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No association of apolipoprotein B gene polymorphism and blood lipids in obese Egyptian subjects
Conclusion: This study reveals no significant association of apoB XbaI gene polymorphism (X) with obesity or lipid profiles in an Egyptian population. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - March 18, 2015 Category: Research Authors: Neda BogariAzza Abdel-LatifMaha HassanAbeer RamadanAhmed Fawzy Source Type: research

Thanks to all those who reviewed for Journal of Negative Results in Biomedicine in 2014
Contributing reviewersA peer-reviewed journal would not survive without the generous time and insightful comments of the reviewers, whose efforts often go unrecognized. Although final decisions are always editorial, they are greatly facilitated by the deeper technical knowledge, scientific insights, understanding of social consequences, and passion that reviewers bring to our deliberations. For these reasons, the Editor-in-Chief and Managing Editor of the journal warmly thank the reviewers whose comments helped to shape Journal of Negative Results in Biomedicine, for their invaluable assistance with review of manuscripts f...
Source: Journal of Negative Results in BioMedicine - March 6, 2015 Category: Research Authors: Bjorn OlsenBent Brachvogel Source Type: research

No effects of a 12-week supervised exercise therapy program on gait in patients with mild to moderate osteoarthritis: a secondary analysis of a randomized trial
To determine whether gait biomechanics in hip osteoarthritis patients change following exercise therapy interventions, gait analysis was performed following a 12-week supervised exercise therapy program, which revealed no changes to biomechanical variables during the stance phase of gait. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - March 5, 2015 Category: Research Authors: Ingrid EitzenLinda FernandesLars NordslettenMay Risberg Source Type: research

The 4-aminopiperidine series has limited anti-tubercular and anti-staphylococcus aureus activity
Conclusions: We were unable to derive any other analogs with MIC? (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - February 13, 2015 Category: Research Authors: N ChandrasekeraTorey AllingMai BaileyAaron KorkegianJames AhnYulia OvechkinaJoshua OdingoTanya Parish Source Type: research

Interference with protease-activated receptor 1 does not reduce damage to subventricular zone cells of immature rodent brain following exposure to blood or blood plasma
Conclusion: Interference with the thrombin-PAR1 system does not reduce the adverse effects of blood on germinal cells of the immature rodent brain. PAR1 interference is unlikely to be a useful treatment for reducing the brain damage that accompanies periventricular (germinal matrix) hemorrhage, a common complication of premature birth. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - February 4, 2015 Category: Research Authors: Xiaoyan MaoMarc Del Bigio Source Type: research

Chitosan-based scaffold modified with D-(+) raffinose for cartilage repair: an in vivo study
Conclusions: In conclusion, the present study highlights the limits of D-(+) raffinose-enriched chitosan for cartilage regeneration and offers useful information for further development of this material for tissue repair. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - January 14, 2015 Category: Research Authors: Francesca RavanettiCarlo GalliEdoardo ManfrediAnna CantoniEdoardo ScarpaGuido MacalusoAntonio Cacchioli Source Type: research

The high-affinity human IgG receptor Fc gamma receptor I (Fc¿RI) is not associated with vascular leakage of dengue
Background: Dengue is a major public health problem in many tropical and sub-tropical countries. Vascular leakage and shock are identified as the major causes of deaths in patients with severe dengue. Studies have suggested the potential role of Fc gamma receptors I (Fc?RI) in the pathogenesis of dengue. We hypothesized that the circulating level of Fc? receptor I could potentially be used as an indicator in assisting early diagnosis of severe dengue. Results: A selected cohort of 66 dengue patients including 42 dengue with signs of vascular leakage, and 24 dengue without signs of vascular leakage were identified and were ...
Source: Journal of Negative Results in BioMedicine - January 8, 2015 Category: Research Authors: Zaiharina ZamberiZuraihan ZakariaAbu Abdul AzizBenedict HengMasliza ZaidChristopher ChongFadzilah NoorSazaly Abu BakarHoh Boon Peng Source Type: research

Skeletal muscle atrophy in sedentary Zucker obese rats is not caused by calpain-mediated muscle damage or lipid peroxidation induced by oxidative stress
Conclusions: This study highlights that atrophy of Zucker rat skeletal muscle is not related to sarcolemmal damage, sustained hyperactivation of the calpain proteases or excessive lipid peroxidation. As such, establishing the correct pathways involved in atrophy is highly important so as to develop more specific treatment options that target the underlying cause. This study has eliminated two of the potential pathways theorised to be responsible. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 30, 2014 Category: Research Authors: Nancy PompeaniEmma RybalkaHeidy LatchmanRobyn MurphyKevin CroftAlan Hayes Source Type: research

Skeletal muscle atrophy in sedentary Zucker obese rats is not caused by calpain-mediated muscle damage or lipid peroxidation induced by oxidative stress
Conclusions: This study highlights that atrophy of Zucker rat skeletal muscle is not related to sarcolemmal damage, sustained hyperactivation of the calpain proteases or excessive lipid peroxidation. As such, establishing the correct pathways involved in atrophy is highly important so as to develop more specific treatment options that target the underlying cause. This study has eliminated two of the potential pathways theorised to be responsible. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 30, 2014 Category: Research Authors: Nancy PompeaniEmma RybalkaHeidy LatchmanRobyn MurphyKevin CroftAlan Hayes Source Type: research

Effects of antibody to receptor activator of nuclear factor ¿-B ligand on inflammation and cartilage degradation in collagen antibody-induced arthritis in mice
Conclusions: Our present study failed to show the effectiveness of an anti-RANKL antibody to ameliorate inflammation in the limbs or protect articular cartilage from degradation in a collagen antibody-induced arthritis mouse model. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 12, 2014 Category: Research Authors: Sakie FunatoAkihiro MatsunagaKoei OhYoichi MiyamotoKentaro YoshimuraJunichi TanakaDai SuzukiRisa UyamaHiroaki SuzukiKenji MishimaMasanori NakamuraOsamu NamikiKazuyoshi BabaKatsunori InagakiRyutaro Kamijo Source Type: research

The feasibility of ureteral tissue engineering using autologous veins: an orthotopic animal model with long term results
Conclusions: Venous grafts may be a potential source for ureteral reconstruction. The results of so far published ureteral tissue engineering projects reveal data up to 12 weeks after implantation. Even if the animal numbers of this study are small, there is an increasing rate of hydronephrosis revealing failure of ureteral tissue engineering with autologous matrices in time points longer than 3 months after implantation. Further investigations have to prove adequate clinical outcome and appropriate functional long-term results. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - November 8, 2014 Category: Research Authors: Oliver EngelRobert de PetriconiBjörn VolkmerKilian GustJens ManiAxel HaferkampRichard HautmannGeorg Bartsch Source Type: research

P2X7 protein expression and polymorphism in non-small cell lung cancer (NSCLC)
P2X7 protein expression has recently been identified in several tumors, highlighting its potential role as a cancer cell biomarker. However, evaluation of P2X7 expression and polymorphisms in non-small cell lung cancer revealed no significant difference in protein expression or genotype frequency. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - September 1, 2014 Category: Research Authors: Laura BoldriniMirella GiordanoGreta AlìAdele ServadioSerena PelliccioniCristina NiccoliAlfredo MussiGabriella Fontanini Source Type: research

Tracing the emergence of multidrug-resistant Acinetobacter baumannii in a Taiwanese hospital by evaluating the presence of integron gene intI1
Conclusions: Although the presence of the intI1 gene does not seem suitable for tracing MDRAB emergence in Changhua County, two predominant clones were identified by PFGE, and subsequent studies to identify whether these clones were responsible for original nosocomial infection are needed. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - August 14, 2014 Category: Research Authors: Chang-Hua ChenChieh-Chen Huang Source Type: research

Reduction in hSOD1 copy number significantly impacts ALS phenotype presentation in G37R (line 29) mice: implications for the assessment of putative therapeutic agents
Genomic signature differences were observed between the offspring of G37R mice obtained commercially compared with those from transgenic breeders, corresponding to differences in amyotrophic lateral sclerosis progression and overall lifespan. This could have major implications on the use of G37R mice in the development of amyotrophic lateral sclerosis therapeutics. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - August 8, 2014 Category: Research Authors: Pierre ZwiegersGrace LeeChristopher Shaw Source Type: research

A double-blind, randomized controlled, prospective trial assessing the effectiveness of oral corticoids in the treatment of symptomatic lumbar canal stenosis
Conclusion: The oral corticoid regimen used in this study was not effective in the treatment of lumbar canal stenosis. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - August 7, 2014 Category: Research Authors: Luiz RodriguesJamil Natour Source Type: research