Flavonoid genistein protects bone marrow sinusoidal blood vessels from damage by methotrexate therapy in rats
Flavonoid genistein may have a potency to protect bone marrow sinusoids during methotrexate therapy, which is associated, at least partially, with its indirect effect of promoting angiogenic factor vascular endothelial growth factor expression in osteoblasts and its direct effect of enhancing nitric oxide production in sinusoidal endothelial cells. AbstractCancer chemotherapy can cause significant damage to the bone marrow (BM) microvascular (sinusoidal) system. Investigations must now address whether and how BM sinusoidal endothelial cells (SECs) can be protected during chemotherapy. Herein we examined the potential prote...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Mohammadhossein Hassanshahi,
Yu ‐Wen Su,
Samira Khabbazi,
Chia‐Ming Fan,
Ke‐Ming Chen,
Ju‐Fang Wang,
Airong Qian,
Peter R. Howe,
De‐Wen Yan,
Hou‐De Zhou,
Cory J. Xian Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
CircRNA fibroblast growth factor receptor 3 promotes tumor progression in non ‐small cell lung cancer by regulating Galectin‐1‐AKT/ERK1/2 signaling
The dysregulation of the circular RNA (circRNA) expression is involved in the progression of several cancers, including non ‐small cell lung cancer (NSCLC). Together, these data provide mechanistic insights into circRNA FGFR3 (circFGFR3)‐mediated regulation of both the AKT and ERK1/2 signaling pathways by sponging miR‐22‐3p and increasing Gal‐1 expression. AbstractThe dysregulation of circular RNA (circRNA) expression is involved in the progression of several cancers, including non ‐small cell lung cancer (NSCLC). However, the role and underlying molecular mechanisms of circRNA FGFR3 (circFGFR3) in NSCLC progr...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Bai ‐Quan Qiu,
Peng‐Fei Zhang,
Dian Xiong,
Jian‐Jun Xu,
Xiang Long,
Shu‐Qiang Zhu,
Xu‐Dong Ye,
Yin Wu,
Xu Pei,
Xue‐Mei Zhang,
Yong‐Bing Wu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
c ‐Src kinase contributes on endothelial cells mechanotransduction in a heat shock protein 70‐dependent turnover manner
1. c ‐Src triggers proliferative and survival signals in response to a circuit of differential tensional forces; 2. Extracellular matrix remodeling‐related scenario is rigorously modulated: possible role of c‐Src on delivering signals; 3. Heat shock proteins (HSPs) were identified in response to hy pertensive stress in vitro; 4. 20S proteasome‐related genes were overexpressed and suggested protein turnover. AbstractShear stress changes are associated with a repertory of signaling cascade modulating vascular phenotype. As shear stress ‐related tensional forces might be associated with pathophysiological susceptibi...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Tha ís Silva Pinto,
Célio Junior da Costa Fernandes,
Rodrigo Augusto da Silva,
Anderson Moreira Gomes,
José Cavalcante Souza Vieira,
Pedro de M. Padilha,
Willian F. Zambuzzi Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
MiR ‐145‐modulated SOX9‐mediated hypospadias through acting on mitogen‐activated protein kinase signaling pathway
In conclusion, SOX9, which was regulated by both miR‐145 and miR‐145/MAPK signaling, could be involved in the pathogenesis of hypospadias. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Yafeng Shang,
Yanjie Kang,
Jiantao Sun,
Pengtao Wei,
Jinhui Yang,
Han Zhang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
MRS1754 inhibits proliferation and migration of bladder urothelial carcinoma by regulating mitogen ‐activated protein kinase pathway
MRS1754 inhibits proliferation and migration of bladder urothelial carcinoma (BUC) cells. Bay60 ‐6583 could reverse the inhibitory effect of MRS1754 on BUC cells proliferation and migration. MRS1754 inhibits progression of BUC by suppressing the phosphorylation of the mitogen‐activated protein kinase (MAPK) pathway. AbstractBladder urothelial carcinoma (BUC) is one of the most common urological malignancies. Our previous study found that adenosine A2b receptor (A2bR) was upregulated in BUC tissues and cells. In the present study, we investigated the effect of MRS1754 (a selective A2bR antagonist) on cell proliferation ...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Yihong Zhou,
Xi Chu,
Ye Yi,
Zheng Hao,
Xiaoping Zheng,
Tang Yuxin,
Yingbo Dai Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Endoplasmic reticulum stress and unfolded protein response profile in quadriceps of sarcopenic patients with respiratory diseases
Endoplasmic reticulum (ER) stress and an exaggerated unfolded protein response (UPR) were observed in the vastus lateralis (VL) muscle of patients with respiratory sarcopenia and cachexia, particularly in those with lung cancer (LC). The three branches of UPR were similarly upregulated in muscles of cancer cachectic patients, whereas in the sarcopenic chronic obstructive pulmonary disease (COPD) patients, inositol ‐requiring enzyme (IRE) 1 arm was mostly upregulated in their VL. The differential expression profile of ER stress and UPR markers observed in chronic and acute respiratory diseases offers a niche for the desig...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Esther Barreiro,
Anna Salazar ‐Degracia,
Antonio Sancho‐Muñoz,
Joaquim Gea Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
IL ‐17 and IL‐22 elicited by a DNA vaccine encoding ROP13 associated with protection against Toxoplasma gondii
in BALB/c mice
AbstractToxoplasma gondii, an intracellular parasitic protozoan, is capable of infecting man and all warm ‐blooded animals. Cell‐mediated immunity is vital in mounting protective responses againstT. gondii infection. Recent studies have shown that T ‐helper (Th) 17 responses may play a key role in parasite control. In this current study, we constructed a DNA vaccine encodingT. gondii ROP13 in a pcDNA vector. Groups of BALB/c mice were immunized intramuscularly with pcROP13 or controls and challenged with the RH strain ofT. gondii. The results showed that immunization with pcROP13 could elicit an antibody response aga...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Paria Alizadeh,
Ehsan Ahmadpour,
Ahmad Daryani,
Tohid Kazemi,
Adel Spotin,
Mahmoud Mahami ‐Oskouei,
Robin J Flynn,
Yaghob Azadi,
Saba Rajabi,
Siamak Sandoghchian Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Upregulation of transient receptor potential melastatin 6 channel expression by rosiglitazone and all ‐trans‐retinoic acid in erlotinib‐treated renal tubular epithelial cells
Rosiglitazone and all ‐trans‐retinoic acid (ATRA) increased transient receptor potential melastatin 6 (TRPM6) expression in renal tubular epithelial cells. Rosiglitazone and ATRA increased Mg2+ influx. Rosiglitazone and ATRA may reverse the reduction in Mg2+ reabsorption caused by antiepidermal growth factor receptor (anti ‐EGFR) drugs. AbstractAnti ‐epidermal growth factor receptor (EGFR) drugs including erlotinib cause a side effect of hypomagnesemia. In lung adenocarcinoma A549 cells, anticancer agents such as cisplatin and doxorubicin dose‐dependently increased toxicity, but the effects were significantly sup...
Source: Journal of Cellular Physiology - November 21, 2018 Category: Cytology Authors: Aya Manabe,
Chisa Furukawa,
Hajime Hasegawa,
Toshiyuki Matsunaga,
Satoshi Endo,
Akira Ikari Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Hypericum perforatum in the treatment of psychiatric and neurodegenerative disorders: Current evidence and potential mechanisms of action
ConclusionSt. John's wort may exert potent antidepressant effects and represents an efficacious and safe treatment. However, the current clinical evidence regarding the efficacy ofH. perforatum in other psychiatric and neurodegenerative disorders is not sufficient to draw a robust conclusion. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 21, 2018 Category: Cytology Authors: Nahid Zirak,
Mojtaba Shafiee,
Ghasem Soltani,
Mohammad Mirzaei,
Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research
Specific knockdown of WNT8b expression protects against phosphate ‐induced calcification in vascular smooth muscle cells by inhibiting the Wnt–β‐catenin signaling pathway
WNT8b knockdown terminates phosphate ‐induced vascular calcification in vascular smooth muscle cells by inhibiting the Wnt–β‐catenin signaling pathway. In the last 10 years, the prevalence, significance, and regulatory mechanisms of vascular calcification (VC) have gained increasing recognition. The aim of this study is to explore the action ofWNT8b in the development of phosphate ‐induced VC through its effect on vascular smooth muscle cells (VSMCs) in vitro by inactivating the Wnt–β‐catenin signaling pathway. To explore the effect ofWNT8b on the Wnt –β‐catenin signaling pathway and VC in vitro, β‐gl...
Source: Journal of Cellular Physiology - November 21, 2018 Category: Cytology Authors: Bin ‐Yao Tian,
Li Yao,
Zi‐Tong Sheng,
Peng‐Zhi Wan,
Xiao‐Bo Qiu,
Jian Wang,
Tian‐Hua Xu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Anticancer properties of tocotrienols: A review of cellular mechanisms and molecular targets
Vitamin E TTs have gained interest due to their health benefits in chronic diseases. In particular, TTs were reported to exert significant antitumor activity in a wide range of cancer cells, by counteracting cell growth or proliferation, metastasis and angiogenesis. Recent studies pointed out that TTs exert a synergistic antitumor effect on cancer cells when given in combination with either standard antitumor agents or natural compounds with anticancer activity. These results, together with the safety of TT administration in healthy subjects, suggest that these compounds might represent a new chemopreventive or anticancer ...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Marina Montagnani Marelli,
Monica Marzagalli,
Fabrizio Fontana,
Michela Raimondi,
Roberta Manuela Moretti,
Patrizia Limonta Tags: REVIEW ARTICLE Source Type: research
Stat3 activation is critical for pluripotency maintenance
This study presents an overview of the critical roles of signal transducer and activator of transcription 3 (Stat3) activation in the pluripotency maintenance of embryonic stem (ES) cells, somatic cell reprogramming, and na ïve‐primed pluripotent states conversion of ES cells. AbstractSignal transducer and activator of transcription 3 (Stat3) is a cytoplasmic transcription with many important functions, including regulation of cell proliferation, differentiation, survival, angiogenesis, and immune response. Besides, it plays critical roles in regulating the pluripotency. With the ability of self ‐renewal and different...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Yan Zhang,
Dan Wang,
Jia Xu,
Yuebing Wang,
Fengxia Ma,
Zongjin Li,
Na Liu Tags: MINI REVIEW Source Type: research
Regulation of tumor angiogenesis by microRNAs: State of the art
This review focuses on tumor angiogenesis regulation by microRNAs and the mechanism underlying this regulation. MicroRNAs (miRNAs, miRs) are small (21 –25 nucleotides) endogenous and noncoding RNAs involved in many cellular processes such as apoptosis, development, proliferation, and differentiation via binding to the 3′‐untranslated region of the target mRNA and inhibiting its translation. Angiogenesis is a hallmark of cancer, which provide s oxygen and nutrition for tumor growth while removing deposits and wastes from the tumor microenvironment. There are many angiogenesis stimulators, among which vascular endothel...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Nasser H. Goradel,
Nejad Mohammadi,
Hamed Haghi ‐Aminjan,
Bagher Farhood,
Babak Negahdari,
Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research
Action mechanisms of n ‐3 polyunsaturated fatty acids on the oocyte maturation and developmental competence: Potential advantages and disadvantages
There is a large body of evidence showing that n ‐3 polyunsaturated fatty acids (PUFAs) have benefits on general health. This review discusses molecular mechanisms by which n‐3 PUFAs affect oocyte maturation and developmental competence. Infertility is a growing problem worldwide. Currently, in vitro fertilization (IVF) is widely performed to treat infertility. However, a high percentage of IVF cycles fails, due to the poor developmental potential of the retrieved oocyte to generate viable embryos. Fatty acid content of the follicular microenvironment can affect oocyte maturation and the subsequent developmental compet...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Reza Zarezadeh,
Amir Mehdizadeh,
Jo L. M. R. Leroy,
Mohammad Nouri,
Shabnam Fayezi,
Masoud Darabi Tags: MINI REVIEW Source Type: research
The clinical importance of CD4+CD7 − in human diseases
In this review, we first focus on the clinical importance of CD4+CD7− T cells in human disease and also explain the possible function of these cells. Secondly, we also investigate if the CD4+CD7− T cells are resistant to apoptosis. The CD7 antigen is a member of the immunoglobulin superfamily that expresses on the surface of all thymocytes, a majority of mature T cells, and also natural killer cells. Interestingly, under physiological and different pathological conditions, the loss of CD7 antigen occurred in the subset of CD4+ memory T cells. Various functions have been proposed for CD7, including its role in the activ...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Saeed Mohammadian Haftcheshmeh,
Amir Tajbakhsh,
Mohaddese Kazemi,
Seyed ‐Alireza Esmaeili,
Fatemeh Mardani,
Mostafa Fazeli,
Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research
