Mitochondrial dysfunction in diabetes and the regulatory roles of antidiabetic agents on the mitochondrial function
The prevalence of type 2 diabetes mellitus (T2DM) is increasing rapidly with its associated morbidity and mortality; many pathophysiological pathways such as oxidative stress, inflammatory responses, adipokines, obesity ‐induced insulin resistance, improper insulin signaling, and beta cell apoptosis are associated with the development of T2DM. There is increasing evidence of the role of mitochondrial dysfunction in the onset of T2DM, particularly in relation to the development of diabetic complications. Here, the role of mitochondrial dysfunction in T2DM is reviewed together with its modulation by antidiabetic therapeuti...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Habib Yaribeygi,
Stephen L. Atkin,
Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research
Calpain ‐2 protects against heat stress‐induced cardiomyocyte apoptosis and heart dysfunction by blocking p38 mitogen‐activated protein kinase activation
In conclusion, our study suggests that heat stress reduces calpain‐2 expression, which then activates p38, leading to cardiomyocyte apoptosis and heart dysfunct ion. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Zhi ‐feng Liu,
Jing‐jing Ji,
Dong Zheng,
Lei Su,
Tianqing Peng Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Sulfonyl(thio)urea derivative induction of insulin secretion is mediated by potassium, calcium, and sodium channel signal transduction
ConclusionsSD diminish glycemia by inducing GLP ‐1 secretion and inhibiting disaccharidases. To our knowledge, this is the first report of an insulin secretagogue effect of SD that is mediated by potassium and calcium, as well as sodium, signal transduction. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Paola Miranda Sulis,
Betina Fernanda Dambr ós,
Alessandra Mascarello,
Adair Roberto Soares dos Santos,
Rosendo Augusto Yunes,
Ricardo José Nunes,
Marisa Jádna Silva Frederico,
Fátima Regina Mena Barreto Silva Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Ecto ‐5′‐nucleotidase (CD73) is a potential target of hepatocellular carcinoma
CD73 promotes hepatocellular carcinoma (HCC) growth and metastasis, in vitro and in vivo, mediated by epithelial growth factor receptor (EGFR). AbstractHigh expression of ecto ‐5′‐nucleotidase (CD73) has been reported in a number of epithelium origin malignancies. Here, we hypothesize that CD73 promotes hepatocellular carcinoma (HCC) growth and metastasis and that the effect is mediated by epithelial growth factor receptor (EGFR). HCC cells with different malignanci es and Tissue microarrays of the tumor and peritumoral liver tissues from 30 independent patients were used to examine CD73 and EGFR expression. Then, MT...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Shalaimaiti Shali,
Jiangang Yu,
Xin Zhang,
Xue Wang,
Youping Jin,
Minsheng Su,
Xiaohong Liao,
Jerry Yu,
Xiuling Zhi,
Ping Zhou Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Fifteen hub genes associated with progression and prognosis of clear cell renal cell carcinoma identified by coexpression analysis
In this study, our aim is to identify potential biomarkers that could effectively predict the prognosis and progression of ccRCC. First, we used The Cancer Genome Atlas (TCGA) RNA ‐sequencing (RNA‐seq) data of ccRCC to identify 2370 differentially expressed genes (DEGs). Second, the DEGs were used to construct a coexpression network by weighted gene coexpression network analysis (WGCNA). Moreover, we identified the yellow module, which was strongly related to the histolog ic grade and pathological stage of ccRCC. Then, the functional annotation of the yellow module and single‐samples gene‐set enrichment analysis of...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Yejinpeng Wang,
Liang Chen,
Gang Wang,
Songtao Cheng,
Kaiyu Qian,
Xuefeng Liu,
Chin ‐Lee Wu,
Yu Xiao,
Xinghuan Wang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Integrative proteomics and immunochemistry analysis of the factors in the necrosis and repair in acetaminophen ‐induced acute liver injury in mice
Our data provided a comprehensive report on the profile and dynamic changes of the liver proteins in AILI; the involvement of Gzmf and the role of Stat3 in necrosis were revealed; and the role of hepatocyte in liver self ‐repair was well clarified. AbstractAcetaminophen (APAP) overdose ‐induced acute liver injury (AILI) is a significant clinical problem worldwide, the hepatotoxicity mechanisms are well elucidated, but the factors involved in the necrosis and repair still remain to be investigated. APAP was injected intraperitoneally in male Institute of Cancer Research (ICR) mic e. Quantitative proteome analysis of liv...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Qin Feng,
Ningwei Zhao,
Wenkai Xia,
ChengJie Liang,
Guoxin Dai,
Jian Yang,
Jingxia Sun,
Lanying Liu,
Lan Luo,
Jie Yang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Ectopic nerve growth factor prevents proliferation in glioma cells by senescence induction
ConclusionsThese findings provide the first evidence that NGF can induce senescence of PLGG cells in a receptor ‐mediated fashion, thus supporting the hypothesis that in the clinical setting NGF might be beneficial to pediatric glioma patients. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Daniela Meco,
Angela Maria Di Francesco,
Linda Melotti,
Antonio Ruggiero,
Riccardo Riccardi Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Overexpression of novel lncRNA NLIPMT inhibits metastasis by reducing phosphorylated glycogen synthase kinase 3 β in breast cancer
A novel long noncoding RNA was found to inhibit mammary cell proliferation and motility. Inhibition of glycogen synthase kinase 3 β (GSK3β) activity restored novel lncRNA inhibiting proliferation and metastasis‐induced repression. AbstractLong noncoding RNAs (lncRNAs) are considered as regulators of gene expression in cancers. However, cancer profiling has little focused on noncoding genes. Here, we reported that RP11 –115N4.1 (here renamed novel lncRNA inhibiting proliferation and metastasis [NLIPMT]) was downregulated in breast cancer tissues. Ectopic expression of NLIPMT inhibited mammary cell proliferation, motil...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Yang Jiang,
Lili Lin,
Shen Zhong,
Yangjun Cai,
Fen Zhang,
Xiaobo Wang,
Rongrong Miao,
Baodan Zhang,
Shenmeng Gao,
Xiaoqu Hu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
A β stimulates microglial activation through antizyme‐dependent downregulation of ornithine decarboxylase
In this study, we investigated the role of Aβ in mediating microglial activation and polarization both in vitro and in vivo. Our results demonstrated that under the Aβ treatment, ornithine decarboxylase (ODC), a rate‐limiting enzyme in the regulation of arginine catabolism, regulates microglial activation by altering the antizyme (AZ) + 1 ribosomal frameshift. Furthermore, the restoration of ODC protein expression levels has profound effects on inhibition of Aβ‐induced M1 markers and thus attenuates microglial‐mediated cytotoxicity. Altogether, our findings suggested that Aβ may contribute to M1‐like activa...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Yu ‐Wen Cheng,
Chun‐Cheng Chang,
Ti‐Sheng Chang,
Hsin‐Hua Li,
Hui‐Chih Hung,
Guang‐Yaw Liu,
Chih‐Li Lin Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
The roles of moonlight ribosomal proteins in the development of human cancers
Moonlighting ribosomal proteins are constituents of ribosomes with important extra ‐ribosomal functions, the implications of which in the initiation and progression of human cancers have been demonstrated. The present review focuses on the role of key moonlight ribosomal proteins in the development of human cancers and the related molecular mechanisms. Abstract“Moonlighting protein” is a term used to define a single protein with multiple functions and different activities that are not derived from gene fusions, multiple RNA splicing, or the proteolytic activity of promiscuous enzymes. Different proteinous constituent...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Ghader Molavi,
Nasser Samadi,
Elaheh Zadeh Hosseingholi Tags: REVIEW ARTICLE Source Type: research
Interleukin ‐37 inhibits osteoclastogenesis and alleviates inflammatory bone destruction
Interleukin 37 downregulates osteoclastogenesis through direct and indirect actions AbstractExcessive osteoclast formation is one of the important pathological features of inflammatory bone destruction. Interleukin ‐37 (IL‐37) is an anti‐inflammatory agent that is present throughout the body, but it displays low physiological retention. In our study, high levels of the IL‐37 protein were detected in clinical specimens from patients with bone infections. However, the impact of IL‐37 on osteoclast form ation remains unclear. Next, IL‐37 alleviated the inflammatory bone destruction in the mouse in vivo. We used re...
Source: Journal of Cellular Physiology - November 10, 2018 Category: Cytology Authors: Ruohui Tang,
Jin Yi,
Jing Yang,
Yueqi Chen,
Wei Luo,
Shiwu Dong,
Jun Fei Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
The role of nervous system in adaptive response of bone to mechanical loading
The role of sensory and sympathetic nervous system in bone remodeling under mechanical loading. AbstractBone tissue is remodeled through the catabolic function of the osteoclasts and the anabolic function of the osteoblasts. The process of bone homeostasis and metabolism has been identified to be co ‐ordinated with several local and systemic factors, of which mechanical stimulation acts as an important regulator. Very recent studies have shown a mutual effect between bone and other organs, which means bone influences the activity of other organs and is also influenced by other organs and syst ems of the body, especially ...
Source: Journal of Cellular Physiology - November 9, 2018 Category: Cytology Authors: Yini Qiao,
Yang Wang,
Yimei Zhou,
Fulin Jiang,
Tu Huang,
Liujing Chen,
Jingxiang Lan,
Cai Yang,
Yutong Guo,
Shanyu Yan,
Zhangming Wei,
Juan Li Tags: MINI ‐REVIEW Source Type: research
Function and regulation of apelin/APJ system in digestive physiology and pathology
Journal of Cellular Physiology, EarlyView. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 3, 2018 Category: Cytology Authors: Zhen Huang,
Xuling Luo,
Meiqing Liu,
Linxi Chen Source Type: research
Expression of novel proteins by polyomaviruses and recent advances in the structural and functional features of agnoprotein of JC virus, BK virus, and simian virus 40
Journal of Cellular Physiology, EarlyView. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 3, 2018 Category: Cytology Authors: A. Sami Saribas,
Pascale Coric,
Serge Bouaziz,
Mahmut Safak Source Type: research
The antiproliferative effects of cold atmospheric plasma ‐activated media on different cancer cell lines, the implication of ozone as a possible underlying mechanism
Journal of Cellular Physiology, EarlyView. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 2, 2018 Category: Cytology Authors: Hesam Mokhtari,
Leila Farahmand,
Kiomars Yaserian,
Neda Jalili,
Keivan Majidzadeh ‐A Source Type: research
