Comparison of Proteomics Profiles Between Xenografts Derived from Cell Lines and Primary Tumors of Thyroid Carcinoma
In this study, proteomic profiles of tumor tissues from patients, included anaplastic thyroid carcinoma (ATC) and papillary thyroid carcinoma, and xenografts (8305C, 8505C, FRO, BAPAP and IHH4) were obtained using HPLC-tandem mass spectrometry and compared based on all proteins detected (3,961), cancer-related proteins and druggable proteins using pairwise Pearson's correlation analysis. The human tissue showed low proteomic similarity to the ATC cell lines (8305C, r = 0.344-0.416; 8505C, 0.47-0.579; FRO, 0.267-0.307) and to PTC cell lines (BCPAP, 0.303-0.468; IHH4, 0.262-0.509). Human tissue showed the following similarit...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Luo Fang, Yu-jia Liu, Yi-wen Zhang, Zong-fu Pan, Li-ke Zhong, Lie-hao Jiang, Jia-feng Wang, Xiao-wei Zheng, Ling-ya Chen, Ping Huang, Ming-hua Ge, Zhuo Tan Tags: Research Paper Source Type: research
Brucine inhibits proliferation of glioblastoma cells by targeting the G-quadruplexes in the c-Myb promoter
The proto-oncogene c-Myb plays an important role in cell proliferation, and its upregulation affects the development of glioblastomas. G-quadruplexes are secondary DNA or RNA structures that usually form in the promoter region of oncogenes, including c-Myb, and regulate the expression of these genes. The traditional Chinese medicine, brucine, is a ligand of the G-quadruplexes located in the promoter region of c-Myb. The present study investigated the therapeutic effects and mechanism of action of brucine in U87, LN18, and LN229 cells in vitro and in vivo. Our results showed that brucine suppressed the growth of these cells...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Qiaochu Liu, Qunhui Wang, Chuanqi Lv, Ziqiang Liu, Haijun Gao, Yong Chen, Gang Zhao Tags: Research Paper Source Type: research
Sequential administration of anti-PD-1 and anti-Tim-3 combined with an SA-GM-CSF-anchored vaccine overcomes adaptive immune resistance to reject established bladder cancer
Program death receptor-1 (PD-1) and T-cell immunoglobulin and mucin domain-containing protein-3 (Tim-3) play an important role in tumor immune evasion. PD-1 blockade could produce an effective anti-tumor effect but the response rate was low due to lacking of tumor infiltrating lymphocytes (TILs) and existing of other negative regulatory pathways. Streptavidin(SA)-GM-CSF surface-anchored tumor cells vaccine could induce specific anti-tumor immune response. However, this vaccine failed to induce regression of established tumor because it also up-regulated PD-1 expression on tumor cells dependent on IFNγ and up-regulated...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Xinji Zhang, Guang Liu, Xianghua Shi, Xiaojun Shi, Jinlong Li, Lijun Mo, Jimin Gao, Zhaolin Long, Wanlong Tan Tags: Research Paper Source Type: research
GPRC5A: An emerging prognostic biomarker for predicting malignancy of Pancreatic Cancer based on bioinformatics analysis
Conclusion: GPRC5A may act as an oncogene in the progression of PaCa and could be a prognostic biomarker in predicting survival of PaCa. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Xuetian Qian, Chengfei Jiang, Shanshan Shen, Xiaoping Zou Tags: Research Paper Source Type: research
Can American Joint Committee on Cancer prognostic groups be individualized in patients undergoing surgery for Stage IV invasive upper tract Urothelial Carcinoma?
Conclusions: Stage IV patients were stratified into two prognostically different risk groups depending on metastasis or grade. The subclassification of stage IV can increase the level of prognostic detail and individualize the prediction of survival in invasive UTUC patients. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Zaishang Li, Xueying Li, Ying Liu, Jiequn Fang, Xueqi Zhang, Kefeng Xiao Tags: Research Paper Source Type: research
Aberrant KIF23 expression is associated with adverse clinical outcome and promotes cellular malignant behavior through the Wnt/ β -catenin signaling pathway in Colorectal Cancer
Conclusion: These results suggest that KIF23 may act as a putative oncogene and a potential therapeutic target in CRC. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Zhiyu Ji, Aoning Mi, Mengmeng Li, Quanying Li, Changjiang Qin Tags: Research Paper Source Type: research
Nodal is involved in chemoresistance of renal cell carcinoma cells via regulation of ABCB1
Renal cell carcinoma (RCC) is the third most frequent malignancy within urological oncology. Understanding mechanisms of chemoresistance in RCC cell is important for therapy and drug development. We established cisplatin (CDDP) resistant RCC cells by treating cells with increasing concentrations of CDDP. Nodal, an important embryonic morphogen, was increased in RCC/CDDP cells. Targeted inhibition of Nodal via its siRNA or neutralization antibody restored sensitivity of RCC resistant cells to CDDP treatment. It was due to that si-Nodal can decrease expression of P-glycoprotein (P-gp, encoded by ABCB1), one important ATP-bin...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Xingwang Zhu, Dongwei Xue, Jia Liu, Fengming Dong, Yongzhi Li, Yili Liu Tags: Research Paper Source Type: research
Syntaxin 2 promotes colorectal cancer growth by increasing the secretion of exosomes
Conclusions: Our data provide evidence that STX2 promotes CRC growth by increasing exosomes secretion of CRC cells; And the modulation of STX2 in exosomes secretion correlates with Rab8a. Thus, our study identified a new mechanism of STX2 in CRC growth and may provide a possible strategy for CRC therapy. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Yongxia Wang, Yongzhen Li, Hong Zhou, Xinlai Qian, Yuhan Hu Tags: Research Paper Source Type: research
R-split-EPOCH plus high dose methotrexate in untreated diffuse large B cell lymphoma with MYC rearrangement or double expression of MYC and BCL-2
Conclusions: R-split-EPOCH plus HD-MTX regimen is an effective and feasible treatment option for DE DLBCL and DLBCL with MYC rearrangement. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Peng Sun, Yu Wang, Cui Chen, Hang Yang, Man Nie, Xiao-Qing Sun, Xiao-Hua He, Wen-Qi Jiang, Zhi-Ming Li Tags: Research Paper Source Type: research
Co-expression of PD-L1 and HIF-1 α predicts poor prognosis in Patients with Non-small Cell Lung Cancer after surgery
Conclusion: PD-L1 and HIF-1α may serve as attractive independent worse prognostic biomarkers for NSCLC patients and the combined evaluation of PD-L1 and HIF-1α may also be valuable for prognosis judgment. Additionally, expression of PD-L1 was positively correlated with HIF-1α, which may provide evidences for a novel combinational therapy targeting PD-L1 and HIF-1α in NSCLC patients. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Hongmei Zheng, Yue Ning, Yuting Zhan, Sile Liu, Yang Yang, Qiuyuan Wen, Songqing Fan Tags: Research Paper Source Type: research
Peri-tumoral brain edema associated with glioblastoma correlates with tumor recurrence
This study also highlights the importance of resection of PTBE tissue to not only reduce the mechanical obstruction associated with edema but also to delay recurrence of glioblastoma. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Xingping Qin, Rui Liu, Farhana Akter, Lingxia Qin, Qiurong Xie, Yanfei Li, Haowen Qiao, Wen Zhao, Zhihong Jian, Renzhong Liu, Songlin Wu Tags: Research Paper Source Type: research
NEK2 regulates cellular proliferation and cabergoline sensitivity in pituitary adenomas
Conclusions: Collectively, our results suggest that NEK2 might be a potential therapeutic target for prolactinoma. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Fangfang Jian, Yuhao Sun, Qingfang Sun, Benyan Zhang, Liuguan Bian Tags: Research Paper Source Type: research
Anlotinib suppresses metastasis and multidrug resistance via dual blockade of MET/ABCB1 in colorectal carcinoma cells
In this study, the anti-tumor activity and molecular mechanism of anlotinib in metastatic colorectal cancer (mCRC) was explored. The anti-angiogenesis, anti-metastasis, anti-proliferative, and anti-multidrug resistance efficacy of anlotinib were analyzed by using in vitro and in vivo models of human CRC cells. The results indicated that anlotinib boosted chemo-sensitivity of CRC cells, and restrained its proliferation. Besides the suppression of the MET signaling pathway, anlotinib also inhibited invasion and migration of CRC cells. Furthermore, anlotinib prevented VEGF-induced angiogenesis, N-cadherin (CDH2)-induced cell ...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Lin-Hai Yan, Di Zhang, Si-Si Mo, Hao Yuan, Xian-Wei Mo, Jin-Min Zhao Tags: Research Paper Source Type: research
Peripheral blood biomarkers predict immune-related adverse events in non-small cell lung cancer patients treated with pembrolizumab: a multicenter retrospective study
Conclusions: The findings suggest that considering the routine availability of blood cell count data before the initiation of treatment with pembrolizumab, it may be useful in identifying early-onset irAEs during the 6-weeks study period in clinical practice. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Saeka Egami, Hitoshi Kawazoe, Hironobu Hashimoto, Ryuji Uozumi, Toko Arami, Naomi Sakiyama, Yuichiro Ohe, Hideo Nakada, Tohru Aomori, Shinnosuke Ikemura, Koichi Fukunaga, Masakazu Yamaguchi, Tomonori Nakamura Tags: Research Paper Source Type: research
Laparoscopic gastrectomy reduces adverse postoperative outcomes and decreases morbidity for gastric cancer patients with visceral obesity: a propensity score-matched analysis
Conclusions: Compared with open radical gastrectomy, laparoscopy would reduce the rate of postoperative complications in patients with VO, as well as prolong their overall survival. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Chenchen Mao, Xiaodong Chen, Xiangwei Sun, Xiang Wang, Ce Zhu, Wenjing Chen, Xiangyang Xue, Xian Shen Tags: Research Paper Source Type: research
