CircRNA fibroblast growth factor receptor 3 promotes tumor progression in non ‐small cell lung cancer by regulating Galectin‐1‐AKT/ERK1/2 signaling

The dysregulation of the circular RNA (circRNA) expression is involved in the progression of several cancers, including non ‐small cell lung cancer (NSCLC). Together, these data provide mechanistic insights into circRNA FGFR3 (circFGFR3)‐mediated regulation of both the AKT and ERK1/2 signaling pathways by sponging miR‐22‐3p and increasing Gal‐1 expression. AbstractThe dysregulation of circular RNA (circRNA) expression is involved in the progression of several cancers, including non ‐small cell lung cancer (NSCLC). However, the role and underlying molecular mechanisms of circRNA FGFR3 (circFGFR3) in NSCLC progression remains unknown. Here, we used quantitative real‐time polymerase chain reaction to validate that circFGFR3 expression was higher in NSCLC tissues than in the p aratumor tissues. Furthermore, our study indicated that the forced circFGFR3 expression promoted NSCLC cell invasion and proliferation. Mechanistically, we found that circFGFR3 promoted NSCLC cell invasion and proliferation via competitively combining with miR‐22‐3p to facilitate the galectin‐ 1 (Gal‐1), p‐AKT, and p‐ERK1/2 expressions. Clinically, we revealed that the high circFGFR3 expression correlates with the poor clinical outcomes in patients with NSCLC. Together, these data provide mechanistic insights into the circFGFR3‐mediated regulation of both the AKT and ERK1/2 signal ing pathways by sponging miR‐22‐3p and increasing Gal‐1 expression.

Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Bai ‐Quan Qiu, Peng‐Fei Zhang, Dian Xiong, Jian‐Jun Xu, Xiang Long, Shu‐Qiang Zhu, Xu‐Dong Ye, Yin Wu, Xu Pei, Xue‐Mei Zhang, Yong‐Bing Wu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research