Overexpression of HIPK2 removes the transrepression of proapoptotic genes mediated by the CtBP1-p300-FOXO3a complex and increases the chemosensitivity in osteosarcoma cells
Decreased expression of proapoptotic genes can lead to the chemoresistenance in cancer therapy. Carboxyl-terminal binding protein 1 (CtBP1), a transcriptional corepressor with multiple oncogenic effects, has been previously identified to suppress the expression of two proapoptotic genes [BAX (BCL2 associated X) and BIM (Bcl-2 interacting mediator of cell death)] by assembling a complex with the Forkhead box O3 (FOXO3a) transcription factor and the p300 histone acetyltransferase. However, the upstream regulatory signaling of the CtBP1-p300-FOXO3a complex is obscure, and the effects of changing this signaling on chemosensiti...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Ning Duan, Wentao Zhang, Zhong Li, Liang Sun, Tao Song, Zirui Yu, Xun Chen, Wei Ma Tags: Research Paper Source Type: research
Study on the correlation between Helicobacter Pylori and biological characteristics of early Gastric Cancer
Conclusion: HP infection is related to the tumor site and mucosal inflammatory infiltration of EGC. The malignant degree of EGC complicated with HP infection is higher, and most of them are mixed type. The degree of HP infection was positively correlated with the degree of invasion and malignancy of ECG. Furthermore, the tumor indicator HER2 is closely related to HP infection, and the detection of HP combined with HER2 is of great significance in the discovery of EGC and the evaluation of its malignancy. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Guanqun Chao, Xinli Chen, Shuo Zhang Tags: Research Paper Source Type: research
Combination of oncolytic adenovirus targeting SATB1 and docetaxel for the treatment of castration-resistant prostate cancer
Conclusion: The combination of oncolytic adenovirus ZD55-SATB1 and chemotherapy provides a novel approach to effective therapy of prostate cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Lijun Mao, Haiyuan Yu, Sai Ma, Ziyang Xu, Fukun Wei, Chunhua Yang, Junnian Zheng Tags: Research Paper Source Type: research
Ethyl acetate subfractions from ethanol extracts of fermented oats (Avena sativa L.) exert anti-cancer properties in vitro and in vivo through G2/M and S Phase arrest and apoptosis
Conclusions: EASs exhibited anti-cancer activities in vitro and in vivo via cell cycle arrest and apoptosis. This finding suggests that polyphenol-enriched composition from fermented oats might become a promising candidate for impeding the development and progression of liver cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Nanhai Zhang, Liang Zhao, Shengbao Cai, Xiang Zeng, Wei Wu, Baoping Ji, Feng Zhou Tags: Research Paper Source Type: research
Screening and bioinformatical analysis of differentially expressed genes in nasopharyngeal carcinoma
Conclusions: Core genes of NPC were screened out by bioinformatical analysis in the present study and these genes may serve as prognostic and diagnostic biomarkers for NPC. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Weiqian Guo, Xiaomin Zheng, Lei Hua, Xianbin Zheng, Yangyang Zhang, Bin Sun, Zhenchao Tao, Jin Gao Tags: Research Paper Source Type: research
Identification of hub genes-based predictive model in hepatocellular carcinoma by robust rank aggregation and regression analysis
Conclusion: A novel six hub genes predictive risk model for HCC has been established based on multiple datasets analyses, providing novel features for the prediction of HCC patients' outcome. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Di Wu, Yun Pan, Xueyong Zheng Tags: Research Paper Source Type: research
JP3 enhances the toxicity of cisplatin on drug-resistant gastric cancer cells while reducing the damage to normal cells
Conclusions: JP3 enhanced the inhibitory effects of DDP on tumor growth while reduced toxic side effects of DDP on normal cells. The results of this study provide a new insight for the treatment of drug-resistant GC. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Yi Zhang, Junjie Chen, Zhen Che, Chuanjun Shu, Dongyin Chen, Kun Ding, Aiping Li, Jianwei Zhou Tags: Research Paper Source Type: research
Multidisciplinary team consultation for resectable Gastric Cancer: A propensity score matching analysis
Conclusion: MDT consultation has limited effects on improving the staging accuracy and treatment outcomes including survival of patients with resectable gastric cancer. Poor patient compliance may be a factor affecting the effectiveness of MDT consultation. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Yonghe Chen, Jun Xiang, Dan Liu, Jian Xiao, Fei Xiong, Kaikai Wei, Aihong Liu, Shi Chen, Yaxi Zhu, Xiaochun Meng, Junsheng Peng Tags: Research Paper Source Type: research
Androgen receptor (AR) decreases HCC cells migration and invasion via miR-325/ACP5 signaling
Hepatocellular carcinoma (HCC) is the most 5th commonly diagnosed and 2nd most lethal tumor in the world. The obvious gender advantage of HCC indicates that androgen receptor (AR) may play an important role in the tumor occurrence, develop and metastasis of HCC. Here we found that decreased AR could alter miR-325 to increase ACP5 expression in HCC cells, to increase HCC cells migration and invasion capacities. Mechanism dissection revealed that AR could regulate miR-325 expression through transcriptional regulation and miR-325 might directly target the 3'UTR of ACP5-mRNA to suppress its translation. The in vivo orthotopic ...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Xiwu Ouyang, Lemeng Feng, Guodong Liu, Lei Yao, Zhiming Wang, Shiqing Liu, Yao Xiao, Gewen Zhang Tags: Research Paper Source Type: research
ARRB1 Drives Gallbladder Cancer Progression by Facilitating TAK1/MAPK Signaling Activation
Gallbladder carcinoma (GBC) is the most common malignancy of the biliary tract, with a dismal 5-year survival of 5%. Recently, ARRB1, as a molecular scaffold, has been proposed to participate in the progression of multiple malignancies. However, the effect and regulatory mechanisms of ARRB1 in GBC have not been investigated. Our study aimed to explore the biological functional status and the possible molecular mechanisms of ARRB1 with respect to GBC progression. The survey showed that human GBC tissues exhibited increased levels of ARRB1 compared with normal tissues, and the high expression of ARRB1 was associated with poo...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Xudong Zhang, Zhijun Kong, Xiaoliang Xu, Xiao Yun, Jiadeng Chao, Dong Ding, Tao Li, Yuan Gao, Naifu Guan, Chunfu Zhu, Xihu Qin Tags: Research Paper Source Type: research
Prognostic significance of FSCN family in multiple myeloma
In this study, we used four independent Gene Expression Omnibus (GEO) datasets to explore the relationships between FSCN1-3 expression profiles and patient survival in MM. We found that FSCN1 was dramatically down-regulated in MM compared to normal donors (p < 0.001) and monoclonal gammopathy of undetermined significance (MGUS) (p = 0.032). Patients with high expression of FSCN1 and FSCN2 had significantly longer OS (p = 0.023 and 0.028, respectively). Univariate and multivariate analysis showed that FSCN1 (p = 0.003, 0.002) and FSCN2 (p = 0.018, 0.013) were independent favorable prognostic factors for OS in MM. Moreov...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Cong Deng, Chaozeng Si, Xu Ye, Qiang Zhou, Tiansheng Zeng, Zeyong Huang, Wenhui Huang, Pei Zhu, Qingfu Zhong, Zhihua Wu, Huoyan Zhu, Qing Lin, Wenjuan Zhang, Lin Fu, Yongjiang Zheng, Tingting Qian Tags: Research Paper Source Type: research
Clinical importance of ADC in the prediction of 125I in the treatment for gliomas
Conclusions: Pre-125I implantation ADC analysis can stratify prognosis in 125I-treated patients with glioma, which may aid in choosing a suitable therapy for glioma patients. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Congxiao Wang, Zhijian Xu, Song Wang, Lijing Peng, Wei Zhang, Xueda Li, Lili Yang, Ying Luan, Tao Su, Zixiang Li, Xiaokun Hu Tags: Research Paper Source Type: research
Cyr61 mediates oxaliplatin resistance in colorectal cancer cells by regulating Bcl-xL expression
In this study, we aimed to investigate the role of Cyr61 in the L-OHP resistance of CRC cells and examine the underlying mechanism. Our findings showed that the mRNA and protein levels of Cyr61 in L-OHP-resistant cells were significantly increased compared with those in nonresistant cells. Knockdown of Cyr61 enhanced the chemosensitivity of L-OHP-resistant cells to L-OHP. Mechanistically, we found that overexpression of Cyr61 decreased L-OHP-induced apoptosis in drug-resistant CRC cells through the regulation of Bcl-xL. Collectively, our results revealed for the first time that Cyr61 plays a crucial role in the resistance ...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Yanfang Song, Yanli Kang, Zhen Lin, Menglu Zeng, Pengchong Shi, Jia Lin, Pingxia Lu, Li Luo, Yingping Cao, Xianjin Zhu Tags: Research Paper Source Type: research
Corpora Cavernos invasion vs. Corpus Spongiosum invasion in Penile Cancer: A systematic review and meta-analysis
Conclusions: The systematic comparison suggests that patients with CS invasion had better CSS than those with CC invasion. CC invasion was associated with a high risk of LNM. The conclusions should be validated by large-scale studies. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Zaishang Li, Xueying Li, Wayne Lam, Yabing Cao, Jiunhung Geng, Antonio Augusto Ornellas, Fangjian Zhou, Hui Han Tags: Research Paper Source Type: research
Reduced miR-16 levels are associated with VEGF upregulation in high-risk myelodysplastic syndromes
Conclusion: These data suggest that miR-16 may play a role in angiogenesis in higher-risk MDS by targeting VEGF and therefore modulating MDS progression. MiR-16 might be a novel therapeutic target in higher-risk MDS. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Bei Xiong, Yanbo Nie, Yalan Yu, Shixuan Wang, Xuelan Zuo Tags: Research Paper Source Type: research
