Journals of Gerontology Series A: Biological Sciences and Medical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Characterizing Frailty Status in the Systolic Blood Pressure Intervention Trial
Conclusions: Large clinical trials assessing treatments to reduce cardiovascular disease risk, such as SPRINT, can enroll heterogeneous populations of older adults, including the frail elderly, comparable with general population cohorts. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Authors: Pajewski, N. M., Williamson, J. D., Applegate, W. B., Berlowitz, D. R., Bolin, L. P., Chertow, G. M., Krousel-Wood, M. A., Lopez-Barrera, N., Powell, J. R., Roumie, C. L., Still, C., Sink, K. M., Tang, R., Wright, C. B., Supiano, M. A., for the SPRINT Stu Tags: Research Article Source Type: research

Joint Associations of Dual Sensory Impairment and No-Activity Involvement With 1-Year Mortality in Nursing Homes: Results From the SHELTER Study
Conclusions: DSI is associated with increased mortality at nursing homes when combined with no involvement in activities. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Authors: Yamada, Y., Denkinger, M. D., Onder, G., van der Roest, H. G., Finne-Soveri, H., Bernabei, R., Topinkova, E. Tags: Research Article Source Type: research

Estimating the Years Lived With and Without Age-Related Sensory Impairment
Conclusions: In addition to being highly prevalent, hearing and vision impairment affect older adults for substantial periods of their remaining life. Given their broad ranging impacts on health and well-being, sensory impairments are ideal targets for strategies to compress morbidity in late life. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Authors: Kiely, K. M., Mitchell, P., Gopinath, B., Luszcz, M. A., Jagger, C., Anstey, K. J. Tags: Research Article Source Type: research

What is a Clinically Meaningful Improvement in Leg-Extensor Power for Mobility-limited Older Adults?
Conclusions: This is the first study to establish a clinically meaningful improvement of leg-extensor power (9%–10%) and velocity (6%–7%) in mobility-limited older adults. These findings should be used to aid in the design and interpretation of clinical trials and interventions that target improvements in muscle power in this high-risk population. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Authors: Kirn, D. R., Reid, K. F., Hau, C., Phillips, E. M., Fielding, R. A. Tags: Brief Report Source Type: research

Association Rules Analysis of Comorbidity and Multimorbidity: The Concord Health and Aging in Men Project
Conclusions: Old age is characterized by a complex pattern of multimorbidity and comorbidity. Single disease definitions do not account for the prevalence and complexity of multimorbidity in older people and a new lexicon may be needed to underpin research and health care interventions for older people. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Authors: Held, F. P., Blyth, F., Gnjidic, D., Hirani, V., Naganathan, V., Waite, L. M., Seibel, M. J., Rollo, J., Handelsman, D. J., Cumming, R. G., Le Couteur, D. G. Tags: Research Article Source Type: research

Response to the Letter "Blood Flow Restricted Training in Older Adults: Consider Standardized Methodology for Future Investigations?"
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Authors: Yasuda, T., Nakajima, T. Tags: Letter to the Editor Source Type: research

Blood Flow Restricted Training in Older Adults: Consider Standardized Methodology for Future Investigations?
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Authors: Loenneke, J. P., Abe, T. Tags: Letter to the Editor Source Type: research

Monocyte Phenotype and Polyfunctionality Are Associated With Elevated Soluble Inflammatory Markers, Cytomegalovirus Infection, and Functional and Cognitive Decline in Elderly Adults
Monocytes are mediators of the inflammatory response and include three subsets: classical, intermediate, and nonclassical. Little is known about the phenotypical and functional age-related changes in monocytes and their association with soluble inflammatory biomarkers, cytomegalovirus infection, and functional and mental decline. We assayed the activation ex vivo and the responsiveness to TLR2 and TLR4 agonists in vitro in the three subsets and assessed the intracellular production of IL1-alpha (α), IL1-beta (β), IL-6, IL-8, TNF-α, and IL-10 of elderly adults (median 83 [67–90] years old; n = 20) com...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Authors: de Pablo-Bernal, R. S., Canizares, J., Rosado, I., Galva, M. I., Alvarez-Rios, A. I., Carrillo-Vico, A., Ferrando-Martinez, S., Munoz-Fernandez, M. A., Rafii-El-Idrissi Benhnia, M., Pacheco, Y. M., Ramos, R., Leal, M., Ruiz-Mateos, E. Tags: Original Article Source Type: research

Aerobic Exercise Recovers Disuse-induced Atrophy Through the Stimulus of the LRP130/PGC-1{alpha} Complex in Aged Rats
Physical training has been shown to be important to the control of muscle mass during aging, through the activation of several pathways including, IGF1-AKT and PGC-1α. Also, it was demonstrated that LRP130, a component of the PGC-1α complex, is important for the PGC-1α-dependent transcription of several mitochondrial genes in vivo. To explore the role of physical training during aging, we investigated the effects on muscle recovery after short-term immobilization followed by 3 or 7 days with aerobic or resistance training. Using morphological (myofibrillar adenosine triphosphatase activity, to assess the ...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Authors: Vechetti-Junior, I. J., Bertaglia, R. S., Fernandez, G. J., de Paula, T. G., de Souza, R. W. A., Moraes, L. N., Mareco, E. A., de Freitas, C. E. A., Aguiar, A. F., Carvalho, R. F., Dal-Pai-Silva, M. Tags: Original Article Source Type: research

Coenzyme Q Protects Against Age-Related Alveolar Bone Loss Associated to n-6 Polyunsaturated Fatty Acid Rich-Diets by Modulating Mitochondrial Mechanisms
An age-dependent model of the periodontium was reproduced to evaluate the effect of life-long feeding on a low coenzyme Q10 dosage in n-6, n-3 polyunsaturated fatty acid or monounsaturated fatty acid-based diets on periodontal tissues of young and old rats. Results shown that exacerbated age-related alveolar bone loss previously associated to n-6 polyunsaturated fatty acid diet was attenuated by coenzyme Q10. Gene expression analysis suggests that involved mechanisms might be related to a restored capacity of mitochondria to adapt to aging in gingival cells from rats fed on n-6 polyunsaturated fatty acid. In particular, th...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Authors: Varela-Lopez, A., Bullon, P., Battino, M., Ramirez-Tortosa, M., Ochoa, J. J., Cordero, M. D., Ramirez-Tortosa, C. L., Rubini, C., Zizzi, A., Quiles, J. L. Tags: Original Article Source Type: research

Polymorphisms Falling Within Putative miRNA Target Sites in the 3'UTR Region of SIRT2 and DRD2 Genes Are Correlated With Human Longevity
Many studies have suggested that individual differences in aging phenotypes may be associated to polymorphisms affecting gene regulation. As single-nucleotide polymorphisms (SNPs) in the 3'-untranslated regions (3'UTR) targeted by microRNAs (miRNAs) can alter the strength of miRNA binding (and, consequently, the regulation of target genes), we wondered whether these SNPs (known as miRSNPs) affect the individual chance to become long-lived. Thus, we estimated the effect of miRSNPs falling in the 3'-untranslated regions of 140 aging-related genes on the DNA/miRNA bond. The 24 miRSNPs with the highest difference of binding en...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Authors: Crocco, P., Montesanto, A., Passarino, G., Rose, G. Tags: Original Article Source Type: research

Human Aging Is a Metabolome-related Matter of Gender
A molecular description of the mechanisms by which aging is produced is still very limited. Here, we have determined the plasma metabolite profile by using high-throughput metabolome profiling technologies of 150 healthy humans ranging from 30 to 100 years of age. Using a nontargeted approach, we detected 2,678 metabolite species in plasma, and the multivariate analyses separated perfectly two groups indicating a specific signature for each gender. In addition, there is a set of gender-shared metabolites, which change significantly during aging with a similar tendency. Among the identified molecules, we found vitamin D2-re...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Authors: Jove, M., Mate, I., Naudi, A., Mota-Martorell, N., Portero-Otin, M., De la Fuente, M., Pamplona, R. Tags: Original Article Source Type: research

Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging
We aimed to develop a mouse model of polypharmacy, primarily to establish whether short-term exposure to polypharmacy causes adverse geriatric outcomes. We also investigated whether old age increased susceptibility to any adverse geriatric outcomes of polypharmacy. Young (n = 10) and old (n = 21) male C57BL/6 mice were administered control diet or polypharmacy diet containing therapeutic doses of five commonly used medicines (simvastatin, metoprolol, omeprazole, acetaminophen, and citalopram). Mice were assessed before and after the 2- to 4-week intervention. Over the intervention period, we observed no mortality and no ch...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Authors: Huizer-Pajkos, A., Kane, A. E., Howlett, S. E., Mach, J., Mitchell, S. J., de Cabo, R., Le Couteur, D. G., Hilmer, S. N. Tags: Original Article Source Type: research

The Polypharmacy Mouse Model: Novel Findings and New Opportunities
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Authors: Johnell, K. Tags: Editorial Source Type: research

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(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research