A double-blind, randomised, placebo-controlled study of roxithromycin and doxycycline combination, roxithromycin alone, or matching placebo for 12 weeks in adults with frequent exacerbations of chronic obstructive pulmonary disease

Conclusions: Twelve-weeks of prophylaxis with roxithromycin/doxycycline combination or roxithromycin alone did not reduce COPD exacerbations in patients with history of frequent exacerbations. These findings do not support the use of these antibiotics to prevent exacerbations in COPD patients.

http://www.jnrbm.com/content/14/1/15

Source: Journal of Negative Results in BioMedicine - September 7, 2015 Category: Research Authors: Eskandarain ShafuddinGraham MillsMark HolmesPhillippa PoolePeter MullinsPeter Black Source Type: research

A double-blind, randomised, placebo-controlled study of roxithromycin and doxycycline combination, roxithromycin alone, or matching placebo for 12&#160;weeks in adults with frequent exacerbations of chronic obstructive pulmonary disease

A double-blind, randomised, placebo-controlled study of roxithromycin and doxycycline combination, roxithromycin alone, or matching placebo for 12 weeks in adults with frequent exacerbations of chronic obstructive pulmonary disease