Journals of Gerontology Series A: Biological Sciences and Medical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Assessing Fatigability in the Lab and in Daily Life in Older Adults With Osteoarthritis Using Perceived, Performance, and Ecological Measures
Conclusion: Lab-based fatigability measures are related to physical capacity measured both in the lab and daily life. Lab-based fatigability measures provide important information regarding daily life fatigability useful for future intervention development. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Murphy, S. L., Kratz, A. L., Schepens Niemiec, S. L. Tags: Research Article Source Type: research

The Survival of Spouses Marrying Into Longevity-Enriched Families
Conclusion: The mortality for ages 20–69 years of spouses marrying into longevity-enriched families is substantially lower than the mortality in the background population, although long-lived siblings participation bias may have contributed to the difference. This finding has implications for the use of spouses as controls in healthy aging and longevity studies, as environmental and/or genetic overmatching may occur. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Pedersen, J. K., Elo, I. T., Schupf, N., Perls, T. T., Stallard, E., Yashin, A. I., Christensen, K. Tags: Research Article Source Type: research

The Severity of Acute Illness and Functional Trajectories in Hospitalized Older Medical Patients
Conclusions: The severity of illnesses was strongly associated with adverse functional outcomes around hospitalization, but frailty, intended as functional vulnerability to the acute disease before hospitalization, was a stronger predictor of HAD than illness severity and age. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Fimognari, F. L., Pierantozzi, A., De Alfieri, W., Salani, B., Zuccaro, S. M., Arone, A., Palleschi, G., Palleschi, L. Tags: Research Article Source Type: research

Sarcopenia and Health Care Utilization in Older Women
Conclusion: Estimated effects of sarcopenia on health care utilization were negligible. However, slowness was associated with greater health care utilization. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Cawthon, P. M., Lui, L.-Y., McCulloch, C. E., Cauley, J. A., Paudel, M. L., Taylor, B., Schousboe, J. T., Ensrud, K. E. Tags: Research Article Source Type: research

Effects of Age and Functional Status on the Relationship of Systolic Blood Pressure With Mortality in Mid and Late Life: The ARIC Study
Conclusions. Compared with younger and well-functioning persons, the additional contribution of blood pressure to mortality is much lower with older age and impaired function, particularly if both are present. Functional status and age could potentially inform optimal blood pressure targets. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Windham, B. G., Griswold, M. E., Lirette, S., Kucharska-Newton, A., Foraker, R. E., Rosamond, W., Coresh, J., Kritchevsky, S., Mosley, T. H. Tags: Research Article Source Type: research

Effects of Mobility and Cognition on Hospitalization and Inpatient Days in Women in Late Life
Conclusions: Among women late in life, mobility limitations and cognitive deficits were each independent predictors of higher inpatient health care utilization even after considering each other and conventional predictors. Additive effects of reduced mobility and poorer cognition may be important to consider in medical decision making and health care policy planning for the growing population of adults aged ≥85 years. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Ensrud, K. E., Lui, L.-Y., Paudel, M. L., Schousboe, J. T., Kats, A. M., Cauley, J. A., McCulloch, C. E., Yaffe, K., Cawthon, P. M., Hillier, T. A., Taylor, B. C., for the Study of Osteoporotic Fractures (SOF) Tags: Research Article Source Type: research

Simple Test of Manual Dexterity Can Help to Identify Persons at High Risk for Neurodegenerative Diseases in the Community
Conclusions: A rapid, nonlaboratory test of manual dexterity may help to identify persons at high risk for neurodegenerative diseases. This highlights the importance of motor function in the preclinical phase of both dementia and parkinsonism and may aid in selecting individuals for refined screening and neuroprotective trials. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Darweesh, S. K. L., Wolters, F. J., Hofman, A., Stricker, B. H., Koudstaal, P. J., Ikram, M. A. Tags: Special Issue: Utility of Brief Cognitive and Physical Assessments in Clinical Care: Special Article Source Type: research

Measuring Frailty Can Help Emergency Departments Identify Independent Seniors at Risk of Functional Decline After Minor Injuries
Conclusion. Measuring frailty in community-dwelling seniors with minor injuries in EDs may enhance current risk screening for functional decline. However, before implementation in usual care, feasibility issues such as inter-rater reliability and acceptability of frailty tools in the EDs have to be addressed. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Sirois, M.-J., Griffith, L., Perry, J., Daoust, R., Veillette, N., Lee, J., Pelletier, M., Wilding, L., Emond, M. Tags: Research Article Source Type: research

Cognitive Status at Hospital Admission: Postoperative Trajectory of Functional Recovery for Hip Fracture
Conclusions. Patients with cognitive impairment who fracture their hips recover more slowly and achieve less functional recovery. Recovery is not uniform nor is it linear over the initial 6 months. The diversity of patient needs should be recognized postoperatively so that long-term recovery is optimized. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Jones, C. A., Jhangri, G. S., Feeny, D. H., Beaupre, L. A. Tags: Research Article Source Type: research

Utility of Brief Cognitive and Physical Assessments in Clinical Care
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Studenski, S. Tags: Editorial Source Type: research

Multiple Metazoan Life-span Interventions Exhibit a Sex-specific Strehler-Mildvan Inverse Relationship Between Initial Mortality Rate and Age-dependent Mortality Rate Acceleration
The Gompertz equation describes survival in terms of initial mortality rate (parameter a), indicative of health, and age-dependent acceleration in mortality rate (parameter b), indicative of aging. Gompertz parameters were analyzed for several published studies. In Drosophila females, mating increases egg production and decreases median life span, consistent with a trade-off between reproduction and longevity. Mating increased parameter a, causing decreased median life span, whereas time parameter b was decreased. The inverse correlation between parameters indicates the Strehler–Mildvan (S-M) relationship, where loss...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Shen, J., Landis, G. N., Tower, J. Tags: Original Article Source Type: research

Four Cases of Spontaneous Neoplasia in the Naked Mole-Rat (Heterocephalus glaber), A Putative Cancer-Resistant Species
The naked mole-rat (Heterocephalus glaber) is widely acclaimed to be cancer-resistant and of considerable research interest based on a paucity of reports of neoplasia in this species. We have, however, encountered four spontaneous cases of neoplasia and one presumptive case of neoplasia through routine necropsy and biopsy of individuals in a zoo collection of nonhybrid naked mole-rats bred from a single pair. One case each of metastasizing hepatocellular carcinoma, nephroblastoma (Wilms’ tumor), and multicentric lymphosarcoma, as well as presumptive esophageal adenocarcinoma (Barrett’s esophagus-like) was ident...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Taylor, K. R., Milone, N. A., Rodriguez, C. E. Tags: Brief Report Source Type: research

A Stress-Resistant Lipidomic Signature Confers Extreme Longevity to Humans
Plasma lipidomic profile is species specific and an optimized feature associated with animal longevity. In the present work, the use of mass spectrometry technologies allowed us to determine the plasma lipidomic profile and the fatty acid pattern of healthy humans with exceptional longevity. Here, we show that it is possible to define a lipidomic signature only using 20 lipid species to discriminate adult, aged and centenarian subjects obtaining an almost perfect accuracy (90%–100%). Furthermore, we propose specific lipid species belonging to ceramides, widely involved in cell-stress response, as biomarkers of extrem...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Jove, M., Naudi, A., Gambini, J., Borras, C., Cabre, R., Portero-Otin, M., Vina, J., Pamplona, R. Tags: Original Article Source Type: research

CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging
The major histocompatibility complex I (MHCI) pathway, which canonically functions in innate immune viral antigen presentation and detection, is functionally pleiotropic in the central nervous system (CNS). Alternative roles include developmental synapse pruning, regulation of synaptic plasticity, and inhibition of neuronal insulin signaling; all processes altered during brain aging. Upregulation of MHCI components with aging has been reported; however, no systematic examination of MHCI cellular localization, expression, and regulation across CNS regions, life span, and sexes has been reported. In the mouse, MHCI is expres...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Mangold, C. A., Masser, D. R., Stanford, D. R., Bixler, G. V., Pisupati, A., Giles, C. B., Wren, J. D., Ford, M. M., Sonntag, W. E., Freeman, W. M. Tags: Original Article Source Type: research

17{alpha}-Estradiol: A Novel Therapeutic Intervention to Target Age-related Chronic Inflammation
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Gonzalez-Freire, M., Diaz-Ruiz, A., de Cabo, R. Tags: Guest Editorial Source Type: research