Antineoplastic Agents and the Associated Myelosuppressive Effects: A Review
Bone marrow is a complex organ responsible for the regulation of hematopoietic cell distribution throughout the human body. Patients receiving antineoplastic agents as a therapeutic intervention for hematologic malignancy often experience varying degrees of myelotoxicity. Antineoplastic agents cause hypocellularity in marrow resulting in a reduction in hematopoietic tissue activity and a corresponding decline in cell production. Quantifying the adverse effects on hematopoiesis is based on the properties of a single agent, the use of individual drugs within a combination chemotherapy regimen, and the course, or courses, of ...
Source: Journal of Pharmacy Practice - September 23, 2014 Category: Drugs & Pharmacology Authors: Barreto, J. N., McCullough, K. B., Ice, L. L., Smith, J. A. Tags: Drug-Induced Diseases Source Type: research
Drug-Induced Immune Thrombocytopenia
Thrombocytopenia is commonly seen in laboratory findings, especially in critically ill patients. Although the incidence is rare, drug-induced immune thrombocytopenia (DITP) is a serious complication that is often overlooked as a cause of thrombocytopenia. Over the last century, extensive research and data collection have been done in an attempt to better characterize DITP. Heparin-induced thrombocytopenia is the most common DITP and has distinct pathogenesis, diagnosis, and treatment options. However, other offending medications are less well known and have triggered many questions and constant search for answers. This rev...
Source: Journal of Pharmacy Practice - September 23, 2014 Category: Drugs & Pharmacology Authors: Kam, T., Alexander, M. Tags: Drug-Induced Diseases Source Type: research
Introduction: Drug Induced Diseases I
(Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - September 23, 2014 Category: Drugs & Pharmacology Authors: Saltiel, M. Tags: Drug-Induced Diseases Source Type: research
Pharmacogenetics in the Community Pharmacy: Thienopyridine Selection Post-Coronary Artery Stent Placement
Conclusion:
This case describes the potential for collaboration between pharmacists and physicians to optimize antiplatelet therapy through PGt testing. Points of consideration for others looking to implement related PGt services are also discussed. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - August 4, 2014 Category: Drugs & Pharmacology Authors: Kisor, D. F., Bright, D. R., Conaway, M., Bouts, B. A., Gerschutz, G. P. Tags: Case Report Source Type: research
Impact of High-Fidelity Simulation and Pharmacist-Specific Didactic Lectures in Addition to ACLS Provider Certification on Pharmacy Resident ACLS Performance
Conclusion:
Additional ACLS training requirements for pharmacy residents increased overall awareness of pharmacist roles and responsibilities and greatly improved resident confidence and comfort level in performing most essential pharmacist functions during ACLS situations. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - August 4, 2014 Category: Drugs & Pharmacology Authors: Bartel, B. J. Tags: Pharmacy Education Source Type: research
The Value of Pharmacy Residency Training for Health Systems: An Annotated Bibliography
Conclusion:
Pharmacy residency training programs are essential for pharmacists that will primarily engage in direct patient care activities. This annotated bibliography includes key publications that provide evidence of the value that pharmacy residents provide to the sponsoring health system. This manuscript will aid prospective residency directors interested in developing new residency positions at new institutions or for residency program directors interested in expanding the total number of resident positions available at the existing sites. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - August 4, 2014 Category: Drugs & Pharmacology Authors: Swan, J. T., Giouroukakis, M., Shank, B. R., Crona, D. J., Berger, K., Wombwell, E. Tags: Pharmacy Education Source Type: research
Prolonged Cholestatic Jaundice Associated With Flurbiprofen
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely consumed drugs throughout the world for pain relief. Although the adverse effects of NSAIDs to the liver are well known, flurbiprofen-induced liver cholestasis is extremely rare. Herein, we present a patient with prolonged icterus that is associated with the use of flurbiprofen without causing ductopenia. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - August 4, 2014 Category: Drugs & Pharmacology Authors: Dogan, S., Celikbilek, M., Demirkan, K., Yilmaz, S., Deniz, K., Gursoy, S., Yucesoy, M. Tags: Adverse Drug Event Source Type: research
Levomilnacipran (Fetzima): A New Serotonin-Norepinephrine Reuptake Inhibitor for the Treatment of Major Depressive Disorder
This article provides an overview of the mechanism of action, pharmacokinetic properties, clinical efficacy, safety, and tolerability of levomilnacipran ER. Relevant information was identified through a search of databases using the key word levomilnacipran. Additional information was obtained from fda.gov, by a review of the reference lists of identified articles, and from posters and abstracts from scientific meetings. Levomilnacipran ER, dosed once daily, is generally well tolerated and has demonstrated favorable effects compared to placebo in clinical trials of patients with major depressive disorder. The increased pot...
Source: Journal of Pharmacy Practice - August 4, 2014 Category: Drugs & Pharmacology Authors: Saraceni, M. M., Venci, J. V., Gandhi, M. A. Tags: Review Article Source Type: research
Dabigatran Use in the Real World: A Multihospital System Experience
Dabigatran etexilate, an oral direct thrombin inhibitor, was approved by the Food and Drug Administration to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation based on the outcomes of the Randomized Evaluation of Long-term anticoagulant therapY (RE-LY) study. Although this study provides robust data on the efficacy and safety of dabigatran, there may be differences in the drug use and outcomes in routine clinical practice following drug approval. In this retrospective chart review study, we describe the use of dabigatran in 160 patients in 4 adult hospitals (1 academic and 3 c...
Source: Journal of Pharmacy Practice - August 4, 2014 Category: Drugs & Pharmacology Authors: Kimmons, L. A., Kabra, R., Davis, M., Segars, B. V., Oliphant, C. S. Tags: Research Articles Source Type: research
Impact of a Pharmacist on Compliance With Hospital Core Measures
Conclusion:
Given the great impact that pharmacists can have on hospital core measure compliance, each hospital’s Pharmacy Department should evaluate ways to improve involvement in the quality programs at their hospitals. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - August 4, 2014 Category: Drugs & Pharmacology Authors: Oliphant, C. S., Twilla, J. D. Tags: Research Articles Source Type: research
Community-Based Pharmacists' Needs for HIV-Related Training and Experience
Conclusion:
In the current era of patient-centered care, a pharmacist that is well rounded—not just in dispensing antiretroviral medications but highly knowledgeable in different aspects of ART and HIV-specific patient care—can make a valuable contribution to the health care team. Pharmacy school curricula and continuing professional education need to be aligned to meet the knowledge and competency needs of community pharmacists who are strategically positioned to provide care to PLWH. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - August 4, 2014 Category: Drugs & Pharmacology Authors: Kibicho, J., Pinkerton, S. D., Owczarzak, J. Tags: Research Articles Source Type: research
Survey Regarding Provisions of a 3-Day Supply of an Antihypertensive
Conclusion/Implication:
This observational study demonstrates that provisions when dispensing an emergency supply of an antihypertensive medication are inconsistent. Further evaluation is warranted. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - August 4, 2014 Category: Drugs & Pharmacology Authors: Seal, D. W., Walton, J., Williams, S., Wilson, R., Smith-Benson, J. Tags: Research Articles Source Type: research
Pilot Study on the Impact of Evidence-Based Data on Oncology Pharmacists' Perceptions
Objectives:
The main objective was to evaluate whether the level of agreement of oncology hospital pharmacists with statements on their impact is influenced by the presence or absence of evidence-based data. The secondary objective was to evaluate the relative importance of evidence-based data among factors that may have contributed to oncology pharmacy practice evolution.
Methods:
Oncology pharmacists’ answered a Web questionnaire to measure their level of agreement with statements regarding their impact. Respondents answered the questionnaire before (pre) and after (post) being informed whether supporting evidence...
Source: Journal of Pharmacy Practice - August 4, 2014 Category: Drugs & Pharmacology Authors: Renet, S., Lebel, D., Prot-Labarthe, S., Therrien, R., Bourdon, O., Bussieres, J.-F. Tags: Research Articles Source Type: research
Pharmacists' Roles in Post-September 11th Disasters: A Content Analysis of Pharmacy Literature
Conclusions:
Data suggest that pharmacists may be prepared to respond to hurricanes and biological and chemical disasters in pharmaceutical supply and patient management roles. Future research should highlight efforts to prepare health systems for the effects of nuclear, radiological, and chemical disasters. (Source: Journal of Pharmacy Practice)
Source: Journal of Pharmacy Practice - August 4, 2014 Category: Drugs & Pharmacology Authors: Ford, H., von Waldner, T., Perri, M. Tags: Research Articles Source Type: research
Attention-Deficit/Hyperactivity Disorder
Attention-deficit/hyperactivity disorder (ADHD) is a neurobiological condition of childhood onset with the hallmarks of inattention, impulsivity, and hyperactivity. Inattention includes excessive daydreaming, disorganization, and being easily distracted. Impulsivity manifests as taking an action before fully thinking of the consequences. Hyperactivity includes an excessive rate of speech and motor activity. Complications of ADHD include academic failure, low self-esteem, poor work performance, substance abuse, criminal justice issues, and social problems. ADHD is predominately due to decreased activity in the frontal lobe....
Source: Journal of Pharmacy Practice - August 4, 2014 Category: Drugs & Pharmacology Authors: Bokor, G., Anderson, P. D. Tags: Continuing Education Article Source Type: research
