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The diagnostic value of the bronchoalveolar lavage in interstitial lung diseases
Bronchoalveolar lavage (BAL) is a diagnostic tool often used during the management of interstitial lung diseases (ILD). However, its diagnostic value in discrimination between entities comprising the very hete... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - March 1, 2017 Category: Research Authors: Boubacar Efared, G. Ebang-Atsame, Sani Rabiou, Abdoulsalam S. Diarra, Layla Tahiri, Nawal Hammas, Mohamed Smahi, Bouchra Amara, Mohamed C. Benjelloun, Mounia Serraj, Laila Chbani and Hinde El Fatemi Source Type: research

Antimicrobial activity of HL-60 cells compared to primary blood-derived neutrophils against Staphylococcus aureus
The human leukemia cell line HL-60 is considered an alternative cell culture model to study neutrophil differentiation and migration. The aim of this study was to characterize the suitability of HL-60 cells di... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - February 19, 2017 Category: Research Authors: Ragheda Yaseen, Stefanie Blodkamp, Petra L üthje, Friederike Reuner, Lena Völlger, Hassan Y. Naim and Maren von Köckritz-Blickwede Source Type: research

Lack of association between polymorphism rs540782 and primary open angle glaucoma in Saudi patients
To investigate whether polymorphism rs540782 on chromsome 1, in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene, is a risk factor for primary open angle glaucoma (POAG). (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - February 2, 2017 Category: Research Authors: Altaf A. Kondkar, Nikhil B. Edward, Hatem Kalantan, Abdullah S. Al-Kharashi, Saleh Altuwaijri, Gamal Mohamed, Tahira Sultan, Taif A. Azad and Khaled K. Abu-Amero Source Type: research

Do anti-amyloid beta protein antibody cross reactivities confound Alzheimer disease research?
Alzheimer disease (AD) research has focussed mainly on the amyloid beta protein (A β). However, many Aβ-and P3-type peptides derived from the amyloid precursor protein (APP) and peptides thought to derive from ... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - January 26, 2017 Category: Research Authors: Sally Hunter and Carol Brayne Source Type: research

Unspecific binding of cRNA probe to plaques in two mouse models for Alzheimer ’s disease
Alzheimer ’s disease (AD) is characterized by the pathological deposition of amyloid-β (Aβ) protein-containing plaques. Microglia and astrocytes are commonly attracted to the plaques by an unknown mechanism tha... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 16, 2016 Category: Research Authors: Anne Schaarschuch, Christoph Redies and Nicole Hertel Source Type: research

False data, positive results in neurobiology: moving beyond the epigenetics of blood and saliva samples in mental disorders
Many psychiatric diseases are influenced by a set of several genetic and environmental factors that genetics alone cannot explain. Specifically, in schizophrenia and bipolar disorder the absence of consistentl... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 12, 2016 Category: Research Authors: A. Cariaga-Martinez and R. Alel ú-Paz Source Type: research

Long-term effect of stents eluting 6-mercaptopurine in porcine coronary arteries
Drug-eluting stents (DES) have dramatically reduced restenosis rates compared to bare metal stents and are widely used in coronary artery angioplasty. The anti-proliferative nature of the drugs reduces smooth ... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 5, 2016 Category: Research Authors: Matthijs S. Ruiter, Albert Doornbos, Vivian de Waard, Robbert J. de Winter, Nico J. M. Attevelt, Rob Steendam and Carlie J. M. de Vries Source Type: research

Examining if being overweight really confers protection against dementia: Sixty-four year follow-up of participants in the Glasgow University alumni cohort study
Recent large-scale studies suggest that obesity and overweight may confer protection against future dementia. This observation could, however, be generated by reverse causality. That is, weight loss in the incipi... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - November 2, 2016 Category: Research Authors: G. David Batty, Bruna Galobardes, John M. Starr, Mona Jeffreys, George Davey Smith and Tom C. Russ Source Type: research

Dietary phosphate supplement does not rescue skeletal phenotype in a mouse model for craniometaphyseal dysplasia
Mutations in the human progressive ankylosis gene (ANKH; Mus musculus ortholog Ank) have been identified as cause for craniometaphyseal dysplasia (CMD), characterized by progressive thickening of craniofacial bon... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - October 26, 2016 Category: Research Authors: Yaling Liu, Eliane H. Dutra, Ernst J. Reichenberger and I-Ping Chen Source Type: research

Polymorphism rs7555523 in transmembrane and coiled-coil domain 1 (TMCO1) is not a risk factor for primary open angle glaucoma in a Saudi cohort
We investigated whether polymorphism rs7555523 (A  > C) in human transmembrane and coiled-coil domain 1 (TMCO1) gene is a risk factor for primary open angle glaucoma (POAG) in a Saudi cohort. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - September 29, 2016 Category: Research Authors: Altaf A. Kondkar, Ahmed Mousa, Taif A. Azad, Tahira Sultan, Abdullah Alawad, Saleh Altuwaijri, Saleh A. Al-Obeidan and Khaled K. Abu-Amero Source Type: research

Low density lipoprotein receptor-related protein 5 gene polymorphisms and osteoporosis in Thai menopausal women
Osteoporosis, characterized by low bone mineral density (BMD) and high bone fracture risk, is prevalent in Thai menopausal women. Genetic factors are known to play a key role in BMD. Low density lipoprotein re... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - September 1, 2016 Category: Research Authors: Anong Kitjaroentham, Hathairad Hananantachai, Benjaluck Phonrat, Sangchai Preutthipan and Rungsunn Tungtrongchitr Source Type: research

Evaluation of a novel virtual screening strategy using receptor decoy binding sites
This report shows the development and evaluation of a nov... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - August 23, 2016 Category: Research Authors: Hershna Patel and Andreas Kukol Source Type: research

Gastrokine 1 mRNA in human sera is not informative biomarker for gastric cancer
We aimed to ascertain if Gastrokine 1 mRNA in the sera of patients with gastric cancer might be an informative biomarker for the disease. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - July 25, 2016 Category: Research Authors: Valentina Villano, Chiara Stella Di Stadio, Antonella Federico, Filomena Altieri, Giuseppina Miselli, Maurizio De Palma, Emilia Rippa and Paolo Arcari Source Type: research

Is mindfulness protective against PTSD? A neurocognitive study of 25 Tsunami disaster survivors
It has been suggested that mindfulness is a protective factor that buffers individuals from experiencing severe posttraumatic stress following exposure to a trauma. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - July 20, 2016 Category: Research Authors: Christina Hagen, Lars Lien, Edvard Hauff and Trond Heir Source Type: research