The roles of moonlight ribosomal proteins in the development of human cancers

Moonlighting ribosomal proteins are constituents of ribosomes with important extra ‐ribosomal functions, the implications of which in the initiation and progression of human cancers have been demonstrated. The present review focuses on the role of key moonlight ribosomal proteins in the development of human cancers and the related molecular mechanisms. Abstract“Moonlighting protein” is a term used to define a single protein with multiple functions and different activities that are not derived from gene fusions, multiple RNA splicing, or the proteolytic activity of promiscuous enzymes. Different proteinous constituents of ribosomes have been shown to h ave important moonlighting extra‐ribosomal functions. In this review, we introduce the impact of key moonlight ribosomal proteins and dependent signal transduction in the initiation and progression of various cancers. As a future perspective, the potential role of these moonlight ribosomal protein s in the diagnosis, prognosis, and development of novel strategies to improve the efficacy of therapies for human cancers has been suggested.
Source: Journal of Cellular Physiology - Category: Cytology Authors: Tags: REVIEW ARTICLE Source Type: research