N6-methyladenosine RNA methylation regulators contribute to the progression of prostate cancer
In this study, we analyzed the characteristic expression of m6A regulators in PCa and castration-resistant prostate cancer (CRPC). UALCAN and cBioPortal were used to estimate the clinical value and genetic alterations of m6A regulators, respectively. The correlation between m6A regulators and androgen receptor (AR) was assessed using Gene Expression Profiling Interactive Analysis (GEPIA) by Pearson correlation statistics. Total m6A levels were detected in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice and PCa cell lines. Results showed that the expression of methyltransferase-like 3 (METTL3) and YTH domain fa...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Qunying Wu, Xing Xie, Yiming Huang, Shanshan Meng, Youcheng Li, Huifeng Wang, Yanling Hu Tags: Research Paper Source Type: research
Diagnostic and prognostic value of FOXD1 expression in head and neck squamous cell carcinoma
This study evaluated the expression of FOXD1 and its role in head and neck squamous cell carcinoma (HNSCC). We mined the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases for expression profiles, clinical significance, and potential mechanisms of FOXD1in HNSCC. Our validation cohort consisted of FOXD1 mRNA expression in 162 paired HNSCC and adjacent normal tissues, as determined using quantitative real-time polymerase chain reaction. FOXD1 expression was upregulated in HNSCC in the public databases and in the validation cohort. The expression level of FOXD1 was associated with DNA amplification and met...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Shijie Qiu, Dan Li, Zhisen Shen, Qun Li, Yi Shen, Hongxia Deng, Yidong Wu, Chongchang Zhou Tags: Research Paper Source Type: research
Decoding Immune Heterogeneity of Melanoma and identifying immune-prognostic hub genes
In this study, we analyzed gene expression of 468 melanoma cases from the TCGA database, which led to the identification of three melanoma clusters (representedby low, median and high infiltration) that display unique immune features. We found that the microenvironment clusters had substantial prognostic efficacy. The median cluster was characterized by an inability to draw immune cells, highlighting possible immune escape mechanisms, and lower CXCL9 and CXCL10 expression, which was correlated to poor prognosis. Deep molecular characterization of immune cells, cytolytic-activity and tumor-inflammatory status revealed diver...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Yu Zhang, Siyu Hao, Yingli Gao, Weina Sun, Yuzhen Li Tags: Research Paper Source Type: research
Nogo-B receptor is required for stabilizing TGF- β type I receptor and promotes the TGF- β 1-induced epithelial-to-mesenchymal transition of non-small cell lung cancer
Conclusions: Our findings provide a novel role of NgBR in modulating TGF-β1-induced EMT and propose NgBR as a new therapeutic target for treating NSCLC patients. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Donghua Wu, Baofeng Zhao, Yang Song, Xinming Chi, Hailu Fu, Tiantong Guan, Liyuan Zhang, Xueguang Yang, Ke Hu, Rong Huang, Xiaomeng Jin, Qing Robert Miao, Shujuan Shao Tags: Research Paper Source Type: research
MRI-Based Radiomic Model for Preoperative Risk stratification in Stage I Endometrial Cancer
Conclusions: MRI-based radiomic model has great potential in prediction of low-risk ECs. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Jingya Chen, Hailei Gu, Weimin Fan, Yaohui Wang, Shuai Chen, Xiao Chen, Zhongqiu Wang Tags: Research Paper Source Type: research
The oncogenic role of protein kinase D3 in cancer
Protein kinase D3 (PRKD3), a serine/threonine kinase, belongs to protein kinase D family, which contains three members: PRKD1, PRKD2, and PRKD3. PRKD3 is activated by many stimuli including phorbol esters, and G-protein-coupled receptor agonists. PRKD3 promotes cancer cell proliferation, growth, migration, and invasion in various tumor types including colorectal, gastric, hepatic, prostate, and breast cancer. Accumulating data supports that PRKD3 is a promising therapeutic target for treatment of cancer. This review discusses the functions and mechanisms of PRKD3 in promoting tumorigenesis and tumor progression of various ...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Yan Liu, Hang Song, Yehui Zhou, Xinxing Ma, Jing Xu, Zhenghong Yu, Liming Chen Tags: Review Source Type: research
Identification of Seven Cell Cycle-Related Genes with Unfavorable Prognosis and Construction of their TF-miRNA-mRNA regulatory network in Breast Cancer
Breast cancer (BC), with complex tumorigenesis and progression, remains the most common malignancy in women. We aimed to explore some novel and significant genes with unfavorable prognoses and potential pathways involved in BC initiation and progression via bioinformatics methods. BC tissue-specific microarray datasets of GSE42568, GSE45827 and GSE54002, which included a total of 651 BC tissues and 44 normal breast tissues, were obtained from the Gene Expression Omnibus (GEO) database, and 124 differentially expressed genes (DEGs) were identified between BC tissues and normal breast tissues via R software and an online Ven...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Zhipeng Hong, Qinglan Wang, Chengye Hong, Meimei Liu, Pengqin Qiu, Rongrong Lin, Xiaolan Lin, Fangfang Chen, Qiuhuang Li, Lingling Liu, Chuan Wang, Debo Chen Tags: Research Paper Source Type: research
Diagnostic Accuracy of MRI for Detecting Cervical Invasion in Patients with Endometrial Carcinoma: A Meta-Analysis
Conclusions: MRI shows high specificity for detecting cervical infiltration in endometrial carcinoma. Using DWI or a 3.0-T device may improve the pooled sensitivity. DCE-MRI demonstrates higher pooled sensitivity and specificity than T2WI. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Qiu Bi, Guoli Bi, Junna Wang, Jie Zhang, Hongliang Li, Xiarong Gong, Lixiang Ren, Kunhua Wu Tags: Research Paper Source Type: research
Comparison of Endoscopic Submucosal Dissection Application on Mucosal Tumor and Subepithelial Tumor in stomach
Conclusions: Comparing ESD between gastric mucosal tumor and subepithelial tumor, ESD had similar efficiency in curative treatment. However, ESD in subepethelial tumor encountered higher perforation and lesser delay bleeding. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Wen-Hung Hsu, Tzung-Shiun Wu, Meng-Shu Hsieh, Yu-Min Kung, Yao-Kuang Wang, Jeng-Yih Wu, Fang-Jung Yu, Chao-Hung Kuo, Yu-Chung Su, Jaw-Yuan Wang, Deng-Chyang Wu, Huang-Ming Hu Tags: Research Paper Source Type: research
Upregulation of miR-1254 promotes Hepatocellular Carcinoma Cell Proliferation, Migration, and Invasion via Inactivation of the Hippo-YAP signaling pathway by decreasing PAX5
In conclusion, miR-1254 promoted proliferation, migration, and invasion of HCC cells via decreasing Hippo signaling through targeting PAX5 in vitro and in vivo. This miRNA might be a therapeutic target for HCC. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Xu Lu, Chao Yang, Yuanchang Hu, Jian Xu, Chengyu Shi, Jianhua Rao, Weixin Yu, Feng Cheng Tags: Research Paper Source Type: research
A Novel Nomogram for Predicting the Survival of Patients with Invasive Upper Tract Urothelial Carcinoma
Conclusion: An accurate novel nomogram that is superior to the current AJCC-TNM staging system was established for the prediction of CSS after RNU for invasive UTUC. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Zaishang Li, Xueying Li, Yonghong Li, Ying Liu, Peng Du, Zenqing Liu, Kefeng Xiao Tags: Research Paper Source Type: research
Establishment and Validation of a Preoperative MRI-based Nomogram for Predicting the Risk of Malignancy in Patients with Breast Tumor
Conclusion: The MRI-based nomogram can be used to achieve an accurate individualized risk prediction of malignancy and reduce unnecessary breast biopsy. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Jianguo Lai, Jinjiang Lin, Hongli Wang, Yi Sun, Yudong Li, Huan Tian, Shiyu Shen, Cui Tan, Huanhuan Liu, Fengyan Yu Tags: Research Paper Source Type: research
Overexpression of TC2N is associated with poor prognosis in gastric cancer
Conclusions: Our results show that high level of TC2N correlates with poor prognosis in patients with gastric cancer and promotes the development of gastric cancer. Thus, TC2N expression can serve as a prognostic biomarker for patients with gastric cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Jianbo Xu, Xinde Ou, Jin li, Qinbo Cai, Kaiyu Sun, Jingning Ye, Jianjun Peng Tags: Research Paper Source Type: research
ADP-Ribosylation Factor Like GTPase 4C (ARL4C) augments stem-like traits of glioblastoma cells by upregulating ALDH1A3
Glioma cells with stem cell-like properties are crucial for tumor initiation, progression and therapeutic resistance. Therefore, identifying specific factors in regulating stem-like traits is critical for the design of novel glioma therapeutics.Herein, we reported that ADP-Ribosylation Factor Like GTPase 4C (ARL4C) was highly expressed in glioma stem-like cells (GSLCs). GSLCs, determined by the efficiency of sphere formation in vitro and tumor growth in vivo, was increased by overexpression of ARL4C. ARL4C induced the tumorigenesis through ALDH1A3. Analyses of 325 patient specimens showed that ARL4C was highly expressed in...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Qian Chen, Wen-juan Fu, Xiao-peng Tang, Lu Wang, Qin Niu, Shuai Wang, Yong Lin, Mian-fu Cao, Rong Hu, Hai-Yan Wen, Yan Wang, Xia Zhang, Xiao-Hong Yao Tags: Research Paper Source Type: research
Hypoxia Inducible Factor-1alpha (HIF-1A) plays different roles in Gallbladder Cancer and Normal Gallbladder Tissues
Conclusions: Our findings provide evidence for the first time that HIF-1A is expressed in normal gallbladder tissues. Nuclear HIF-1A and cytoplasm HIF-1A plays different roles in GBC and normal gallbladder tissues. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Youliang Wu, Delong Meng, Yexiang You, Ruochuan Sun, Min Fu, Qiang Yan, Shangxin Zhang, Zheng Fang, Junjun Bao, Yongxiang Li Tags: Research Paper Source Type: research
