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Comparison of vilanterol, a novel long-acting beta2 agonist, with placebo and a salmeterol reference arm in asthma uncontrolled by inhaled corticosteroids
This study investigated the efficacy of vilanterol, a novel long-acting beta2 agonist. Results indicated substantial improvements in patients of all treatment groups, with no statistical differences between vilanterol and the controls. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - June 13, 2014 Category: Research Authors: Jan LötvallEric BatemanWilliam BussePaul O¿ByrneAshley WoodcockWilliam TolerLoretta JacquesCaroline GoldfradEugene Bleecker Source Type: research

Lack of association between serotonin transporter 5-HTT gene polymorphism and endometriosis in an Italian patient population
Conclusions: Our results suggest that the 5-HTT L/S promoter polymorphism is not associated with susceptibility to endometriosis in the studied Italian patients. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - June 12, 2014 Category: Research Authors: Francesca MegiorniSerena RestaDeliar YazdanianGabriele CavaggioniClaudia LiaPierluigi Benedetti PaniciAntonio PizzutiMaria Grazia Porpora Source Type: research

Effects of camptothecin derivatives and topoisomerase dual inhibitors on Trypanosoma cruzi growth and ultrastructure
Conclusions: Taken together, our data showed that camptothecin is more efficient than its derivatives in decreasing T. cruzi proliferation. Furthermore, we conclude that drugs pertaining to a certain class of topoisomerase inhibitors may present different efficiencies as chemotherapeutical agents. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - June 10, 2014 Category: Research Authors: Otto LacombeAline ZumaCamila da SilvaWanderley de SouzaMaria Motta Source Type: research

Hemispheric differences in the surgical outcomes of patients with traumatic acute subdural hematoma
Conclusions: This study is probably the first to report that the left ASDH patients fared substantially worse than the right-sided counterparts. Future trials on traumatic ASDHs may benefit from considering hemispheric differences in the outcomes. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - May 31, 2014 Category: Research Authors: Joji InamasuMitsuhiro HasegawaTakuro HayashiYoko KatoYuichi Hirose Source Type: research

Modifiable cardiovascular disease risk factors as predictors of dementia death: pooling of ten general population-based cohort studies
Conclusions: In the present study, there was limited evidence that cardiovascular disease risk factors were related to dementia death. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - May 23, 2014 Category: Research Authors: G BattyTom RussJohn StarrEmmanuel StamatakisMika Kivimäki Source Type: research

Remembering Yoshifumi Ninomiya
No description available (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - April 23, 2014 Category: Research Authors: Bjorn Olsen Source Type: research

Pretreatment with Saccharomyces boulardii does not prevent the experimental mucositis in Swiss mice
Conclusions: S. boulardii was not able to prevent the effects of experimental mucositis induced by 5- Fluorouracil. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - April 11, 2014 Category: Research Authors: Tatiani MaioliBrenda de Melo SilvaMichelle DiasNivea PaivaValbert CardosoSimone FernandesCláudia CarneiroFlaviano dos Santos MartinsSimone de Vasconcelos Generoso Source Type: research

Urinary concentrations of ADAM 12 from breast cancer patients pre- and post-surgery vs. cancer-free controls: a clinical study for biomarker validation
This study aimed to establish the viability of urinary ADAM 12 as a diagnostic marker and explore the effects of surgical tumour removal on urinary levels. The results suggest ADAM12 may not correlate directly to the stage of breast cancer progression. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - April 1, 2014 Category: Research Authors: Erin Nyren-EricksonMichael BoutonMihir RavalJessica TotzauerSanku MallikNeville Alberto Source Type: research

Physical activity and the risk of postmenopausal breast cancer - the Norwegian Women and Cancer Study
Conclusions: The study results from this large Norwegian cohort do not support an association between physical activity at different periods of life and the risk of postmenopausal breast cancer. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - March 1, 2014 Category: Research Authors: Kristin BorchEiliv LundTonje BraatenElisabete Weiderpass Source Type: research

Opening peer-review: the democracy of science
With the current drive for improving transparency in biomedical and clinical research, JNRBM is taking the positive move towards an open peer-review policy. Daniel Shanahan and Editor-in-Chief Bjorn Olsen discuss this change in this editorial. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - January 24, 2014 Category: Research Authors: Daniel ShanahanBjorn Olsen Source Type: research

Journal of Negative Results in BioMedicine
Contributing reviewersA peer-reviewed journal would not survive without the generous time and insightful comments of the reviewers, whose efforts often go unrecognized. Journal of Negative Results in BioMedicine has been blessed by the support of highly-qualified peer reviewers, and the Editor-in-Chief, Bjorn Olsen, and staff of the journal would like to show their appreciation by thanking the following for their invaluable assistance with review of manuscripts for the journal in Volume 12 (2013). (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - January 20, 2014 Category: Research Authors: Daniel Shanahan Source Type: research

Prognostic limitations of the Eurotransplant-donor risk index in liver transplantation
Conclusions: The ET-DRI should not be used for donor organ allocation policies without further evaluation, e.g. in combination with relevant recipient variables. Robust and objective prognostic scores for donor organ allocation purposes are desperately needed to balance equity and utility in donor organ allocation. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 24, 2013 Category: Research Authors: Benedikt ReichertAlexander KaltenbornAlon GoldisHarald Schrem Source Type: research

Unexpected combined effects of NADH dehydrogenase subunit-2 237 Leu/Met polymorphism and green tea consumption on renal function in male Japanese health check-up examinees: a cross-sectional study
Background: NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism is associated with longevity in Japanese. A previous study has shown that ND2-237 Leu/Met polymorphism modulates the effects of green tea consumption on risk of hypertension. For men with ND2-237Leu, habitual green tea consumption may reduce the risk of hypertension. Moreover, there is a combined effect of ND2-237 Leu/Met polymorphism and alcohol consumption on risk of mildly decreased estimated glomerular filtration rate (eGFR) ( (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - November 20, 2013 Category: Research Authors: Akatsuki KokazeMamoru IshikawaNaomi MatsunagaKanae KaritaMasao YoshidaTadahiro OhtsuHirotaka OchiaiTakako ShirasawaHinako NanriHiromi HoshinoYutaka Takashima Source Type: research

The methodological quality of three foundational law enforcement drug influence evaluation validation studies
Conclusion: The accuracies reported by these studies do not quantify the accuracy of the DIE process now used by US law enforcement. These studies do not validate current DIE practice. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - November 4, 2013 Category: Research Authors: Greg Kane Source Type: research

Depression treatment and short-term healthcare expenditures among elderly Medicare beneficiaries with chronic physical conditions
Conclusion: Among the elderly Medicare beneficiaries with chronic physical conditions, depression treatment was associated with greater short-term healthcare expenditures. Future research needs to replicate these findings and also examine whether depression treatment reduces expenditures over a longer period of time. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - October 22, 2013 Category: Research Authors: Chan ShenNeel ShahPatricia FindleyUsha Sambamoorthi Source Type: research