Rural-urban difference in colorectal cancer mortality
(Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Tomoya Urakawa, Akihiro Saitsu, Jun Watanabe, Kazuhiko Kotani Tags: Commentary Source Type: research
ZFPM2-AS1 transcriptionally mediated by STAT1 regulates thyroid cancer cell growth, migration and invasion via miR-515-5p/TUSC3
Conclusion: ZFPM2-AS1 acted as an oncogene in thyroid cancer, which was transcriptionally mediated by STAT1. Furthermore, ZFPM2-AS1 weakened the inhibitory effect of miR-515-5p on TUSC3. Thus, ZFPM2-AS1 could be an underlying biomarker for thyroid cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Ruizhen Ren, Yuanna Du, Xing Niu, Rukun Zang Tags: Research Paper Source Type: research
Prognostic Value of Peripheral Blood Lymphocyte/monocyte Ratio in Lymphoma
Conclusion: Low LMR in peripheral blood indicates poor prognosis in patients with lymphoma. As a simple clinical indicator, peripheral blood LMR combined with existing prognostic factors can improve the accuracy of lymphoma prognosis assessment. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Feiqiong Gao, Jianlai Hu, Jiawei Zhang, Yang Xu Tags: Research Paper Source Type: research
Acidic extracellular pH induces autophagy to promote anoikis resistance of hepatocellular carcinoma cells via downregulation of miR-3663-3p
Metastasis is the major reason for poor prognosis and high fatality in hepatocellular carcinoma (HCC). Due to the “Warburg effect”, an acidic tumor microenvironment (TME) exists in solid tumors and plays a critical role in cancer metastasis. Thus, clarifying the mechanism underlying the acidic TME in tumor metastasis could facilitate the development of new therapeutic strategies for HCC. Anoikis resistance is one of the most important events in the early stage of cancer metastasis. Here, we report that acidic extracellular pH (pHe) promotes autophagy of HCC cells via the AMPK/mTOR pathway. We found that autopha...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Siying Wang, Yuanyuan Lv, Yangyang Zhou, Jing Ling, Hui Wang, Dishui Gu, Cun Wang, Wenxin Qin, Xingling Zheng, Haojie Jin Tags: Research Paper Source Type: research
Computerized Assessment of the Tumor-stromal Ratio and Proposal of a Novel Nomogram for Predicting Survival in Invasive Breast Cancer
Conclusions: Based on IHC staining of CK on TMAs, this study successfully developed a computerized method for TSR assessment and established a novel nomogram for predicting survival in invasive BC patients. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Xu Qian, Feng Xiao, Yuan-Yuan Chen, Jing-Ping Yuan, Xiao-Hong Liu, Lin-Wei Wang, Bin Xiong Tags: Research Paper Source Type: research
Homer2 and Homer3 Act as Novel Biomarkers in Diagnosis of hepatitis B virus-induced Hepatocellular Carcinoma
Conclusion: Our data indicated that Homer2 and Homer3 were downregulated in HCC and might be potential diagnostic marker for HCC. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Ping Luo, Chunzi Liang, Wei Jing, Man Zhu, Hu Zhou, Hongyan Chai, Paul F. Worley, Jiancheng Tu Tags: Research Paper Source Type: research
Intrahepatic Cholangiocarcinoma Cells Promote Epithelial-mesenchymal Transition of Hepatocellular Carcinoma Cells by Secreting LAMC2
Hepatocellular carcinoma and intrahepatic cholangiocarcinoma cells are common primary hepatic tumor cells in the liver. Combined hepatocellular cholangiocarcinoma (CHC) contains both hepatocellular carcinoma cells and intrahepatic cholangiocarcinoma cells in one tumor lesion and these tumors show poor prognosis. Here we examined the potential interaction between hepatocellular carcinoma cells and intrahepatic cholangiocarcinoma cells using cell culture studies. The results showed that culture supernatant from intrahepatic cholangiocarcinoma cells induced endothelial-mesenchymal transition and facilitated the migration and ...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Wenda Cen, Jiandong Li, Chenhao Tong, Weiguang Zhang, Yunfeng Zhao, Baochun Lu, Jianhua Yu Tags: Research Paper Source Type: research
IGHG1 induces EMT in gastric cancer cells by regulating TGF- β /SMAD3 signaling pathway
Conclusions: IGHG1 induces EMT in SGC7901 cells by regulating the TGF-β/SMAD3 signaling pathway. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Yuxuan Li, Pan Wang, Dongmei Ye, Xue Bai, Xuemei Zeng, Qiang Zhao, Zhiwei Zhang Tags: Research Paper Source Type: research
The Effects of Lentivirus-Mediated Gene Silencing of RAR β on the Stemness Capability of Non-Small Cell Lung Cancer
This study aimed to understand the role of RARβ in regulating cell growth and differentiation of lung cancer stem cells. Based on the clonogenic assay, spheroid assay, mRNA levels of stem cell transcription factors, and cell cycle being arrested at the G0/G1 phase, the suppression of RARβ resulted in significant inhibition of A549 parental cell growth. This finding was contradictory to the results seen in CSCs, where RARβ inhibition enhanced the cell growth of putative and non-putative CSCs. These results suggest that RARβ suppression may act as an essential regulator in A549 parental cells, but not in ...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Noor Hanis Abu Halim, Norashikin Zakaria, Kumitaa Theva Das, Juntang Lin, Moon Nian Lim, Kamal Shaik Fakiruddin, Badrul Hisham Yahaya Tags: Research Paper Source Type: research
SOX4 as biomarker in hepatitis B virus-associated hepatocellular carcinoma
Conclusion: Differential SOX4 expression presents an avenue of diagnosing and predicting clinical course of HCC. In HCC, SOX4 may affect TP53 metabolic processes, lymphocyte differentiation and the insulin signaling pathway. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Jian-Lv Huang, Xiang-Kun Wang, Xi-Wen Liao, Chuang-Ye Han, Ting-Dong Yu, Ke-Tuan Huang, Cheng-Kun Yang, Xiao-Guang Liu, Long Yu, Guang-Zhi Zhu, Hao Su, Wei Qin, Quan-Fa Han, Zheng-Qian Liu, Xin Zhou, Jun-Qi Liu, Xin-Ping Ye, Tao Peng Tags: Research Paper Source Type: research
Characteristics of Infiltrating Immune Cells and a Predictive Immune Model for Cervical Cancer
The role of infiltrating immune cells within the tumor microenvironment has received considerable attention, but their function in cervical cancer remains to be elucidated; thus, comprehensive evaluation of their predictive value is needed. Using cervical cancer samples from 406 patients, immune cell infiltration was evaluated via immunohistochemistry. CD3+, CD4+, CD8+, CD20+, CD57+, CD68+, and CD163+ cell infiltration was compared in samples from adjacent tissues and the tumor center. The associations between immune cell distributions in the tumor center, clinicopathological features, and prognosis were correlated among i...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Ruanmin Zou, Ruihong Gu, Xia Yu, Yingying Hu, Junhui Yu, Xiangyang Xue, Xueqiong Zhu Tags: Research Paper Source Type: research
Specific MiRNAs in na ï ve T cells associated with Hepatitis C Virus-induced Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the fifth most common type of cancer and the second leading cause of cancer-associated mortality worldwide. Hepatitis C virus (HCV) infection is the primary cause of hepatic fibrosis and cirrhosis, which in turn, notably increase the risk of developing HCC. The systematic immune response plays a vital role in protecting eukaryotic cells from exogenous antigens. In the present study, to determine the association between T cells and miRNAs in HCV-induced HCC (HCV-HCC), bulk mRNA and miRNA sequencing data from HCV-HCC tissues were combined, along with single-cell RNA sequencing (RNA-seq) data...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Peng Yan, Pengfei Pang, Xiaojun Hu, Ani Wang, Huitao Zhang, Yingdong Ma, Ke Zhang, Yaochao Ye, Bin Zhou, Junjie Mao Tags: Research Paper Source Type: research
The role of chemotherapy in patients with T1bN0M0 triple-negative breast cancer: a real-world competing risk analysis
The objective of the present study was to implement Kaplan-Meier analysis, competing risk analysis, and propensity score matching to evaluate whether the patients with T1bN0M0 triple-negative breast (TNBC) could benefit from adjuvant chemotherapy. A total of 1849 patients were identified in the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. All eligible patients were divided into two cohorts, the chemotherapy (1155 patients) and the no-chemotherapy (694 patients) cohorts. Similar 5-year breast cancer-specific survival (BCSS) was observed in the chemotherapy and no-chemotherapy cohorts (96.1%...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Tian Lan, Yunyan Lu, Hua Luo, Ouou Yang, Junling He, Haibin Xu, Zujian Hu Tags: Research Paper Source Type: research
Clinical value of docetaxel plus cisplatin (TP) induction chemotherapy followed by TP concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma
Conclusion: TP + TP can reduce the distant metastasis of locoregionally advanced NPC and improve OS compared with TP + DDP; TP + TP has the same effect as TPF + DDP and is clinically feasible. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Hao-Yun Tao, Ze-Jiang Zhan, Wen-Ze Qiu, Kai Liao, Ya-Wei Yuan, Tai-Ze Yuan, Rong-Hui Zheng Tags: Research Paper Source Type: research
The Essential Factors of Establishing Patient-derived Tumor Model
Establishing an applicable preclinical model is vital for translational cancer research. Patient-derived xenograft has been important preclinical model systems and widely used for cancer research. Patient-derived xenograft models that represent the tumors of the patients are necessary to better translate research discoveries and to test potential therapeutic approaches. However, research in this field is hampered by the limited engraftment rate. In this review, we go over a large number of researches on patient-derived xenograft transplantation and firstly systematically summarize the main factors in methodology to success...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Chuanzhi Chen, Wu Lin, Yingying Huang, Xiangliu Chen, Haohao Wang, Lisong Teng Tags: Review Source Type: research
