Providing Medication Therapy Management for Smoking Cessation Patients
Nearly 50 years ago, the Surgeon General of the US Public Health Service released the first report of the Surgeon General’s Advisory Committee on Smoking and Health. The report concluded that cigarette smoking caused lung and laryngeal cancer as well as bronchitis. Today, smoking is one of the leading preventable causes of deaths in the United States. Research has shown that it potentially causes more deaths than human immunodeficiency virus, illegal drug use, alcohol use, motor vehicle injuries, and firearm-related incidents. Health care providers play a critical role in guiding and directing patients to quit smokin...
Source: Journal of Pharmacy Practice - February 24, 2015 Category: Drugs & Pharmacology Authors: Smalls, T. D., Broughton, A. D., Hylick, E. V., Woodard, T. J. Tags: Medication Therapy Management Source Type: research

Psychiatric Services: A Platform for MTM
Deinstitutionalization in the 1960s shifted the care of the mentally ill from state-funded institutions to community settings. Unfortunately, funding to support the treatment needs of this population has continued to be minimized, and countless individuals have not received much needed care. This has resulted in a large increase in mentally ill patients surfacing in jails, homeless shelters, and emergency departments. Subsequently, the federal government has begun to prioritize funding to address the mental health needs of our communities. Pharmacists are in a unique position to influence treatment outcomes for patients wi...
Source: Journal of Pharmacy Practice - February 24, 2015 Category: Drugs & Pharmacology Authors: Lynum, K. S. B., Hill, A. M. Tags: Medication Therapy Management Source Type: research

Role of Medication Therapy Management in Preexposure Prophylaxis Therapy for HIV Prevention
Patient medication adherence is a long-standing problem and is one that raises serious issues for patient health, public health, and health care quality. Medication nonadherence costs the US economy an estimated US$290 billion in avoidable medical spending every year. One of the most costly health conditions is HIV disease, which continues to be a serious health issue for parts of the world. About 34 million people are living with HIV around the world. With the emerging preventative treatment against HIV, known as preexposure prophylaxis (PrEP), come concerns surrounding the potential impact of nonadherence to this newly a...
Source: Journal of Pharmacy Practice - February 24, 2015 Category: Drugs & Pharmacology Authors: Ferrell, K. W., Woodard, L. M., Woodard, T. J. Tags: Medication Therapy Management Source Type: research

Preparing to Provide MTM Services
Medication Therapy Management (MTM) has been a way for pharmacist to enhance their position as an integral member of the health care team as the need for improved clinical and economic outcomes in relation to the US health care system became apparent. MTM Certificate training programs are provided by numerous organizations. Collaboration Practice Agreements (CPA) are gaining significance as the role of the pharmacist is expanding in the care of patients as part of a multidisciplinary health care team. One major hurdle that many pharmacists are faced with is receiving reimbursement for the services provided. The Medicare Mo...
Source: Journal of Pharmacy Practice - February 24, 2015 Category: Drugs & Pharmacology Authors: Glenn, Z. M., Mahdavian, S. L., Woodard, T. J. Tags: Medication Therapy Management Source Type: research

Introduction
(Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - February 24, 2015 Category: Drugs & Pharmacology Authors: Woodard, T. J. Tags: Medication Therapy Management Source Type: research

President's Message: Life-Long Learning in Pharmacy: From CE to CPD
(Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - November 3, 2014 Category: Drugs & Pharmacology Authors: Shlom, E. A. Tags: New York State Council of Health-system Pharmacists Section Source Type: research

Aripiprazole-Associated Hiccups: A Case and Closer Look at the Association Between Hiccups and Antipsychotics
Discussion: The exact etiology of hiccups is unknown but likely involves dopamine and/or -butyric acid. Highlighting the uncertainty related to drug-induced hiccups is the fact that multiple antipsychotics have been reported to not only induce hiccups but also to alleviate them. As the development of persistent hiccups may result in extensive medical workup, clinicians should be aware of drug-associated causes including aripiprazole. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - November 3, 2014 Category: Drugs & Pharmacology Authors: Silverman, M. A., Leung, J. G., Schak, K. M. Tags: Adverse Drug Event Source Type: research

Ketamine: An Update on Its Abuse
Ketamine is a dissociative anesthetic and substance of abuse. Numerous effects can result from the abuse of ketamine. Death from acute direct toxicity is rare. Ketamine can alter numerous functions in the brain including color perception, memory, attention, cognition, reaction time, and sense of time and can produce psychological addiction. Chronic ketamine abuse can produce toxicity to the gastrointestinal and urinary tract. Gastrointestinal changes include epigastric pain, hepatic dysfunction, and impaired gallbladder activity. The most common urological condition from ketamine is cystitis but renal failure has been repo...
Source: Journal of Pharmacy Practice - November 3, 2014 Category: Drugs & Pharmacology Authors: Bokor, G., Anderson, P. D. Tags: Review Article Source Type: research

Pharmacist Testers in Multidisciplinary Health care Team Expand HIV Point-of-Care Testing Program
We describe the expansion of an HIV point-of-care testing (POCT) program within a health care system utilizing pharmacists as testers. The testing program’s expansion is detailed and its impact assessed. The POCT program was evaluated by comparing the number of traditional HIV venipuncture tests to the number of POCTs performed across the health system as well as comparing the number of POCTs performed by clinical pharmacists to the number of tests at other POCT locations. Although pharmacists’ contributions to HIV prevention are well documented, pharmacists’ involvement in HIV testing initiatives is stil...
Source: Journal of Pharmacy Practice - November 3, 2014 Category: Drugs & Pharmacology Authors: Sherman, E. M., Elrod, S., Allen, D., Eckardt, P. Tags: Research Article Source Type: research

Aminoglycoside-Induced Nephrotoxicity
Aminoglycosides are among the oldest antibiotics available to treat serious infections caused by primarily, Gram-negative bacteria. The most commonly utilized parenteral agents in this class include gentamicin, tobramycin and amikacin. Aminoglycosides are concentration-dependent, bactericidal agents that undergo active transport into the cell where they inhibit protein synthesis on the 30S subunit of the bacterial ribosome. As the use of aminoglycosides became more widespread, the toxic effects of these agents, most notably ototoxicity and nephrotoxicity, became more apparent. When other, safer, antimicrobial agents became...
Source: Journal of Pharmacy Practice - November 3, 2014 Category: Drugs & Pharmacology Authors: Wargo, K. A., Edwards, J. D. Tags: Drug-Induced Diseases Source Type: research

Drug-Induced Hepatotoxicity of Select Herbal Therapies
The use of herbal botanicals and dietary supplements to treat and alleviate disease symptoms has increased over the past decades, and as a result, more research has been done to study the potential damaging effects of herbal products on the liver and other organs. Although reporting rates vary, cases have been published describing liver damage following herbal therapy. Studies have proposed multiple mechanisms of injury for these herbal preparations, and several potential risk factors have been identified including age, gender, polypharmacy, alcohol consumption, and genetic variability. Ingredients and other constituents o...
Source: Journal of Pharmacy Practice - November 3, 2014 Category: Drugs & Pharmacology Authors: Korth, C. Tags: Drug-Induced Diseases Source Type: research

Aminoglycoside-Induced Nephrotoxicity--A Focus on Monitoring: A review of Literature
The use of aminoglycoside (AG) antibiotics has declined over the past 15 years primarily due to comparable potency of other antimicrobials and the nephrotoxicity potential of AG drugs. However, resurgence in the use of AG antimicrobials is occurring due to multidrug-resistant gram-negative nosocomial infections. Multidrug-resistant Pseudomonas and Acinetobacter isolates as well as extended-spectrum beta-lactamase–producing Enterobacteriaceae continue to force clinicians to consider AG therapy for nosocomial infections in hospitalized patients and enterococcal endocarditis. Additionally, AGs are still indicated in the...
Source: Journal of Pharmacy Practice - November 3, 2014 Category: Drugs & Pharmacology Authors: Destache, C. J. Tags: Drug-Induced Diseases Source Type: research

Colistin- and Polymyxin-Induced Nephrotoxicity: Focus on Literature Utilizing the RIFLE Classification Scheme of Acute Kidney Injury
With the reintroduction of colistimethate and polymyxin B into clinical practice, a review of their individual and comparative nephrotoxicity attributes as reported in contemporary literature was undertaken. Given variability in definitions used for acute kidney injury, a particular focus was placed on studies utilizing the Risk-Injury-Failure-Loss-End Stage Kidney Disease (RIFLE) criteria of assessment to provide for standardized comparison. Primary risk factors examined included the influence of dosing and the receipt of concomitant nephrotoxins. The typical severity and time course of renal injury that develops were als...
Source: Journal of Pharmacy Practice - November 3, 2014 Category: Drugs & Pharmacology Authors: Pike, M., Saltiel, E. Tags: Drug-Induced Diseases Source Type: research

Vancomycin Nephrotoxicity: A Review
This article is intended to serve as a practical review of vancomycin-associated nephrotoxicity, including historical context, risk factors, and common methods to evaluate and define renal dysfunction. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - November 3, 2014 Category: Drugs & Pharmacology Authors: Mergenhagen, K. A., Borton, A. R. Tags: Drug-Induced Diseases Source Type: research

Beta-Lactam Hypersensitivity and Cross-Reactivity
Penicillin is the most frequently reported cause of drug allergy, and cross-reactivity of penicillins with other beta-lactam antibiotics is an area of debate. This review evaluates the available data on immunoglobulin E-mediated penicillin hypersensitivity and cross-reactivity with cephalosporin, carbapenem, and monobactam antibiotics. A MEDLINE search was conducted from 1950 to October 2013, and selected references from review articles were also evaluated. There is a wide variety in reported incidences of cross-reactivity between penicillins and cephalosporins or carbapenems, with early retrospective studies suggesting up...
Source: Journal of Pharmacy Practice - November 3, 2014 Category: Drugs & Pharmacology Authors: Terico, A. T., Gallagher, J. C. Tags: Drug-Induced Diseases Source Type: research