Microtia patients: Auricular chondrocyte ECM is promoted by CGF through IGF ‐1 activation of the IGF‐1R/PI3K/AKT pathway
ConclusionCGF ‐released IGF‐1 stimulates the synthesis of the auricular chondrocyte ECM via the IGF‐1R/PI3K/AKT signaling pathway. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Xia Chen,
Ruhong Zhang,
Qun Zhang,
Zhicheng Xu,
Feng Xu,
Datao Li,
Yiyuan Li Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Garcinol suppresses RANKL ‐induced osteoclastogenesis and its underlying mechanism
In conclusion, our data demonstrated that garcinol inhibited the RANKL‐induced osteoclastogenesis by suppressing the MAPK, NF‐κB, and PI3K‐AKT signaling pa thways and thus has potential as a novel therapeutic option for osteolytic bone diseases. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Yewei Jia,
Jiawei Jiang,
Xuanyuan Lu,
Tan Zhang,
Kangxian Zhao,
Weiqi Han,
Wanlei Yang,
Yu Qian Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Circulating visfatin levels and cancers risk: A systematic review and meta ‐analysis
Visfatin levels is abnormal in many types of cancers. There is a significant association between high circulating visfatin levels and increased risk of various cancers. Visfatin may represent a potential biomarker for early detection of cancers. AbstractVisfatin levels have been reported to be abnormal in many types of cancers. However, epidemiological studies yielded inconsistent results. Therefore, a meta ‐analysis was performed to assess the association between circulating visfatin levels and cancer risk. A systematic search was conducted for relevant studies in health‐related electronic databases up to March 2018. ...
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Masoumeh Mohammadi,
Faezeh Mianabadi,
Hassan Mehrad ‐Majd Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
TNF ‐α–TNFR signal pathway inhibits autophagy and promotes apoptosis of alveolar macrophages in coal worker's pneumoconiosis
Conclusion: TNF ‐α–TNFR signal pathway was involved in the occurrence and development of CWP by activating FAS–caspase‐8 and thus inhibiting autophagy while promoting apoptosis of AM. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Qingzeng Qian,
Xiangke Cao,
Bin Wang,
Yi Qu,
Qingqiang Qian,
Zhiqian Sun,
Fumin Feng Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Leukemia inhibitory factor inhibits the proliferation of gastric cancer by inducing G1 ‐phase arrest
Unlike LIF promotes tumor progression, we found LIF serves as a negative regulator of gastric cancer, inhibits metastasis and the proliferation. AbstractLeukemia inhibitory factor (LIF), a member of the interleukin ‐6 cytokine family, plays a complex role in cancer. LIF inhibits the proliferation and survival of several myeloid leukemia cells but promotes tumor progression and metastasis in many solid tumors. However, the relationship between LIF and gastric cancer has not been well understood. LIF was downr egulated in gastric cancer as detected by western blot analysis and immunohistochemistry (IHC). Notably, LIF was d...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Guoxing Xu,
Haibin Wang,
Weizheng Li,
Zengfu Xue,
Qi Luo Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Molecular aspects of pancreatic β‐cell dysfunction: Oxidative stress, microRNA, and long noncoding RNA
AbstractMetabolic syndrome is known as a frequent precursor of type 2 diabetes mellitus (T2D). This disease could affect 8% of the people worldwide. Given that pancreatic β‐cell dysfunction and loss have central roles in the initiation and progression of the disease, the understanding of cellular and molecular pathways associated with pancreatic β‐cell dysfunction can provide more information about the underlying pathways involved in T2D. Multiple lines evidenc e indicated that oxidative stress, microRNA, and long noncoding RNA play significant roles in various steps of diseases. Oxidative stress is one of the import...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Mohammad Javad Saeedi Borujeni,
Ebrahim Esfandiary,
Azar Baradaran,
Ali Valiani,
Mustafa Ghanadian,
Pilar Codo ñer‐Franch,
Reyhane Basirat,
Eulalia Alonso‐Iglesias,
Hamed Mirzaei,
Amid Yazdani Tags: REVIEW ARTICLE Source Type: research
MicroRNA ‐1271 functions as a potential tumor suppressor in hepatitis B virus–associated hepatocellular carcinoma through the AMPK signaling pathway by binding to CCNA1
This study indicated a potential therapeutic approach of downregulation of miR ‐1271 in HBV‐associated hepatocellular carcinoma treatment. AbstractHepatocellular carcinoma (HCC) is mainly associated with hepatitis B virus (HBV) infection and characterized by metastasizing and infiltrating adjacent and distant tissues. Notably, microRNA ‐1271 (miR‐1271) is a tumor suppressor in various cancers. Therefore, we evaluate the ability of miR‐1271 to influence cell proliferation, migration, invasion, and apoptosis in HBV‐associated HCC through the Adenosine monophosphate–activated protein kinase (AMPK) signaling path...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Yang Chen,
Zhen ‐Xian Zhao,
Fei Huang,
Xiao‐Wei Yuan,
Liang Deng,
Di Tang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Clusterin enhances AKT2 ‐mediated motility of normal and cancer prostate cells through a PTEN and PHLPP1 circuit
In human prostate cells, clusterin (CLU) overexpression was found to enhance the phosphorylation of AKT restricted to isoform 2. Mechanistically, this was explained by the finding that the phosphatase PHLPP1, known to dephosphorylate AKT2 at S474, is markedly downregulated by CLU, whereas miR ‐190, a negative regulator of PHLPP1, is upregulated. Moreover, we found that PTEN was heavily phosphorylated at the inhibitory site S380, contributing to the hyperactivation of AKT signaling. Remarkably, we also demonstrated that by keeping AKT2 phosphorylation high, CLU dramatically enhances the migratory behavior of prostate epit...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Jessika Bertacchini,
Laura Mediani,
Francesca Beretti,
Marianna Guida,
Aram Ghalali,
Federica Brugnoli,
Valeria Bertagnolo,
Emanuel Petricoin,
Francesco Poti,
Jessica Arioli,
Laura Anselmi,
Alessia Bari,
James McCubrey,
Alberto M. Martelli,
Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
The role of microRNAs regulating the expression of matrix metalloproteinases (MMPs) in breast cancer development, progression, and metastasis
MicroRNAs (miRNAs) regulate several biological and physiological processes in mammalian cells, including cellular proliferation, differentiation, apoptosis, and metabolism. Recent studies have confirmed the alteration of them during the cancer development. Matrix metalloproteinases (MMPs), belonging to the large family of proteases, have also been demonstrated to play crucial roles in tissue remodeling, and to support cancer progression and metastasis. There are several known miRNAs which regulate the MMP family and their expression. The expression profiles of miRNAs involved in MMP regulation, change during cancer progres...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Mahsa Javadian,
Tohid Gharibi,
Najibeh Shekari,
Meghdad Abdollahpour ‐Alitappeh,
Ali Mohammadi,
Arezoo Hossieni,
Hamed Mohammadi,
Tohid Kazemi Tags: MINI ‐REVIEW Source Type: research
Lycorine inhibits melanoma cell migration and metastasis mainly through reducing intracellular levels of β‐catenin and matrix metallopeptidase 9
Metastatic melanoma accounts for 60% of death for skin cancer. Although great efforts have been made to treat the disease in recent decades, effective drugs against metastatic melanoma are lack. We found that lycorine significantly suppressed melanoma cell migration and invasion in vitro, and decreased the metastasis of melanoma cells to lung tissues in mice by reducing intracellular levels of β‐catenin protein through degradation of the protein via the ubiquitin–proteasome pathway. Our findings support the notion that targeting the oncogenic β‐catenin signaling by lycorine is a new option to inhibit melanoma cell ...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Pan Zhang,
Mengli Zhang,
Di Yu,
Wenming Liu,
Lin Hu,
Bin Zhang,
Quansheng Zhou,
Zhifei Cao Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Long noncoding RNA –antisense noncoding RNA in the INK4 locus accelerates wound healing in diabetes by promoting lymphangiogenesis via regulating miR‐181a/Prox1 axis
ConclusionANRIL could promote lymphangiogenesis during the diabetic wound healing process via sponging miR ‐181a to enhance Prox1 expression, which might help design new therapy to improve the wound healing efficacy for diabetes. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Zhi ‐You He,
Tian‐Hong Wei,
Pi‐Hong Zhang,
Jie Zhou,
Xiao‐Yuan Huang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Biomaterial aided differentiation and maturation of induced pluripotent stem cells
Recent technological advancements in biomaterial scaffolds aids to improve the differentiation of induced pluripotent stem cells (iPSCs) with desired properties. Here, we discuss in detail with examples that different fabrication techniques incorporates physical and topographical or biochemical cues in the biomaterial scaffold which guides in the differentiation of iPSCs to a specific functional cell phenotype. AbstractEngineering/reprogramming differentiated adult somatic cells to gain the ability to differentiate into any type of cell lineage are called as induced pluripotent stem cells (iPSCs). Offering unlimited self ...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Bharath Kumar Velmurugan,
Lohanathan Bharathi Priya,
Paramasivan Poornima,
Li ‐Jen Lee,
Rathinasamy Baskaran Tags: REVIEW ARTICLE Source Type: research
CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review
Tumors have specific mechanisms to break T cell responses. CD8+ T cells are the key immune cells for killing cancer cells presenting major histocompatibility complex (MHC) class I molecules. For pursuing this purpose, the cells must first be primed by their cardinal interactions with dendritic cells (DCs), natural killer (NK) cells, and CD4+ T cells, among them play essential roles for this priming. Then, the primed cells are activated to form effector cytotoxic T lymphocytes (CTLs) for killing cancer cells via release of granules or induction of FasL‐mediated apoptosis. In the established tumors, however, the functi...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Bagher Farhood,
Masoud Najafi,
Keywan Mortezaee Tags: REVIEW ARTICLE Source Type: research
Protective role of microRNA ‐374 against myocardial ischemia‐reperfusion injury in mice following thoracic epidural anesthesia by downregulating dystrobrevin alpha‐mediated Notch1 axis
By inhibiting the activity of dystrobrevin ‐alph‐mediated Notch1 axis, miR‐374 could protect against myocardial Ischemia‐reperfusion injury in mice after thoracic epidural anesthesia. AbstractIschemia ‐reperfusion (I/R) injury often leads to myocardial apoptosis and necrosis. Studies have demonstrated the role microRNAs (miRs) played in myocardial I/R injury. Thus, we established a myocardial I/R injury model and a thoracic epidural anesthesia (TEA) model in mice to explore whether microRNA‐3 74 (miR‐374) affects myocardial I/R injury. We collected myocardial tissues to evaluate whether TEA exerts a protectio...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Zheng Zhao,
Yun Zhao,
Li Ying ‐Chun,
Lei Zhao,
Wei Zhang,
Jian‐Guo Yang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Roles of Nrf2/HO ‐1 and HIF‐1α/VEGF in lung tissue injury and repair following cerebral ischemia/reperfusion injury
CIRI can lead to remote organ injury in the lungs. The Nrf2/HO ‐1 antioxidative stress pathway minimizes pulmonary free radical injury, and HIF‐1α/VEGF advances angiogenesis and repair of the alveolar–capillary barrier. These findings provide a theoretical basis for clinical treatment. AbstractCerebral ischemia/reperfusion injury (CIRI) leads to injury in distant organs, most commonly the lungs, although limited studies have examined self ‐protective mechanisms during CIRI‐induced lung injury. Here, we investigated self‐protective mechanisms that attenuate stress‐related injury and promote the angiogenetic r...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Jianhua Fan,
Hui Lv,
Jie Li,
Yuqin Che,
Baoning Xu,
Zuo Tao,
Wenjun Jiang Tags: RAPID COMMUNICATION Source Type: research
