechanical overload. We found myofiber hypertrophy was impaired in aged mice regardless of satellite cell content. Even in the absence of growth, vehicle-treated mice mounted a regenerative response, not appar...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - March 7, 2016 Category: Geriatrics Authors: Lee, J. D., Fry, C. S., Mula, J., Kirby, T. J., Jackson, J. R., Liu, F., Yang, L., Dupont-Versteegden, E. E., McCarthy, J. J., Peterson, C. A. Tags: Original Article Source Type: research

Long-Lived {alpha}MUPA Mice Show Reduced Sexual Dimorphism in Lifespan, and in Energy and Circadian Homeostasis-Related Parameters
Female αMUPA (alpha murine urokinase-like plasminogen activator) transgenic mice show increased lifespan, reduced body weight and food intake, and high-amplitude circadian rhythms with an endogenous period length (tau) of 24h, versus their wild types (WT) showing a 23.7-h tau. Our goal was to characterize αMUPA and WT male mice, and their in-strain sexual dimorphism, and to further understand the mechanisms underlying αMUPA’s longevity. Male αMUPA mice showed increased lifespan, reduced body weight and food intake, and aligned endogenous rhythm with a tau of 24.0h versus a tau <24h in WT. H...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - March 7, 2016 Category: Geriatrics Authors: Steckler, R., Shabtay-Yanai, A., Pinsky, M., Rauch, M., Tamir, S., Gutman, R. Tags: Original Article Source Type: research

Relationship Between Mitochondrial DNA Mutations and Aging. Estimation of Age-at-death
Some studies have pointed to the relationship between mitochondrial DNA (mtDNA) mutations and age in different tissues, which are potentially interesting in aging research and in forensic identification because they could help to improve the estimation of age-at-death. The present study aims to evaluate the mutations in mtDNA from dentin and pulp and their relation with age. Healthy erupted third molars were extracted from individuals from two Spanish populations, aged 20–70. When analyzing the amplification of hypervariable region 2 of the mtDNA by real-time polymerase chain reaction, a negative strong linear correl...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - March 7, 2016 Category: Geriatrics Authors: Zapico, S. C., Ubelaker, D. H. Tags: Brief Report Source Type: research

Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society
Although the demographic revolution has produced hundreds of millions people aged 65 and older, a substantial segment of that population is not enjoying the benefits of extended healthspan. Many live with multiple chronic conditions and disabilities that erode the quality of life. The consequences are also costly for society. In the United States, the most costly 5% of Medicare beneficiaries account for approximately 50% of Medicare’s expenditures. This perspective summarizes a recent workshop on biomedical approaches to best extend healthspan as way to reduce age-related dysfunction and disability. We further specif...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - March 7, 2016 Category: Geriatrics Authors: Nikolich-Zugich, J., Goldman, D. P., Cohen, P. R., Cortese, D., Fontana, L., Kennedy, B. K., Mohler, M. J., Olshansky, S. J., Perls, T., Perry, D., Richardson, A., Ritchie, C., Wertheimer, A. M., Faragher, R. G. A., Fain, M. J. Tags: Perspective Source Type: research

The Geropathology Research Network: An Interdisciplinary Approach for Integrating Pathology Into Research on Aging
Geropathology is the study of aging and age-related lesions and diseases in the form of whole necropsies/autopsies, surgical biopsies, histology, and molecular biomarkers. It encompasses multiple subspecialties of geriatrics, anatomic pathology, molecular pathology, clinical pathology, and gerontology. In order to increase the consistency and scope of communication in the histologic and molecular pathology assessment of tissues from preclinical and clinical aging studies, a Geropathology Research Network has been established consisting of pathologists and scientists with expertise in the comparative pathology of aging, the...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - March 7, 2016 Category: Geriatrics Authors: Ladiges, W., Ikeno, Y., Niedernhofer, L., McIndoe, R. A., Ciol, M. A., Ritchey, J., Liggitt, D. Tags: Perspective Source Type: research

Measures of Healthspan as Indices of Aging in Mice--A Recommendation
In this report, we describe the utility and the limitations of assays in mice currently available for measuring a wide range of physiological functions that potentially impact quality of life. We encourage investigators and reviewers alike to expect at minimum an overall assessment of health in several domains across several ages before an intervention is labeled as "increasing healthspan." In addition, it is important that investigators indicate any tests in which the treated group did worse or did not differ statistically from controls because overall health is a complex phenotype, and no intervention discovered to date ...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - March 7, 2016 Category: Geriatrics Authors: Richardson, A., Fischer, K. E., Speakman, J. R., de Cabo, R., Mitchell, S. J., Peterson, C. A., Rabinovitch, P., Chiao, Y. A., Taffet, G., Miller, R. A., Renteria, R. C., Bower, J., Ingram, D. K., Ladiges, W. C., Ikeno, Y., Sierra, F., Austad, S. N. Tags: Perspective Source Type: research

Standardized, Multidisciplinary Approaches for the Study of Aging Biology and for Translation of Aging Interventions
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - March 7, 2016 Category: Geriatrics Authors: Hilmer, S. N., Le Couteur, D. G. Tags: Guest Editorial Source Type: research

Subscription Page
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - March 7, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Medical Sciences Table of Contents
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - March 7, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Medical
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - March 7, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research