Possible Hepatotoxicity Associated With Daptomycin: A Case Report and Literature Review
Conclusion
Although hepatic abnormalities caused by daptomycin are rare, a handful of cases with daptomycin-induced liver injury have been reported in the literature. Of note, in most cases, patients on daptomycin therapy developed liver damage with elevations in CK levels. Our case report suggests possible severe liver injury associated with high-dose and long-term daptomycin treatment in the absence of rhabdomyolysis. Future research is warranted to further investigate the relationship between daptomycin use and liver injury, yet it is reasonable to monitor liver function tests at baseline and weekly thereafter along wit...
Source: Journal of Pharmacy Practice - May 10, 2016 Category: Drugs & Pharmacology Authors: Mo, Y., Nehring, F., Jung, A. H., Housman, S. T. Tags: Adverse Drug Events Source Type: research
Hypothermia Associated With Thioridazine Use in an Intellectually Disabled Patient
Conclusion:
This case indicates a possible correlation between hypothermia and the use of phenothiazine antipsychotics such as thioridazine. Appropriate measures, including early detection and identification of possible causative agents, should be taken to prevent and treat this adverse event in patients taking these medications, specifically in patients with the inability to participate in self-care. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - May 10, 2016 Category: Drugs & Pharmacology Authors: Goodbar, N. H., Foushee, J. A., Nash, K., Connolly, L. A., Webster, L. M. Tags: Adverse Drug Events Source Type: research
Developments in Oral Antiplatelet Agents for the Treatment of Acute Coronary Syndromes: Clopidogrel, Prasugrel, and Ticagrelor
A review of the literature was conducted for clinical trials evaluating the antiplatelet P2Y12 receptor antagonists, clopidogrel, prasugrel, and ticagrelor, as well as the guidelines for the management of acute coronary syndrome (ACS) or myocardial infarction. Clinical guidelines recommend that patients with ACS be treated with dual oral antiplatelet therapy of aspirin plus clopidogrel, prasugrel, or ticagrelor. The selection of an appropriate antiplatelet agent depends on the treatment approach and a patient’s bleeding risk and clinical history. With respect to antiplatelet activity, prasugrel and ticagrelor demonst...
Source: Journal of Pharmacy Practice - May 10, 2016 Category: Drugs & Pharmacology Authors: Roffman, D. S. Tags: Review Articles Source Type: research
Establishing Edoxabans Role in Anticoagulation
Conclusion
Based on the 3 clinical trials, edoxaban appears to be a safe and effective factor Xa inhibitor in patients with a creatinine clearance of <95 mL/min. It will serve as an alternative anticoagulant for those with a preference for once-daily dosing and/or taking medications that interact with the CYP450 system. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - May 10, 2016 Category: Drugs & Pharmacology Authors: Guirguis, E., Brown, D., Grace, Y., Patel, D., Henningfield, S. Tags: Review Articles Source Type: research
The Redesign of a Community Pharmacy Internship Program
Conclusions:
The restructured internship program provided pharmacy students with a 10-week program that exposed them to many aspects of community pharmacy practice. The program needs future refinement and assessment measures to verify interns improve skills throughout the program. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - May 10, 2016 Category: Drugs & Pharmacology Authors: Pattin, A. J., Kelling, S. E., Szyskowski, J., Izor, M. L., Findley, S. Tags: Research Articles Source Type: research
Chemoprophylaxis Use and Risk of Venous Thromboembolism and Death in Adult Patients following Orthotopic Liver Transplantation
Conclusion:
Use of chemoprophylaxis and increasing amounts of blood products following orthotopic liver transplant was associated with increased mortality. A significant positive association was observed between blood product administration and VTE, while chemoprophylaxis use was not significantly associated with VTE. Larger prospective studies are necessary to further examine the significance of this finding. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - May 10, 2016 Category: Drugs & Pharmacology Authors: Alexander, B. R., Antigua, A. D., Rosenberg, A. F., Caruso, L. J., Voils, S. A., LeClaire, A. C. Tags: Research Articles Source Type: research
Treatment of Acute Hepatic Encephalopathy: Comparing the Effects of Adding Rifaximin to Lactulose on Patient Outcomes
Conclusion:
Addition of rifaximin to lactulose for treatment of acute HE did not reduce hospital LOS; however, it did result in lower readmission rates for HE at 180 days. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - May 10, 2016 Category: Drugs & Pharmacology Authors: Courson, A., Jones, G. M., Twilla, J. D. Tags: Research Articles Source Type: research
Evaluation of the Feasibility and Utility of a Pharmacist-Centered Collaborative Drug Therapy Management Program for Oncology-Based Symptom Management
Collaborative drug therapy management (CDTM) is a practice agreement between a pharmacist and a physician, which allows the pharmacist to assume responsibility of drug therapy management. There has been limited documentation of CDTM practices in the oncology setting. Therefore, a CDTM program in the gynecology oncology clinic at Roswell Park Cancer Institute (RPCI) was initiated to establish the feasibility and utility of CDTM and its effects on patient care and physician satisfaction. Primarily, 3 symptoms were managed by the CDTM pharmacists, namely chemotherapy-induced nausea and vomiting (CINV), chemotherapy-induced pe...
Source: Journal of Pharmacy Practice - May 10, 2016 Category: Drugs & Pharmacology Authors: Hansen, E. A., Pietkiewicz, J. M., Blum, B. L. Tags: Research Articles Source Type: research
Satisfaction With Medication Therapy Management Services at a University Ambulatory Care Clinic
A survey was issued to patients enrolled in the Medication Therapy Management Clinic (MTMC) at University of Illinois Hospital and Health Sciences (June 2011-January 2012) in order to assess satisfaction with pharmacy services provided by pharmacists. A 23-item survey was offered to 65 patients in the MTMC program before or after clinic visits. Since there is a paucity of data indicating the level of satisfaction with MTM services provided by pharmacists, this survey may contribute to the process of building a greater collaboration between the pharmacist and patient. Sixty-two of 65 patients completed the survey; satisfact...
Source: Journal of Pharmacy Practice - May 10, 2016 Category: Drugs & Pharmacology Authors: Kim, S., Martin, M. T., Pierce, A. L., Zueger, P. Tags: Research Articles Source Type: research
Concordance of Pharmacist Assessment of Medication Nonadherence With a Self-Report Medication Adherence Scale
Conclusion:
A combination of methods including self-report and pharmacist assessment may provide the greatest insight into adherence. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - May 10, 2016 Category: Drugs & Pharmacology Authors: Kelly, M. S., Moczygemba, L. R., Gatewood, S. S. Tags: Research Articles Source Type: research
Assessment of Antimicrobial Stewardship Activities in a Large Metropolitan Area
Conclusion:
This is the first major survey of ASP in a major metropolitan area. The stewardship effort in the city of Houston is encouraging; we expect the number of stewardship programs in all facilities will continue to rise as focus on antimicrobial resistance grows. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - May 10, 2016 Category: Drugs & Pharmacology Authors: Jacobs, D. M., Kuper, K., Septimus, E., Arafat, R., Garey, K. W. Tags: Research Articles Source Type: research
Presidential Address: Find Your Inner Bernie...
(Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - March 17, 2016 Category: Drugs & Pharmacology Authors: Seyse, S. Tags: New York State Council of Health-system Pharmacists Section Source Type: research
Pretreatment With Caffeine Citrate to Increase Seizure Duration During Electroconvulsive Therapy: A Case Series
Conclusion:
It was determined that, much like caffeine and sodium benzoate, caffeine citrate does increase the seizure duration. However, this response did vary due to many reasons including small sample size, concomitant medications, duration of illness, and number of ECTs they received in the past and how long ago they received the last ECT. Further research is required to elucidate the effect of these variables on seizure duration. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - March 17, 2016 Category: Drugs & Pharmacology Authors: Pinkhasov, A., Biglow, M., Chandra, S., Pica, T. Tags: Case Report Source Type: research
A Case of Severe, Prolonged, Refractory Hypophosphatemia After Zoledronic Acid Administration
We describe a case of severe, refractory hypophosphatemia in a patient who received ZA for hypercalcemia of malignancy (HCM). Little data are available that describe the incidence or degree of severity of hypophosphatemia that can occur following ZA administration. In addition, no formal recommendations exist to guide monitoring for or management of electrolyte derangements in the setting of bisphosphonate use. Our patient required daily, high-dose phosphorus replacement beginning day 4 following ZA administration. The average daily dose of phosphorus, including both intravenous and enteral administration, was highest in t...
Source: Journal of Pharmacy Practice - March 17, 2016 Category: Drugs & Pharmacology Authors: Clark, S. L., Nystrom, E. M. Tags: Adverse Drug Event Source Type: research
Dapagliflozin: A Sodium Glucose Cotransporter 2 Inhibitor for the Treatment of Diabetes Mellitus
Conclusion:
Dapagliflozin is effective for the treatment of type 2 diabetes. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - March 17, 2016 Category: Drugs & Pharmacology Authors: Davis, P. N., Ndefo, U. A., Oliver, A. Tags: Review Articles Source Type: research
