Journals of Gerontology Series A: Biological Sciences and Medical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Prevalence of Combined Somatic and Mental Health Multimorbidity: Patterns by Age, Sex, and Race/Ethnicity
Conclusions: SMM that reaches medical attention is highly prevalent across all age groups, is more frequent in women, is less frequent in Asians, and encompasses a wide range of conditions. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - October 7, 2016 Category: Geriatrics Authors: Bobo, W. V., Yawn, B. P., St. Sauver, J. L., Grossardt, B. R., Boyd, C. M., Rocca, W. A. Tags: Research Article Source Type: research

Disentangling Cognitive-Frailty: Results From the Gait and Brain Study
Conclusions: Combining a simple motor test, such as gait velocity, with a reliable cognitive test like the Montreal Cognitive Assessment is superior than the cognitive-frailty construct to detect individuals at risk for dementia. Cognitive-frailty may embody two different manifestations, slow gait and low cognition, of a common underlying mechanism. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - October 7, 2016 Category: Geriatrics Authors: Montero-Odasso, M. M., Barnes, B., Speechley, M., Muir Hunter, S. W., Doherty, T. J., Duque, G., Gopaul, K., Sposato, L. A., Casas-Herrero, A., Borrie, M. J., Camicioli, R., Wells, J. L. Tags: Research Article Source Type: research

Cystatin C and Objectively Measured Mobility 10 Years Later in Older Women
Conclusions: Lower cysC in older women is independently associated with good mobility 10 years later and may be a biomarker for successful aging as manifested by preservation of lower extremity performance in late life. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - October 7, 2016 Category: Geriatrics Authors: Ensrud, K. E., Lui, L.-Y., Cawthon, P., Fredman, L., Slinin, Y., Hillier, T., Cauley, J., Canales, M., for the Study of Osteoporotic Fractures Tags: Brief Report Source Type: research

Objectively Measured Physical Activity and Changes in Life-Space Mobility Among Older People
Conclusions: In old age, more time spent walking outdoors and accumulation of moderate-intensity physical activity may help to maintain higher life-space mobility, a correlate of good quality of life. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - October 7, 2016 Category: Geriatrics Authors: Tsai, L.-T., Rantakokko, M., Rantanen, T., Viljanen, A., Kauppinen, M., Portegijs, E. Tags: Research Article Source Type: research

Can a Body-Fixed Sensor Reduce Heisenbergs Uncertainty When It Comes to the Evaluation of Mobility? Effects of Aging and Fall Risk on Transitions in Daily Living
Conclusions: Features extracted from the multiple transitions recorded during daily living apparently reflect changes associated with aging and fall risk. Long-term monitoring of temporal features and their distribution may be helpful to provide a more complete and accurate assessment of the effects of aging and fall risk on daily function and mobility. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - October 7, 2016 Category: Geriatrics Authors: Iluz, T., Weiss, A., Gazit, E., Tankus, A., Brozgol, M., Dorfman, M., Mirelman, A., Giladi, N., Hausdorff, J. M. Tags: Research Practice Source Type: research

Aging, the Central Nervous System, and Mobility in Older Adults: Interventions
Conclusions: In order to develop effective preventive interventions for this prevalent syndrome, multidisciplinary teams are essential particularly because of the complex nature of the syndrome. Additionally, integrating innovative methods into the design of interventions may help researchers better measure complex mechanisms, and finally, the value of understanding the link between the CNS and mobility should be conveyed to researchers across disciplines in order to incorporate cognitive and mobility measurements into study protocols. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - October 7, 2016 Category: Geriatrics Authors: Varma, V. R., Hausdorff, J. M., Studenski, S. A., Rosano, C., Camicioli, R., Alexander, N. B., Chen, W. G., Lipsitz, L. A., Carlson, M. C. Tags: Special Article Source Type: research

Metabolic Rate and Perceived Exertion of Walking in Older Adults With Idiopathic Chronic Fatigue
Conclusions: This study suggests that ICF in older adults is not related to elevated metabolic cost of walking. Higher RPE without concomitant decreases in performance indicate a potential disconnect between metabolic output and sensations during movement. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - October 7, 2016 Category: Geriatrics Authors: Valiani, V., Corbett, D. B., Knaggs, J. D., Manini, T. M. Tags: Research Article Source Type: research

Relationship of Objectively-Measured Habitual Physical Activity to Chronic Inflammation and Fatigue in Middle-Aged and Older Adults
Conclusions: Levels of habitual PA are lower in middle-aged and older adults with higher levels of chronic inflammation and greater self-reported fatigue. In addition, participants who experienced greater declines in inflammation during the interventions had greater declines in fatigue and larger increases in PA. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - October 7, 2016 Category: Geriatrics Authors: Nicklas, B. J., Beavers, D. P., Mihalko, S. L., Miller, G. D., Loeser, R. F., Messier, S. P. Tags: Research Article Source Type: research

Strategies and Challenges in Clinical Trials Targeting Human Aging
Interventions that target fundamental aging processes have the potential to transform human health and health care. A variety of candidate drugs have emerged from basic and translational research that may target aging processes. Some of these drugs are already in clinical use for other purposes, such as metformin and rapamycin. However, designing clinical trials to test interventions that target the aging process poses a unique set of challenges. This paper summarizes the outcomes of an international meeting co-ordinated by the NIH-funded Geroscience Network to further the goal of developing a translational pipeline to mov...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - October 7, 2016 Category: Geriatrics Authors: Newman, J. C., Milman, S., Hashmi, S. K., Austad, S. N., Kirkland, J. L., Halter, J. B., Barzilai, N. Tags: Special Issue: Moving Geroscience Into Uncharted Waters: Perspective Source Type: research

Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes
This article summarizes the outcomes of an international meeting partly funded through the NIH R24 Geroscience Network, whose purpose was to generate concepts and frameworks for early, proof-of-concept clinical trials for therapeutic interventions that target fundamental processes of aging. The goals of proof-of-concept trials include generating preliminary signals of efficacy in an aging-related disease or outcome that will reduce the risk of conducting larger trials, contributing data and biological samples to support larger-scale research by strategic networks, and furthering a dialogue with regulatory agencies on appro...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - October 7, 2016 Category: Geriatrics Authors: Justice, J., Miller, J. D., Newman, J. C., Hashmi, S. K., Halter, J., Austad, S. N., Barzilai, N., Kirkland, J. L. Tags: Special Issue: Moving Geroscience Into Uncharted Waters: Perspective Source Type: research

Resilience in Aging Mice
Recently discovered interventions that target fundamental aging mechanisms have been shown to increase life span in mice and other species, and in some cases, these same manipulations have been shown to enhance health span and alleviate multiple age-related diseases and conditions. Aging is generally associated with decreases in resilience, the capacity to respond to or recover from clinically relevant stresses such as surgery, infections, or vascular events. We hypothesize that the age-related increase in susceptibility to those diseases and conditions is driven by or associated with the decrease in resilience. Thus, a te...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - October 7, 2016 Category: Geriatrics Authors: Kirkland, J. L., Stout, M. B., Sierra, F. Tags: Special Issue: Moving Geroscience Into Uncharted Waters: Perspective Source Type: research

Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience
Life extension is no longer considered sufficient evidence of delayed aging in research animals. It must also be demonstrated that a broad swathe of health indicators have been extended. During a retreat of the Geroscience Network, a consortium of basic and clinical aging researchers, potential measures of mouse health were considered for their potential as easily standardized, highly informative metrics. Major health domains considered were neuromuscular, cognitive, cardiovascular, metabolic, and inflammatory functions as well as body composition and energetics and a multitude of assays interrogating these domains. A part...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - October 7, 2016 Category: Geriatrics Authors: Huffman, D. M., Justice, J. N., Stout, M. B., Kirkland, J. L., Barzilai, N., Austad, S. N. Tags: Special Issue: Moving Geroscience Into Uncharted Waters: Perspective Source Type: research

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms
This report summarizes discussions held at a 2014 Geroscience Network retreat focused on identifying hurdles that currently impede the preclinical development of drugs targeting fundamental aging processes. From these discussions, it was evident that aging researchers have varied perceptions of the ideal preclinical pipeline. To forge a clear and cohesive path forward, several areas of controversy must first be resolved and new tools developed. Here, we focus on five key issues in preclinical drug development (drug discovery, lead compound development, translational preclinical biomarkers, funding, and integration between ...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - October 7, 2016 Category: Geriatrics Authors: Burd, C. E., Gill, M. S., Niedernhofer, L. J., Robbins, P. D., Austad, S. N., Barzilai, N., Kirkland, J. L. Tags: Special Issue: Moving Geroscience Into Uncharted Waters: Perspective Source Type: research

Moving Geroscience Into Uncharted Waters
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - October 7, 2016 Category: Geriatrics Authors: Sierra, F. Tags: Special Issue: Moving Geroscience Into Uncharted Waters: Guest Editorial Source Type: research

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Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - October 7, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research