Introduction: Drug-Induced Diseases II
(Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - November 3, 2014 Category: Drugs & Pharmacology Authors: Saltiel, M. Tags: Drug-Induced Diseases Source Type: research
President's Message: When They Ask Me Why . . .
(Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - September 23, 2014 Category: Drugs & Pharmacology Authors: Shlom, E. A. Tags: New York State Council of Health-system Pharmacists Section Source Type: research
Impact of an Online Educational Program on Pharmacy Students' Knowledge of Folic Acid and Neural Tube Defects
Conclusion: Online videos are tools to teach pharmacy students key information regarding folic acid and NTD; however, material should be reinforced in experiential education as well. Counseling women of childbearing potential about folic acid fulfills an important public health need. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - September 23, 2014 Category: Drugs & Pharmacology Authors: Bykhovsky, M., Meier, M. F. K., Mager, N. A. D. Tags: Pharmacy Education Source Type: research
Antipsychotic Use and the Risk of Rhabdomyolysis
Rhabdomyolysis is not a well-understood adverse effect of antipsychotic use. Proposed mechanisms suggest involvement of serotoninergic and/or dopaminergic blockade. The purpose of this study was to describe the relationship between antipsychotic use and rhabdomyolysis. Patients admitted with rhabdomyolysis and taking an antipsychotic from January 2009 to October 2011 were included. Background demographics, laboratory data, medical and physical history, concomitant medications, and hospital course data were collected. Of the 673 cases admitted with rhabdomyolysis, 71 (10.5%) were on an antipsychotic. This is significantly g...
Source: Journal of Pharmacy Practice - September 23, 2014 Category: Drugs & Pharmacology Authors: Packard, K., Price, P., Hanson, A. Tags: Adverse Drug Event Source Type: research
Azithromycin and the Risk of Cardiovascular Complications
The purpose of this review was to evaluate the literature to assess the incidence and true clinical relevance of recent Food and Drug Administration warnings regarding QT prolongation with azithromycin, given its widespread use, with over 40 million US outpatient prescriptions written in 2011. A literature search of MEDLINE (1946 to May 2013) and International Pharmaceutical Abstracts (1970 to May 2013) was conducted using the terms azithromycin, QT prolongation, torsades de pointes, arrhythmia, and cardiovascular death. A bibliographic search was also performed. Several relevant studies and case reports were identified an...
Source: Journal of Pharmacy Practice - September 23, 2014 Category: Drugs & Pharmacology Authors: Maisch, N. M., Kochupurackal, J. G., Sin, J. Tags: Review Articles Source Type: research
Safety and Efficacy of Corticosteroid Use in Neurologic Trauma
Neurologic trauma, which consists of acute spinal cord injury and traumatic brain injury, is a leading cause of death and disability. In recent years, there have been improvements in the early recognition and prompt resuscitation of patients with neurologic trauma. However, there remain few pharmacologic treatments to reduce its secondary complications. Corticosteroids have been used in patients with neurologic trauma for more than 5 decades. Traditionally, their use has been to improve motor and sensory recovery. However, recently their utility to prevent and manage trauma-related pneumonia has been investigated. Given th...
Source: Journal of Pharmacy Practice - September 23, 2014 Category: Drugs & Pharmacology Authors: Han, Z., Lat, I., Pollard, S. R. Tags: Review Articles Source Type: research
A Practical Guide to Concentrated Insulin for Pharmacists
Conclusion: Concentrated insulin works in the same mechanism as U-100 insulin formulations for treating type 1 and type 2 diabetes. Pharmacists are knowledgeable about managing the disease and can identify patients who will benefit with treatment of concentrated insulin. They can provide recommendations to prevent and resolve situations, such as dosing errors, which arise in patients on concentrated insulin and can educate patients and health care professionals on dosing conversions and titration. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - September 23, 2014 Category: Drugs & Pharmacology Authors: Andres, J., Clements, J. N. Tags: Review Articles Source Type: research
Assessing the Potential of E-mail for Communicating Drug Therapy Recommendations to Physicians in Patients With Heart Failure and Ventricular-Assist Devices
Conclusion: Clinical pharmacists with well-established physician relationships can effectively implement timely drug therapy recommendations using e-mail communications in patients with advanced HF or VADs. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - September 23, 2014 Category: Drugs & Pharmacology Authors: Lekura, J., Tita, C., Lanfear, D. E., Williams, C. T., Jennings, D. L. Tags: Research Articles Source Type: research
Safety of Compounded Calcium Chloride Admixtures for Peripheral Intravenous Administration in the Setting of a Calcium Gluconate Shortage
The objective of this analysis is to evaluate the peripheral infusion site safety of compounded IV calcium chloride admixtures in adult inpatients. A total of 222 patients, encompassing 224 inpatient admissions, from April to June 2011 were retrospectively reviewed. Sterile preparations of calcium chloride in 5% dextrose (600 mg/250 mL and 300 mg/100 mL) were used during the study time period. Adverse infusion site reactions were assessed using an institutional infiltration and phlebitis grading system. A total of 333 doses were administered peripherally. In all, 4 (1.8%) patients experienced a moderate to severe infusion ...
Source: Journal of Pharmacy Practice - September 23, 2014 Category: Drugs & Pharmacology Authors: Anger, K. E., Belisle, C., Colwell, M. B., Dannemiller, R., Alawadhi, B., Wilkocki, A., Szumita, P. M. Tags: Research Articles Source Type: research
Patient Case: Impact of Smoking Cessation on International Normalized Ratio
Conclusion: This case exemplifies how certain lifestyle factors, such as smoking, can alter the pharmacokinetics of patients on chronic warfarin therapy. This is the first case to demonstrate a greater than 30% reduction in the weekly warfarin dose following smoking cessation. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - September 23, 2014 Category: Drugs & Pharmacology Authors: Jordan, S. D., Stone, M. D., Alexander, E., Haley, J., McKee, A. Tags: Case Report Source Type: research
Response to Letter to the Editor: A Practical Guide to Concentrated Insulin for Pharmacists
(Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - September 23, 2014 Category: Drugs & Pharmacology Authors: Clements, J., Andres, J. Tags: Letters to the Editor Source Type: research
Letter to the Editor: A Practical Guide to Concentrated Insulin for Pharmacists
(Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - September 23, 2014 Category: Drugs & Pharmacology Authors: Brusko, C. S., Rees, T. M., Johnson, J. L., Jackson, J. A. Tags: Letters to the Editor Source Type: research
Angioedema Related to Angiotensin Inhibitors
Angiotensin inhibitors have been extensively evaluated in clinical trials and have demonstrated significant reductions in morbidity and mortality following myocardial infarction and stroke, as well as in patients with heart failure or who are at risk of cardiovascular disease. Further, both angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are frequently prescribed for the treatment of hypertension and to preserve renal function in patients with diabetes mellitus and chronic kidney disease. Angioedema is a known, but rare, adverse effect of ACEIs and ARBs. Therefore, it is important ...
Source: Journal of Pharmacy Practice - September 23, 2014 Category: Drugs & Pharmacology Authors: Knecht, S. E., Dunn, S. P., Macaulay, T. E. Tags: Drug-Induced Diseases Source Type: research
Growth Factor Use in Medication-Induced Hematologic Toxicity
Myelosuppression is a dose-limiting adverse effect with antineoplastic therapy and nonchemotherapy medications. Clinicians have data and guidelines to provide direction for the management of neutropenia and thrombocytopenia in patients with malignancies. Clinical situations outside oncology extrapolate these data along with limited data sets for those patients who demonstrate myelosuppressive effects from medications that are not traditionally considered cytotoxic. Pharmacological treatments can be used to help ameliorate the myelosuppressive toxicities. Recombinant technology has provided growth factors to counteract or l...
Source: Journal of Pharmacy Practice - September 23, 2014 Category: Drugs & Pharmacology Authors: Miller, R. C., Steinbach, A. Tags: Drug-Induced Diseases Source Type: research
Nonchemotherapy Drug-Induced Neutropenia and Agranulocytosis: Could Medications be the Culprit?
Drug-induced agranulocytosis is a severe complication that has been implicated with most classes of medications. Medications such as clozapine, trimethoprim-sulfamethoxazole and methimazole have been more commonly associated with agranulocytosis than other agents. Although the pathogenesis isn't fully elucidated, it appears to be two-fold with a direct toxicity to the myeloid cell line and immune-mediated destruction. Patients may be asymptomatic at the time neutropenia is discovered or may present with more severe complications such as sepsis. In approximately 5% of cases drug-induced agranulocytosis may be fatal. Managem...
Source: Journal of Pharmacy Practice - September 23, 2014 Category: Drugs & Pharmacology Authors: Pick, A. M., Nystrom, K. K. Tags: Drug-Induced Diseases Source Type: research
