Obesity and Structural Brain Integrity in Older Women: The Womens Health Initiative Magnetic Resonance Imaging Study

Conclusions: Obesity in this cohort is associated with less brain atrophy and lower ischemic lesion loads. The findings are consistent with our previous report of worse cognitive performance in association with weight loss (probably not due to frailty) in this cohort and in line with the idea of the "obesity paradox" as differences in dementia risk vary across time, whereby midlife obesity seems to be a predictor of dementia, whereas weight loss seems to be a better predictor at older ages.
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - Category: Geriatrics Authors: Tags: Research Article Source Type: research