Impact of chemotherapy on lymphocytes and serological memory in recovered COVID-19 patients with acute leukemia
This study characterized the changes in immune cells and SARS-CoV-2 antibodies in acute leukemia patients, who underwent chemotherapy after recovering from COVID-19. The study enrolled three groups of individuals. One group was a total of three acute leukemia patients, who recovered well from COVID-19 before the last cycle of chemotherapy. The other two groups were six COVID-19 recovered healthy people, and six normal uninfected healthy people, respectively. Levels of B cells, T cells, and NK cells in peripheral blood were analyzed by multiparameter flow cytometry. Besides, the SARS-CoV-2 antibodies were monitored. The res...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Wei Liu, Ziping Li, Wenjuan He, Dan Yu, Ping Wang, Li Cai, Peng Yang, Xuexing Chen, Xiaoping Zhang, Hao Zhou Tags: Research Paper Source Type: research
Insights into the role of ERp57 in cancer
Endoplasmic reticulum resident protein 57 (ERp57) has a molecular weight of 57 kDa, belongs to the protein disulfide-isomerase (PDI) family, and is primarily located in the endoplasmic reticulum (ER). ERp57 functions in the quality control of nascent synthesized glycoproteins, participates in major histocompatibility complex (MHC) class I molecule assembly, regulates immune responses, maintains immunogenic cell death (ICD), regulates the unfolded protein response (UPR), functions as a 1,25-dihydroxy vitamin D3 (1,25(OH)2D3) receptor, regulates the NF-κB and STAT3 pathways, and participates in DNA repair processes and ...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Danyang Song, Hao Liu, Jian Wu, Xiaoliang Gao, Jianyu Hao, Daiming Fan Tags: Review Source Type: research
YTHDF1 gene polymorphisms and neuroblastoma susceptibility in Chinese children: an eight-center case-control study
Neuroblastoma is one of the most common life-threatening extracranial tumors that mainly occurs in children, and its genetic etiology remains largely obscure. RNA m6A modification has been thought to play a key role in cancer progression. YTHDF1 is the critical downstream gene by which RNA m6A modification exerts its functions. Single nucleotide polymorphisms in the YTHDF1 gene may affect its expression and biological activity, thereby leading to abnormalities in the regulation of downstream m6A-modified RNA and eventually promoting the initiation and development of tumors. Here, we attempted to evaluate the contributions ...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Jiabin Liu, Jiwen Cheng, Li Li, Yong Li, Haixia Zhou, Jiao Zhang, Suhong Li, Huimin Xia, Jing He, Zhonghua Yang Tags: Research Paper Source Type: research
Proteasome Complexes and Their Heterogeneity in Colorectal, Breast and Pancreatic Cancers
In this study, we used an optimized iodixanol gradient ultracentrifugation to purify a native form of proteasome complexes with their intact associated protein partners enriched within distinct cellular compartments. It is therefore possible to isolate proteasome subcomplexes with far greater resolution than sucrose or glycerol fractionations. We have identified differences in the catalytic activities, subcellular distribution, and inhibitor sensitivity of cytoplasmic proteasomes isolated from human colon, breast, and pancreatic cancer cell lines. Our developed techniques and generated results will serve as a valuable guid...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Diana Zagirova, Rebecca Autenried, Morgan E. Nelson, Khosrow Rezvani Tags: Research Paper Source Type: research
Impact of transformation on the survival of patients diagnosed with follicular lymphoma that progressed within 24 months
Conclusions: Transformation negatively impacted survival among FL patients more than POD24 itself. With caution, our findings suggest that BR may reduce POD24 more than RCVP or RCHOP. However, BR efficacy may not reduce the occurrence of transformation. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Sang Eun Yoon, Junhun Cho, Won Seog Kim, Seok Jin Kim Tags: Research Paper Source Type: research
Diagnostic roles of proliferative markers in pathological Grade of T1 Urothelial Bladder Cancer
In conclusion, MI and Ki-67, as important markers of histopathology and cell proliferation, can be easily measured and have good reproducibility. These markers may be meaningful parameters for assigning the pathological grade of UBC. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Jianping Yang, Chunjun Li, Yong Tang, Fang Guo, Yu Chen, Wenqi Luo, Xiaoyu Chen, Yun Ma, Lixia Zeng Tags: Research Paper Source Type: research
Socioeconomic factors are associated with the prognosis of Thyroid Cancer
Conclusions: Socioeconomic factors, including insurance status, marital status, living area, and Yost index, were significant predictors for the survival of thyroid adenomas/adenocarcinomas. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Yu Li, Da Huang, Baoxin Wang, Wei Mao, Xinwei Chen, Pin Dong Tags: Research Paper Source Type: research
Has the increase in the regional nodes evaluated improved survival rates for patients with locoregional colon cancer?
Conclusions: The golden period of surgical development in colon cancer, using RNE as an alternative indicator, occurred in the first decade of the 21st century. Although a more extensive lymph node evaluation is able to reduce the risk of underestimated staging, the increase of RNE does not provide survival benefits for locoregional colon cancer. A proper reduction in the scope of lymph node dissection may be reasonable in radical surgery for colon cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Zhongyi Zhou, Hong Zhu, Wenxue Liu, Fengbo Tan, Qian Pei, Lilan Zhao, Chenglong Li, Dan Wang, Yuan Zhou, Huan Peng, Haiping Pei, Yuqiang Li Tags: Research Paper Source Type: research
Exosome in Hepatocellular Carcinoma: an update
Hepatocellular carcinoma (HCC) is a common malignant tumor in the digestive tract with limited therapeutic choices. Intercellular communication among cancer cells and their microenvironment is crucial to disease progression. Exosomes are extracellular vesicles secreted by multiple types of cells into the extracellular space, which contain a variety of active components of secretory cells, including lipids, proteins, RNA and DNA. This vesicle structure involves in the exchange of materials and information between cells and plays an important role in the development of many diseases. Studies have shown that exosomes particip...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Wei Chen, Yinqi Mao, Chenbin Liu, Han Wu, Shuying Chen Tags: Review Source Type: research
Systematic analysis of the function and prognostic value of RNA binding proteins in Colon Adenocarcinoma
Conclusion: This study constructed a reliable prognostic model by analyzing COAD differentially expressed RBPs, facilitating the screening of COAD prognostic markers and therapeutic targets. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Xuewei Qi, Zeyu Liu, Qiaoli Zhang, Ming Yang, Yuxiang Wan, Jinchang Huang, Lin Xu Tags: Research Paper Source Type: research
Overexpression of ERCC3 is associated with poor prognosis in patients with pancreatic cancer
This study aimed to investigate the expression and functions of ERCC3 in pancreatic cancer patients and its relation with clinicopathological features. Our data suggested that the protein expression level of ERCC3 was higher in tumor tissues than in adjacent tissues. In addition, the expression of ERCC3 has shown to be associated with the tumor extent (p=0.035). Besides, analysis of the dataset in The Cancer Genome Atlas (TCGA) revealed that high expression of ERCC3 was associated with poor overall survival in pancreatic cancer patients (p=0.0136). In Cox regression analysis, ERCC3 was an independent prognostic factor for ...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Shujie Wang, Wenjing Liu, Yueli Ni, Lifeng Wang, Yuzhi Zhu, Qiong Shi, Zihan Yi, Wenjie Wang, Lili Liu, Lijuan Yang, Yingmin Kuang, Yuechun Zhu, Qiao Zhang, Zhe Yang Tags: Research Paper Source Type: research
Intratumoral Treatment with Chemotherapy and Immunotherapy for NSCLC with EBUS-TBNA 19G
Conclusions: Intratumoral treatment combination with cisplatin plus immunotherapy indifferent of nivolumab or pembrolizumab combination is an effective choice. In specific for those with endobronchial lesions. Moreover; patients with programmed death-ligand-1 ≥ 50 had their performance status and disease progression improved over the eight month observation. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Paul Zarogoulidis, Wolfgang Hohenforst-Schmidt, Haidong Huang, Jun Zhou, Qin Wang, Xiangqi Wang, Ying Xia, Yinfeng Ding, Chong Bai, Christoforos Kosmidis, Konstantinos Sapalidis, Chrysanthi Sardeli, Kosmas Tsakiridis, Bojan Zaric, Tomi Kovacevic, Vladimir Tags: Research Paper Source Type: research
Protein kinase PIM2: A simple PIM family kinase with complex functions in cancer metabolism and therapeutics
PIM2 (proviral integration site for Moloney murine leukemia virus 2) kinase plays an important role as an oncogene in multiple cancers, such as leukemia, liver, lung, myeloma, prostate and breast cancers. PIM2 is largely expressed in both leukemia and solid tumors, and it promotes the transcriptional activation of genes involved in cell survival, cell proliferation, and cell-cycle progression. Many tumorigenic signaling molecules have been identified as substrates for PIM2 kinase, and a variety of inhibitors have been developed for its kinase activity, including SMI-4a, SMI-16a, SGI-1776, JP11646 and DHPCC-9. Here, we summ...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Yixin Wang, Jing Xiu, Chune Ren, Zhenhai Yu Tags: Review Source Type: research
Circadian rhythm-associated clinical relevance and Tumor Microenvironment of Non-small Cell Lung Cancer
Conclusion: We identified and validated a circadian rhythm signature to described clinical relevance and tumor microenvironment of NSCLC, which revealed that circadian rhythms might play an influential role in the NSCLC. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Ming Li, Zhencong Chen, Tian Jiang, Xiaodong Yang, Yajing Du, Jiaqi Liang, Lin Wang, Junjie Xi, Miao Lin, Mingxiang Feng Tags: Research Paper Source Type: research
TTC36 inactivation induce malignant properties via Wnt- β -catenin pathway in gastric carcinoma
Conclusion: These results signify a critical role for TTC36 as a tumor suppressor in gastric carcinoma via regulating Wnt-β-catenin pathway. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Lei Song, Xiaonong Guo, Fei Zhao, Wei Wang, Zhifang Zhao, Long Jin, Chengli Wu, Jibin Yao, Zhongren Ma Tags: Research Paper Source Type: research
