Sulfonyl(thio)urea derivative induction of insulin secretion is mediated by potassium, calcium, and sodium channel signal transduction

ConclusionsSD diminish glycemia by inducing GLP ‐1 secretion and inhibiting disaccharidases. To our knowledge, this is the first report of an insulin secretagogue effect of SD that is mediated by potassium and calcium, as well as sodium, signal transduction.

Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Paola Miranda Sulis, Betina Fernanda Dambr ós, Alessandra Mascarello, Adair Roberto Soares dos Santos, Rosendo Augusto Yunes, Ricardo José Nunes, Marisa Jádna Silva Frederico, Fátima Regina Mena Barreto Silva Tags: ORIGINAL RESEARCH ARTICLE Source Type: research