Cytokine-induced killer cells carrying recombinant oncolytic adenovirus expressing p21Ras scFv inhibited liver cancer
Conclusions: We develop a novel strategy for the treatment of Ras-driven liver cancer by combining CIK cells with oncolytic adenovirus expressing anti-p21Ras scFv. Intravenous injection of CIK cells carrying KGHV500 in vivo significantly inhibits tumor growth, has little effect on normal organs, and is relatively safe. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Fang Dai, Peng-Bo Zhang, Qiang Feng, Xin-Yan Pan, Shu-Ling Song, Jing Cui, Ju-Lun Yang Tags: Research Paper Source Type: research
The Expression of Transcription Factors is Different in Papillary Thyroid Cancer Cells during TNF - α induced EMT
Proinflammatory factor tumor necrosis factor-α (TNF-α) is an important inflammatory mediators in tumor microenvironment and autoimmune diseases, it is highly expressed in many solid tumors and tumor microenvironment, showing a tumor promoting role. However, the molecular mechanisms underlying TNF-α-increased invasion of thyroid cancer are still not fully understood. In order to explore whether TNF-α plays a key role in the process of epithelial mesenchymal transition (EMT) in papillary thyroid carcinoma (PTC), we used TNF-α to induce EMT in different PTC cell lines, and observed the expression of d...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Nannan Lv, Fei Liu, Lan Cheng, Feng Liu, Jinsong Kuang Tags: Research Paper Source Type: research
Lignans intake and enterolactone concentration and prognosis of breast cancer: a systematic review and meta-analysis
Conclusion: This study provides limited evidence that lignans intake and higher serum enterolactone concentrations in postmenopausal women are beneficial to breast cancer patients' prognosis. In premenopausal women, however, the relationship may be reversed. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Zhen Liu, Yin-Jiao Fei, Xin-Hui Cao, Di Xu, Wen-Juan Tang, Kai Yang, Wen-Xiu Xu, Jin-Hai Tang Tags: Research Paper Source Type: research
CSE1L, as a novel prognostic marker, promotes pancreatic cancer proliferation by regulating the AKT/mTOR signaling pathway
Pancreatic cancer is one of the most aggressive tumors with poor prognosis and new targetable therapies are urgently required. CSE1L (chromosome segregation 1 like) is thought to play an important role in tumorigenesis and acts as a cancer therapeutic target. However, the biological function and the underlying mechanism of CSE1L in pancreatic cancer are still not fully explicit. In the present study, we found that high CSE1L expression was related to a worse prognosis in patients with pancreatic cancer according to data from the Cancer Genome Atlas (TCGA) database. Additionally, we found that CSE1L knockdown inhibited the ...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Xiao Zhang, Xiaofei Zhang, Tiebo Mao, Haiyan Xu, Jiujie Cui, Hechun Lin, Liwei Wang Tags: Research Paper Source Type: research
The relationship between the severity of pulmonary fibrosis and the lung cancer stage
Conclusions: The lung cancer stage at diagnosis was higher in patients with a higher GAP stage than in those with a lower GAP stage. Physicians should consider implementing more frequent surveillance with computed tomography scans for patients with advanced IPF. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Hye Jin Jang, Moo Suk Park, Young Sam Kim, Joon Chang, Jae Ho Lee, Choon-Taek Lee, Sang Hoon Lee, Ho Il Yoon Tags: Research Paper Source Type: research
Efficient combination of Human Papillomavirus Genotyping for the triage of women with Atypical Squamous Cells of Undetermined Significance in Chinese rural population: A population-based study
Conclusion: Our results demonstrate that genotyping for a combination of HPV16/18/31/33/58 provides a more efficient and cost-effective model to risk-stratify women with ASC-US in the Chinese rural population. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Wei Wang, Huina Zhang, Leqian Lin, Aimin Yang, Jing Yang, Weihong Zhao, Zhilian Wang, Lili Zhang, Xiaoqiang Su, Zhe Wang, Chen Wang, Haitao Zhang, Bo Feng, Dongyan Li, Huiqiang Liu, Xiaofen Niu, Jintao Wang, Jinghui Song, Li Li, Weiguo Lv, Chengquan Zhao, Tags: Research Paper Source Type: research
Exosomal miR-1305 in the oncogenic activity of hypoxic multiple myeloma cells: a biomarker for predicting prognosis
Conclusions: Exosome-mediated secretion of miR-1305 in MM cells promoted oncogenic activity of hypoxic MM cells and high serum levels of exosomal miR-1305. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Ji Young Lee, Daeun Ryu, Sung Won Lim, Kyung Ju Ryu, Myung Eun Choi, Sang Eun Yoon, Kihyun Kim, Chaehwa Park, Seok Jin Kim Tags: Research Paper Source Type: research
Auxiliary diagnosis of Lung Cancer on the basis of a Serum Protein Biomarker Panel
Conclusions: It was demonstrated that 4-protein biomarker panel had a significant performance in identifying lung cancer patients from healthy controls, especially combining with the nodule size. Specifically, it yielded excellent discrimination for identifying early-stage lung cancer patients than individual biomarker alone. A future large-scale study is underway to further define the clinical application of this method for the early diagnosis of lung cancer among Chinese populations. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Qiong Lu, Zhongwei Jia, Junli Gao, Meijuan Zheng, Junshun Gao, Mingjie Tong, Jinxing Xia, Fang Li, Baoling Yang, Lili Zhang, Bo Wang, Rui Wang, Jinping Qiao, Qinqin Lou, Jinbo Gao, Yuanhong Xu Tags: Research Paper Source Type: research
Grape Seed Proanthocyanidins play the roles of radioprotection on Normal Lung and radiosensitization on Lung Cancer via differential regulation of the MAPK Signaling Pathway
This study was to investigate radioprotective effects of grape seed proanthocyanidins (GSP) on normal lung as well as radiosensitizing effects on lung cancer. In vitro, we demonstrated radioprotective effects of GSP on normal alveolar epithelial cells (MLE-12 and BEAS/2B) and radiosensitizing effects on lung cancer cells (LLC and A549). In vivo, we confirmed these two-way effects in tumor-bearing mice. The results showed that GSP inhibited tumor growth, and played a synergistic killing effect with radiotherapy on lung cancer. Meanwhile, GSP reduced radiation damage to normal lung tissues. The two-way effects related to the...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Yang Xu, Yijuan Huang, Yuanyuan Chen, Kun Cao, Zhe Liu, Zhijie Wan, Zebin Liao, Bailong Li, Jianguo Cui, Yanyong Yang, Xiaohua Xu, Jianming Cai, Fu Gao Tags: Research Paper Source Type: research
Age, Gender and Geographic Differences in Global Health Burden of Cirrhosis and Liver Cancer due to Nonalcoholic Steatohepatitis
Conclusion: The global burden of NASH-associated liver cancer has increased significantly since 1990, with age, gender and geographic disparity. Public awareness of liver diseases due to NASH should be emphasized. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Tianyue Zhang, Jingya Xu, Lingxia Ye, Xiling Lin, Yufeng Xu, Xiaowen Pan, Xifang Weng, Chuyu Ye, Longjiang Fan, Yuezhong Ren, Peng-Fei Shan Tags: Research Paper Source Type: research
A Novel Immunotype-based Risk Stratification Model Predicts Postoperative Prognosis and Adjuvant TACE Benefit in Chinese Patients with Hepatocellular Carcinoma
Conclusion: A novel immunotype-based risk stratification model was built to predict postoperative prognosis and adjuvant TACE benefit in HCC patients. These tools can assist in building a more customized method of HCC treatment. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Tian-En Li, Ze Zhang, Yi Wang, Da Xu, Jian Dong, Ying Zhu, Zheng Wang Tags: Research Paper Source Type: research
Application of machine learning in prediction of Chemotherapy resistant of Ovarian Cancer based on Gut Microbiota
Conclusions: The diversity of gut microbiota was higher in OC patients with chemotherapy resistance. Further studies are warranted to validate our findings based on machine learning techniques. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Ting-Ting Gong, Xin-Hui He, Song Gao, Qi-Jun Wu Tags: Research Paper Source Type: research
Tumor-associated macrophages are associated with response to neoadjuvant chemotherapy and poor outcomes in patients with triple-negative breast cancer
Conclusions: our data showed that TAMs may predict chemotherapeutic response and can be used as a promising prognostic candidate for poor survival in TNBC patients treated with NAC. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Jia-hui Ye, Xiao-hua Wang, Jia-jun Shi, Xi Yin, Cheng Chen, Yan Chen, Hong-Yan Wu, Shi Jiong, Qi sun, Meng Zhang, Xian-biao Shi, Guo-ren Zhou, Shahzeb Hassan, Ji-feng Feng, Xin-yun Xu, Wei-jie Zhang Tags: Research Paper Source Type: research
Changes in phospholipid metabolism in exosomes of hormone-sensitive and hormone-resistant prostate cancer cells
Conclusions: This study demonstrates that phosphatidylcholine and its harmful product lysophosphatidylcholine may play important roles in hormone-sensitive prostate cancer. Phospholipid exosome metabolism was changed in hormone-sensitive and hormone-resistant prostate cancer cells. The LPC, lipid pathway of autophagy and ferroptosis may act as therapeutic targets. The possibility of purifying prostate cancer cell exosomes using modified PEG precipitation is suitable for cancer screening. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Xianlin Yi, You Li, XiaoGang Hu, FuBing Wang, Tiangang Liu Tags: Research Paper Source Type: research
Clinical characteristics and outcomes in HIV-associated diffuse large B-cell lymphoma in China: A retrospective single-center study
Human immunodeficiency virus (HIV) infection is associated with an increased risk of aggressive lymphoma, especially diffuse large B cell lymphoma (DLBCL). There are few data regarding HIV-associated DLBCL in China. Therefore, we analyzed the characteristics and outcomes of patients with HIV-associated DLBCL from our center. We retrospectively studied HIV-infected patients with DLBCL from 2011 to 2019. Data on HIV infection and lymphoma characteristics, treatments and outcomes were retrieved and analyzed. In 78 patients with HIV-associated DLBCL, most had poor performance status (PS) (74%), elevated lactate dehydrogenase (...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Jiazhu Wu, Yi Miao, Chuan Qian, Pengfei Tao, Xicheng Wang, Xingqi Dong, Xia Li, Jincheng Lou, Jinhua Liang, Wei Xu, Jianyong Li, Haiyan Min Tags: Research Paper Source Type: research
