Journal of Negative Results in BioMedicine Journal of Negative Results in BioMedicine RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Ethanol exposure during the third trimester equivalent does not affect GABAA or AMPA receptor-mediated spontaneous synaptic transmission in rat CA3 pyramidal neurons
Ethanol exposure during the rodent equivalent to the 3rd trimester of human pregnancy (i.e., first 1–2 weeks of neonatal life) has been shown to produce structural and functional alterations in the CA3 hippocampa... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 2, 2015 Category: Research Authors: Brian Charles Baculis and Carlos Fernando Valenzuela Source Type: research

Effects of omega-3 fatty acids on arterial stiffness in patients with hypertension: a randomized pilot study
Conclusion: High-dose omega-3 fatty acids did not reduce arterial PWV or markers of inflammation among patients within a Latino-predominant population with hypertension.Clinical trial registrationNCT00935766, registered July 8 2009. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 2, 2015 Category: Research Authors: Mori KrantzEdward HavranekRocio PereiraBrenda BeatyPhilip MehlerCarlin Long Source Type: research

Ethanol exposure during the third trimester equivalent does not affect GABA A or AMPA receptor-mediated spontaneous synaptic transmission in rat CA3 pyramidal neurons
Conclusions: We show that an ethanol exposure paradigm known to inhibit synaptic plasticity mechanisms that may participate in the stabilization of GABAergic and glutamatergic synapses in CA3 pyramidal neurons does not produce lasting functional alterations in these synapses, suggesting that compensatory mechanisms restored the balance of excitatory and inhibitory synaptic transmission. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 2, 2015 Category: Research Authors: Brian BaculisCarlos Valenzuela Source Type: research

The rs361525 polymorphism does not increase production of tumor necrosis factor alpha by monocytes from alpha-1 antitrypsin deficient subjects with chronic obstructive pulmonary disease - a pilot study
Polymorphisms in the TNF-A gene have been associated with chronic obstructive pulmonary disease (COPD) in some case-control studies. Previous work has shown that COPD/chronic bronchitis subjects with alpha-1 a... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 1, 2015 Category: Research Authors: Jennie M. Gane, Robert A. Stockley and Elizabeth Sapey Source Type: research

The rs361525 polymorphism does not increase production of tumor necrosis factor alpha by monocytes from alpha-1 antitrypsin deficient subjects with chronic obstructive pulmonary disease - a pilot study
Conclusions: This small pilot study did not provide an explanation for the findings of earlier observations of the association of the rs361525 polymorphism with TNF-α in airways secretions. Possible reasons for the lack of concordance include the study of blood rather than tissue cells, the use of a single stimulant rather than biological secretions and the need for far greater subject numbers to overcome intra-subject variation in monocyte TNF-α production. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 1, 2015 Category: Research Authors: Jennie GaneRobert StockleyElizabeth Sapey Source Type: research

Early objective response may not be a prognostic factor of survival for patients with metastatic urothelial carcinoma: from a retrospective analysis of a cohort of 113 patients
Conclusions: This study confirms the prognostic factors previously reported in first-line chemotherapy for mUC. However, we failed to demonstrate that EOR was an independent predictive factor of OS. Nevertheless, an early response evaluation is recommended since early progression is an important parameter that can be used to decide whether treatment should be interrupted and changed for alternative strategies integrating the concept of personalized medicine or new immune therapies. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - November 10, 2015 Category: Research Authors: Guilhem RoubaudVéronique BroustePhillipe BeuzebocAude FléchonDiego TosiSandrine Lavau-DenesChristine ChevreauStéphane CulineStéphane OudardAmandine QuivyPhilippe PourquierNadine Houédé Source Type: research

MicroRNAs in urine are not biomarkers of multiple myeloma
In this study, we aimed to identify microRNA from urine of multiple myeloma patients that could serve as a biomarker for the disease. Results: Analysis of urine samples was performed using Serum/Plasma Focus PCR MicroRNA Panel (Exiqon) and verified using individual TaqMan miRNA assays for qPCR. We found 20 deregulated microRNA (p  (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - September 23, 2015 Category: Research Authors: Lenka Sedla¿íkováLenka Be¿¿eSo¿a NovosadováVeronika KubaczkováLenka RadováMichal StaníkMarta Krej¿íRoman HájekSabina ¿ev¿íková Source Type: research

A double-blind, randomised, placebo-controlled study of roxithromycin and doxycycline combination, roxithromycin alone, or matching placebo for 12 weeks in adults with frequent exacerbations of chronic obstructive pulmonary disease
Conclusions: Twelve-weeks of prophylaxis with roxithromycin/doxycycline combination or roxithromycin alone did not reduce COPD exacerbations in patients with history of frequent exacerbations. These findings do not support the use of these antibiotics to prevent exacerbations in COPD patients. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - September 7, 2015 Category: Research Authors: Eskandarain ShafuddinGraham MillsMark HolmesPhillippa PoolePeter MullinsPeter Black Source Type: research

Maternal exercise before and during pregnancy does not impact offspring exercise or body composition in mice
Conclusions: The current results conflict with previous findings in human and mouse models demonstrating that maternal exercise has the potential to alter offspring phenotypes. We discuss our negative findings in the context of the timing of the maternal exercise and the level of biological organization of the examined phenotypes within the offspring. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - August 3, 2015 Category: Research Authors: Scott KellyKunjie HuaJennifer WallaceSarah WellsDerrick NehrenbergDaniel Pomp Source Type: research

Sutherlandia frutescens may exacerbate HIV-associated neuroinflammation
Background: Neuroinflammation is central to the aetiology of HIV-associated neurocognitive disorders (HAND) that are prevalent in late stage AIDS. Anti-retroviral (ARV) treatments are rolled out relatively late in the context of neuroinflammatory changes, so that their usefulness in directly preventing HAND is probably limited. It is common practice for HIV+ individuals in developing countries to make use of traditional medicines. One such medicine is Sutherlandia frutescens - commonly consumed as a water infusion. Here its efficacy as an anti-inflammatory modality in this context was investigated in an in vitro co-culture...
Source: Journal of Negative Results in BioMedicine - July 18, 2015 Category: Research Authors: Luan AfricaCarine Smith Source Type: research

Negative results: negative perceptions limit their potential for increasing reproducibility
Negative results are an important building block in the development of scientific thought, primarily because most likely the vast majority of data is negative, i.e., there is not a favorable outcome. Only very limited data is positive, and that is what tends to get published, albeit alongside a sub-set of negative results to emphasize the positive nature of the positive results. Yet, not all negative results get published. Part of the problem lies with a traditional mind-set and rigid publishing frame-work that tends to view negative results in a negative light, or that only tends to reward scientists primarily for present...
Source: Journal of Negative Results in BioMedicine - July 7, 2015 Category: Research Authors: Jaime Teixeira da Silva Source Type: research

A systematic examination of brain volumetric abnormalities in recent-onset schizophrenia using voxel-based, surface-based and region-of-interest-based morphometric analyses
Conclusions: In the background of the conflicting findings in the literature, our findings indicate that brain morphometric abnormalities may not be directly related to the schizophrenia phenotype. Analysis of the reasons for the inconsistent results across studies as well as consideration of alternate sources of variability of brain morphology in schizophrenia such as epistatic and epigenetic mechanisms could perhaps advance our understanding of structural brain alterations in schizophrenia. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - June 12, 2015 Category: Research Authors: John JohnAmmu LukoseBhavani BagepallyHarsha HalahalliNagaraj MoilyAnupa VijayakumariSanjeev Jain Source Type: research

Case-control association between CCT-associated variants and keratoconus in a Saudi Arabian population
Conclusions: This is the first study investigating the association of these SNPs with KC in a population from Saudi Arabia. We replicated the same trend of MAF alteration of the association between the SNPs rs4894535 (FNDC3B, chr3: 171995605), rs7044529 (COL5A1, chr9: 137568051), rs11145951 (LCN12-PTGDS, chr9: 139860264) and rs2721051 (FOXO1, chr13: 41110884) and KC-risk as reported by a recently published GWAS. Consistently replicated population-based studies are necessary to identify and/or confirm genetic susceptibility for certain diseases. We acknowledge that the lack of significance in our study is due to our small s...
Source: Journal of Negative Results in BioMedicine - June 4, 2015 Category: Research Authors: Khaled Abu-AmeroInas HelwaAbdulrahman Al-MuammarShelby StricklandMichael HauserR. AllinghamYutao Liu Source Type: research

Preoperative endoscopic tattooing to mark the tumour site does not improve lymph node retrieval in colorectal cancer: a retrospective cohort study
Conclusion: This study shows that preoperative ink tattooing utilized to mark the site of the tumour does not improve adequate lymphadenectomy and lymph nodes yield from colorectal cancer specimens. Further studies are therefore needed to determine if preoperative colonoscopic tattooing to mark the tumour site can refine staging. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - May 7, 2015 Category: Research Authors: Carlo FeoMattia PortinariMichele ZuoloSimone TargaVincenzo MatareseRoberta GafàElena ForiniGiovanni Lanza Source Type: research

Waiting time and the psychosocial consequences of false-positive mammography: cohort study
Conclusion: We did not confirm that waiting time was associated with worse long-term psychosocial consequences but type II error (failure to detect a true difference) might be a plausible explanation for our results. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - April 30, 2015 Category: Research Authors: Bruno HelenoVolkert SiersmaJohn Brodersen Source Type: research