Journals of Gerontology Series A: Biological Sciences and Medical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Effects of an Updated Preventive Home Visit Program Based on a Systematic Structured Assessment of Care Needs for Ambulatory Frail Older Adults in Japan: A Randomized Controlled Trial
Conclusions: These results suggest that the updated preventive home visit program could be effective for the prevention of ADL and care-needs deterioration, and these effects could continue up to 1 year after program completion. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - November 11, 2016 Category: Geriatrics Authors: Kono, A., Izumi, K., Yoshiyuki, N., Kanaya, Y., Rubenstein, L. Z. Tags: Research Article Source Type: research

Declines and Impairment in Executive Function Predict Onset of Physical Frailty
Conclusions: Findings inform the association of executive functioning with transitions to frailty, suggesting both impairments in and declines in executive functioning are associated with risk of frailty onset. It remains to be determined whether these associations are causal or whether shared aging related or other mechanisms are involved. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - November 11, 2016 Category: Geriatrics Authors: Gross, A. L., Xue, Q.-L., Bandeen-Roche, K., Fried, L. P., Varadhan, R., McAdams-DeMarco, M. A., Walston, J., Carlson, M. C. Tags: Research Article Source Type: research

An Evaluation of the Longitudinal, Bidirectional Associations Between Gait Speed and Cognition in Older Women and Men
Conclusions: The results indicate declining gait speed as a precursor to declining cognitive functioning, and suggest a weaker reciprocal process among older women and men. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - November 11, 2016 Category: Geriatrics Authors: Best, J. R., Liu-Ambrose, T., Boudreau, R. M., Ayonayon, H. N., Satterfield, S., Simonsick, E. M., Studenski, S., Yaffe, K., Newman, A. B., Rosano, C., for the Health, Aging and Body Composition Study Tags: Research Article Source Type: research

Trajectories of Lower Extremity Physical Performance: Effects on Fractures and Mortality in Older Women
Conclusions: Greatest declines in walking speed and chair stand speed were both associated with an increased risk of hip fracture and mortality independent of PF_age80 and other important confounders. Both physical performance change and the single physical performance measurement should be considered in the etiology of hip fracture and mortality. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - November 11, 2016 Category: Geriatrics Authors: Barbour, K. E., Lui, L.-Y., McCulloch, C. E., Ensrud, K. E., Cawthon, P. M., Yaffe, K., Barnes, D. E., Fredman, L., Newman, A. B., Cummings, S. R., Cauley, J. A., for the Study of Osteoporotic Fractures Tags: Research Article Source Type: research

The Association Between Obesity and Cognitive Function in Older Persons: How Much Is Mediated by Inflammation, Fasting Plasma Glucose, and Hypertriglyceridemia?
Conclusions: There is a weak positive association between obesity and cognitive performance in older persons, which is partially antagonized by inflammation and elevated fasting plasma glucose, but not hypertriglyceridemia. Further studies are needed to elucidate whether this is due to selection bias, or truly reflects biologically complex and counter balancing pathways involved in obesity. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - November 11, 2016 Category: Geriatrics Authors: Gunathilake, R., Oldmeadow, C., McEvoy, M., Inder, K. J., Schofield, P. W., Nair, B. R., Attia, J. Tags: Research Article Source Type: research

Relationships Between Caffeine Intake and Risk for Probable Dementia or Global Cognitive Impairment: The Womens Health Initiative Memory Study
Conclusion: Our findings suggest lower odds of probable dementia or cognitive impairment in older women whose caffeine consumption was above median for this group and are consistent with the existing literature showing an inverse association between caffeine intake and age-related cognitive impairment. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - November 11, 2016 Category: Geriatrics Authors: Driscoll, I., Shumaker, S. A., Snively, B. M., Margolis, K. L., Manson, J. E., Vitolins, M. Z., Rossom, R. C., Espeland, M. A. Tags: Research Article Source Type: research

Caffeine Intake and Dementia Risk--A Health Benefit From One of Lifes Simple Pleasures?
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - November 11, 2016 Category: Geriatrics Authors: Morris, M. C. Tags: Guest Editorial Source Type: research

The Redox-sensitive Induction of the Local Angiotensin System Promotes Both Premature and Replicative Endothelial Senescence: Preventive Effect of a Standardized Crataegus Extract
This study has assessed the possibility that the local angiotensin system promotes endothelial senescence in coronary artery endothelial cells and also the protective effect of the Crataegus extract WS1442, a quantified hawthorn extract. Serial passaging from P1 to P4 (replicative senescence) and treatment of P1 endothelial cells with the eNOS inhibitor L-NAME (premature senescence) promoted acquisition of markers of senescence, enhanced ROS formation, decreased eNOS expression, and upregulation of angiotensin-converting enzyme (ACE) and AT1 receptors. Increased SA-β-gal activity and the upregulation of ACE and AT1R i...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - November 11, 2016 Category: Geriatrics Authors: Khemais-Benkhiat, S., Idris-Khodja, N., Ribeiro, T. P., Silva, G. C., Abbas, M., Kheloufi, M., Lee, J.-O., Toti, F., Auger, C., Schini-Kerth, V. B. Tags: Original Article Source Type: research

Age-related Decline of Abiotic Stress Tolerance in Young Drosophila melanogaster Adults
Stress tolerance generally declines with age as a result of functional senescence. Age-dependent alteration of stress tolerance can also occur in early adult life. In Drosophila melanogaster, evidence of such a decline in young adults has only been reported for thermotolerance. It is not known whether early adult life entails a general stress tolerance reduction and whether the response is peculiar to thermal traits. The present work was designed to investigate whether newly eclosed D melanogaster adults present a high tolerance to a range of biotic and abiotic insults. We found that tolerance to most of the abiotic stress...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - November 11, 2016 Category: Geriatrics Authors: Colinet, H., Chertemps, T., Boulogne, I., Siaussat, D. Tags: Original Article Source Type: research

Cranberry Extract Standardized for Proanthocyanidins Alleviates {beta}-Amyloid Peptide Toxicity by Improving Proteostasis Through HSF-1 in Caenorhabditis elegans Model of Alzheimers Disease
A growing body of evidence suggests that nutraceuticals with prolongevity properties may delay the onset of Alzheimer’s disease (AD). We recently demonstrated that a proanthocyanidins-standardized cranberry extract has properties that prolong life span and promote innate immunity in Caenorhabditis elegans. In this article, we report that supplementation of this cranberry extract delayed Aβ toxicity-triggered body paralysis in the C elegans AD model. Genetic analyses indicated that the cranberry-mediated Aβ toxicity alleviation required heat shock transcription factor (HSF)-1 rather than DAF-16 and SKN-1. Mo...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - November 11, 2016 Category: Geriatrics Authors: Guo, H., Cao, M., Zou, S., Ye, B., Dong, Y. Tags: Original Article Source Type: research

Circulating Concentrations of Growth Differentiation Factor 11 Are Heritable and Correlate With Life Span
This study revealed high heritability of GDF11 levels. Furthermore, our correlative data suggest that GDF11 may serve as a novel predictor of mammalian life span. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - November 11, 2016 Category: Geriatrics Authors: Zhou, Y., Jiang, Z., Harris, E. C., Reeves, J., Chen, X., Pazdro, R. Tags: Brief Report Source Type: research

Increased Protein Stability and Decreased Protein Turnover in the Caenorhabditis elegans Ins/IGF-1 daf-2 Mutant
In Caenorhabditis elegans, cellular proteostasis is likely essential for longevity. Autophagy has been shown to be essential for lifespan extension of daf-2 insulin/IGF mutants. Therefore, it can be hypothesized that daf-2 mutants achieve this phenotype by increasing protein turnover. However, such a mechanism would exert a substantial energy cost. By using classical 35S pulse-chase labeling, we observed that protein synthesis and degradation rates are decreased in young adults of the daf-2 insulin/IGF mutants. Although reduction of protein turnover may be energetically favorable, it may lead to accumulation and aggregatio...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - November 11, 2016 Category: Geriatrics Authors: Depuydt, G., Shanmugam, N., Rasulova, M., Dhondt, I., Braeckman, B. P. Tags: Original Article Source Type: research

Temporal Development of Autonomic Dysfunction in Heart Failure: Effects of Age in an Ovine Rapid-pacing Model
In conclusion, aging is associated with altered autonomic control and β-adrenergic responsiveness of HR, and these are exacerbated with the development of HF. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - November 11, 2016 Category: Geriatrics Authors: Horn, M. A., Bode, E. F., Borland, S. J., Kirkwood, G. J., Briston, S. J., Richards, M. A., Dibb, K. M., Trafford, A. W. Tags: Original Article Source Type: research

Genetic Influence on the Peripheral Blood CD4+ T-cell Differentiation Status in CMV Infection
A latent infection with cytomegalovirus (CMV), a ubiquitous beta herpesvirus, is associated with an accumulation of late-differentiated memory T-cells, often accompanied by a reciprocal reduced frequency of early-differentiated cells (commonly also referred to as "naïve"). However, this impact of CMV on T-cell phenotypes is variable between individuals. Our previous findings in a subgroup of participants in the Leiden familial Longevity Study indicated an important role of genetics. For further testing, we have analyzed middle-aged monozygotic (MZ, n = 42) and dizygotic (DZ, n = 39) twin pairs from the Danish Twin ...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - November 11, 2016 Category: Geriatrics Authors: Goldeck, D., Larsen, L. A., Christiansen, L., Christensen, K., Hamprecht, K., Pawelec, G., Derhovanessian, E. Tags: Original Article Source Type: research

Blood Pressure Trajectory, Gait Speed, and Outcomes: The Health, Aging, and Body Composition Study
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - November 11, 2016 Category: Geriatrics Authors: Odden, M. C., Wu, C., Shlipak, M. G., Psaty, B. M., Katz, R., Applegate, W. B., Harris, T., Newman, A. B., Peralta, C. A., for the Health ABC Study Tags: Erratum Source Type: research