Skeletal muscle atrophy in sedentary Zucker obese rats is not caused by calpain-mediated muscle damage or lipid peroxidation induced by oxidative stress
Conclusions:
This study highlights that atrophy of Zucker rat skeletal muscle is not related to sarcolemmal damage, sustained hyperactivation of the calpain proteases or excessive lipid peroxidation. As such, establishing the correct pathways involved in atrophy is highly important so as to develop more specific treatment options that target the underlying cause. This study has eliminated two of the potential pathways theorised to be responsible.
Source: Journal of Negative Results in BioMedicine - Category: Research Authors: Nancy PompeaniEmma RybalkaHeidy LatchmanRobyn MurphyKevin CroftAlan Hayes Source Type: research
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