Journal of Negative Results in BioMedicine 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Air ions and respiratory function outcomes: a comprehensive review
Conclusions:
Despite numerous experimental and analytical differences across studies, the literature does not clearly support a beneficial role in exposure to negative air ions and respiratory function or asthmatic symptom alleviation. Further, collectively, the human experimental studies do not indicate a significant detrimental effect of exposure to positive air ions on respiratory measures. Exposure to negative or positive air ions does not appear to play an appreciable role in respiratory function. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - September 9, 2013 Category: Research Authors: Dominik AlexanderWilliam BaileyVanessa PerezMeghan MitchellSteave Su Source Type: research
Biological constraints limit the use of rapamycin-inducible FKBP12-Inp54p for depleting PIP2 in dorsal root ganglia neurons
Conclusions:
Taken together, our data indicate that these knockin mice cannot be used to inducibly deplete PIP2 in DRG neurons. Moreover, our data suggest that high levels of endogenous FKBP12 could compete for binding to FRBPLF, hence limiting the use of rapamycin-inducible systems to cells with low levels of endogenous FKBP12. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - September 8, 2013 Category: Research Authors: Jaeda Coutinho-BuddSamuel SniderBrendan FitzpatrickJoseph RittinerMark Zylka Source Type: research
Serotonin: a novel bone mass controller may have implications for alveolar bone
As recent studies highlight the importance of alternative mechanisms in the control of bone turnover, new therapeutic approaches can be envisaged for bone diseases and periodontitis-induced bone loss. Recently, it has been shown that Fluoxetine and Venlafaxine, serotonin re-uptake inhibitors commonly used as antidepressants, can positively or negatively affect bone loss in rat models of induced periodontitis. Serotonin is a neurotransmitter that can be found within specific nuclei of the central nervous system, but can also be produced in the gut and be sequestered inside platelet granules. Although it is known to be mainl...
Source: Journal of Negative Results in BioMedicine - August 21, 2013 Category: Research Authors: Carlo GalliGuido MacalusoGiovanni Passeri Source Type: research
Clinical significance and diagnostic usefulness of serologic markers for improvement of outcome of tonsillectomy in adults with chronic tonsillitis
Background:
The aim of the present study was to explore serological biomarkers which predict the outcome of tonsillectomy for chronic tonsillitis.
Methods:
A case study in a University ENT department of 24 adult patients with chronic tonsillitis (CHT) in comparison to 24 patients with acute peritonsillar abscess (PTA) was performed. Blood samples for clinical routine hematological and serological parameters were assessed prior to surgery (T-1) and five days (T5) after tonsillectomy. Outcome 6 months later (T180) was documented using the Glasgow Benefit Inventory (GBI) and the Specific Benefits from Tonsillectomy Inventory...
Source: Journal of Negative Results in BioMedicine - July 1, 2013 Category: Research Authors: Silvia BohneRobert SiggelSvea SachseMichael KiehntopfMichael BauerEberhard StraubeOrlando Guntinas-Lichius Source Type: research
A phase 3 trial assessing the efficacy and safety of grass allergy immunotherapy tablet in subjects with grass pollen-induced allergic rhinitis with or without conjunctivitis, with or without asthma
Background:
Design and execution of immunotherapy trials for seasonal allergies may be complicated by numerous factors including variable allergy testing methods, pollen levels, and timing and intensity of other seasonal allergens. We evaluated grass allergy immunotherapy tablet (AIT) treatment in North American adults with grass pollen-induced allergic rhinitis with or without conjunctivitis (AR/C), with/without asthma.
Methods:
Subjects age 18--65 with clinical history of grass pollen--induced AR/C, with/without asthma were randomized 1:1 to once-daily 2800 BAU Timothy grass AIT (oral lyophilisate, Phleum pratense, 75,00...
Source: Journal of Negative Results in BioMedicine - June 1, 2013 Category: Research Authors: Kevin MurphySandra GawchikDavid BernsteinJens AndersenMartin Rud Pedersen Source Type: research
Effects of a commercial product containing guaraná on psychological well-being, anxiety and mood: a single-blind, placebo-controlled study in healthy subjects
Conclusions:
In healthy subjects a 5-day treatment with a commercial preparation of guaranà used according to labelled instructions provided no evidence for any major effects on psychological well-being, anxiety and mood. Considering the increasing popularity of guaranà-containing products sold as dietary supplements for fitness purposes, controlled studies are strongly warranted to assess their benefits in comparison to the labelled claims. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - May 25, 2013 Category: Research Authors: Gianluca SilvestriniFranca MarinoMarco Cosentino Source Type: research
Neuropathogenic Escherichia coli K1 does not exhibit proteolytic activities to exert its pathogenicity
Conclusions:
Neither zymographic assays nor protease assays detected proteolytic activities in either the whole bacteria or conditioned media of E. coli K1 strain E44 and E. coli K-12 strain HB101. These findings suggest that host cell monolayer disruptions and immune evasion strategies are likely independent of proteolytic activities of neuropathogenic E. coli K1. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - May 1, 2013 Category: Research Authors: Junaid IqbalMehak RajaniRuqaiyyah SiddiquiNaveed Khan Source Type: research
Comparative measurement of CNP and NT-proCNP in human blood samples: a methodological evaluation
Conclusions:
CNP and NT-proCNP are stable for at least two hours, even when sample processing is delayed or blood probes are stored at room temperature. NT-proCNP assay demonstrated more consistent and reliable data and should therefore be preferred for usage in clinical applications. Nevertheless, as recommended for ANP and BNP, immunoassays for CNP should also be standardized or harmonized in the future. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - April 1, 2013 Category: Research Authors: Andreas KuehnlJaroslav PelisekMartin BruckmeierWajima SafiHans-Henning Eckstein Source Type: research
Exclusion of eleven candidate genes for ocular melanosis in cairn terriers
Conclusions:
None of the 11 potential candidate genes selected are unlikely to be the gene locus for ocular melanosis in Cairn terriers. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - March 1, 2013 Category: Research Authors: Paige WinklerJoshua BartoeCeleste QuinonesPatrick VentaSimon Petersen-Jones Source Type: research
Circulating rotaviral RNA in children with rotavirus antigenemia
Conclusions:
Antigenemia is present in a significant number of patients with rotavirus diarrhea. Rotavirus viremia was absent in the children with rotavirus diarrhea who participated in our study, and was not indicated by the presence of antigenemia. The significance of circulating rotavirus antigen and genomic dsRNA in serum of patients with diarrhea deserves further study. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - February 1, 2013 Category: Research Authors: Kamruddin AhmedGulendam BozdayiMarcelo MituiSelim AhmedLuthful KabirDalgic BuketIlknur BostanciAkira Nishizono Source Type: research
Prolactin gene expression in primary central nervous system tumors
Conclusions:
Despite the presence of prolactin expression by IH, the lack of its expression by quantitative real-time PCR indicates that its presence in primary tumors in CNS is not a reflex of local production. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - January 14, 2013 Category: Research Authors: Graziella MendesJúlia Pereira-LimaMaria KohekGeraldine TrottMarlise Di DomenicoNelson FerreiraMiriam Oliveira Source Type: research
Human Endogenous Retrovirus K(HML-2) Gag and Env specific T-cell responses are not detected in HTLV-I-infected subjects using standard peptide screening methods
Conclusions:
Thus, although the limited scope of our screening prevents us from conclusively disproving our hypothesis, the current study does not provide data supporting a role for HERV-specific T-cell responses in HTLV-1 associated immunopathology. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - January 10, 2013 Category: Research Authors: R JonesFabio LealAaron HasenkrugAluisio SeguradoDouglas NixonMario OstrowskiEsper Kallas Source Type: research
Maternal undernutrition does not alter Sertoli cell numbers or the expression of key developmental markers in themid-gestation ovine fetal testis
Conclusions:
These data suggest that, unlike in the fetal ovary, maternal undernutrition for the first 110 days of gestation affects neither the morphology of the fetal testis nor the expression of gene products which regulate apoptosis. It is postulated that the effects of fetal undernutrition on testis function may be expressed through hypothalamic-pituitary changes. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - January 8, 2013 Category: Research Authors: Luis AndradeStewart RhindMichael RaeCarol KyleJamie JowettRichard Lea Source Type: research
TOPBP1 missense variant Arg309Cys and breast cancer in a German hospital-based case-control study
The DNA double strand break repair gene TOPBP1 has been suggested as a breast cancer susceptibility gene and a missense variant Arg309Cys was observed at elevated frequency in familial breast cancer cases compare... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - November 25, 2010 Category: Research Authors: Magda A Blaut, Natalia V Bogdanova, Michael Bremer, Johann H Karstens, Peter Hillemanns and Thilo Dörk Source Type: research
Does computer use pose a hazard for future long-term sickness absence?
The aim of the study was to investigate if weekly duration of computer use predicted sickness absence for more than two weeks at a later time. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - March 22, 2010 Category: Research Authors: Johan H Andersen and Sigurd Mikkelsen Source Type: research
