Histological, epidemiological and anatomical analysis of 193 bone tumours of the scapula
ConclusionsEvaluation of 193 bone tumours of the scapula revealed a high incidence of malignancy in this series, while increased patient age was identified as a potential risk factor for the development of a malignant lesion of the scapula. These findings highlight the importance of early diagnosis and treatment of suspicious lesions of the scapula to improve patient outcome. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - August 24, 2019 Category: Cancer & Oncology Source Type: research
Intra-articular osteoid osteoma accompanied by extensive bone marrow edema. A clinical and micro-morphological analysis
In this study, a consecutive series of four patients suffering from extensive bone marrow edema triggered by intra-articular osteoid osteoma underwent clinical examination, magnetic resonance imaging (MRI) and computed tomography (CT) as well as dual-energy X-ray absorptiometry (DXA) and laboratory bone turnover analyses. The obtained resection specimens were processed by undecalcified histology and were subsequently analyzed by light microscopy and quantitative backscattered electron imaging (qBEI). We report an entity of intra-articular osteoid osteoma in the knee and foot, in which an extensive and persistent bone marro...
Source: Journal of Bone Oncology - August 21, 2019 Category: Cancer & Oncology Source Type: research
Mouse Model Recapitulates the Phenotypic Heterogeneity of Human Adult T-cell Leukemia/Lymphoma in Bone
Publication date: Available online 20 August 2019Source: Journal of Bone OncologyAuthor(s): Nicole A. Kohart, Said M. Elshafae, Wachirapan Supsahvad, Aylin Alasonyalilar-Demirer, Amanda R. Panfil, Jingyu Xiang, Wessel P. Dirksen, Deborah J. Veis, Patrick L. Green, Katherine N. Weilbaecher, Thomas J. RosolAbstractAdult T-cell leukemia/lymphoma has a unique relationship to bone including latency in the marrow, and development of bone invasion, osteolytic tumors and humoral hypercalcemia of malignancy. To study these conditions, we established and characterized a novel mouse model of ATL bone metastasis. Patient-derived ATL c...
Source: Journal of Bone Oncology - August 21, 2019 Category: Cancer & Oncology Source Type: research
Denosumab for bone health in prostate and breast cancer patients receiving endocrine therapy? A systematic review and a meta-analysis of randomized trials
In conclusion, Denosumab administration can be considered effective and safe in the prevention and management of the above mentioned adverse events related to hormonal therapies designed for breast and prostate tumors. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - August 9, 2019 Category: Cancer & Oncology Source Type: research
Chondroblastoma in pelvis and extremities- a signle centre study of 177 cases
ConclusionsChondroblastoma is a rare benign to intermediate grade bone tumour with a potential to metastasise. Femoral head chondroblastoma is rare, presenting 4.5% of all chondroblastoma cases. Around 50% of the chondroblastoma in femoral head. occur in patients with open growth plates. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - August 6, 2019 Category: Cancer & Oncology Source Type: research
Aneurysmal bone cyst: a review of 65 patients
ConclusionCurettage is still the standard of treatment for ABC. Local recurrence does not depend on the use of adjuvant phenol as shown in this and other studies. Minimally invasive methods such as selective embolization and injections of sclerosing agents may result in healing or at least in tolerable persistence of residual lesions but needs repetitive treatments and does not show homogenous results throughout the institutions. Denosumab appears to be an additional option, especially in surgically critical locations such as the spine or the sacrum. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - August 6, 2019 Category: Cancer & Oncology Source Type: research
Incidence of fractures in young women with breast cancer - a retrospective cohort study
In conclusion, premenopausal women with BC with or without tamoxifen treatment had an increased incidence of fractures compared to healthy women, but this difference was only significant when comparing tamoxifen users versus healthy women. More studies are needed to identify the specific risk factors of women at high risk. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 26, 2019 Category: Cancer & Oncology Source Type: research
Prediction and evaluation of neoadjuvant chemotherapy using the dual mechanisms of 99mTc-MIBI scintigraphy in patients with osteosarcoma
Conclusion99mTc-MIBI imaging is a useful tool for the evaluation of neoadjuvant chemotherapy in patients with osteosarcoma, and its dual mechanisms could be simultaneously used in predicting and evaluating tumor response to chemotherapy. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 23, 2019 Category: Cancer & Oncology Source Type: research
The role of CXCR4 in Multiple Myeloma: Cells’ Journey from Bone Marrow to Beyond
Publication date: Available online 16 July 2019Source: Journal of Bone OncologyAuthor(s): Tomalika Rahmat UllahAbstractCXCR4 is a pleiotropic chemokine receptor which acts through its ligand CXCL12 to regulate diverse physiological processes. CXCR4/CXCL12 axis plays a pivotal role in proliferation, invasion, dissemination and drug resistance in multiple myeloma (MM). Apart from its role in homing, CXCR4 also affects MM cell mobilization and egression out of the bone marrow (BM) which is correlated with distant organ metastasis. Aberrant CXCR4 expression pattern is associated with osteoclastogenesis and tumor growth in MM t...
Source: Journal of Bone Oncology - July 17, 2019 Category: Cancer & Oncology Source Type: research
Is there a role for Denosumab and bone health for prostate and breast cancer patients undergoing endocrine therapy? A systematic review and a meta-analysis of randomized trials
In conclusion, Denosumab administration can be considered effective and safe in the prevention and management of the above mentioned adverse events related to hormonal therapies designed for breast and prostate tumors. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 17, 2019 Category: Cancer & Oncology Source Type: research
The dual mechanisms of 99mTc-MIBI scintigraphy were used to predict and evaluate neoadjuvant chemotherapy for osteosarcoma
Conclusion99mTc-MIBI imaging is a useful tool for the evaluation of neoadjuvant chemotherapy in patients with osteosarcoma, and it has the dual value of predicting and evaluating tumor response to chemotherapy. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 11, 2019 Category: Cancer & Oncology Source Type: research
The Homogeneous And Heterogeneous Risk Factors For Occurrence And Prognosis In Lung Cancer Patients With Bone Metastasis
ConclusionThe morbidity of bone metastasis in lung cancer patients is dismal, with a rate of 25.9%. The findings of this study estimate the homogeneous and heterogeneous risk factors for the occurrence and prognosis of bone metastasis in lung cancer patients, which may provide clinical guidelines for physicians.Graphical abstract (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 9, 2019 Category: Cancer & Oncology Source Type: research
Changing Landscape of Optical Imaging in Skeletal Metastases
Publication date: Available online 27 June 2019Source: Journal of Bone OncologyAuthor(s): Nicholas Cho, Monica ShokeenAbstractOptical imaging is an emerging strategy for in vitro and in vivo visualization of the molecular mechanisms of cancer over time. An increasing number of optical imaging contrast agents and techniques have been developed in recent years specifically for bone research and skeletal metastases. Visualizing molecular processes in relation to bone remodeling in metastasized cancers provides valuable information for understanding disease mechanisms and monitoring expression of primary molecular targets and ...
Source: Journal of Bone Oncology - June 28, 2019 Category: Cancer & Oncology Source Type: research
Chondroblastoma of bone in extremities. - A single centre study of 177 cases
ConclusionsChondroblastoma is a rare benign to intermediate grade bone tumour with a potential to metastasise. Femoral head chondroblastoma is rare, presenting 4.5% of all chondroblastoma cases. Around 50% of the chondroblastoma in femoral head. occur in patients with open growth plates. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - June 27, 2019 Category: Cancer & Oncology Source Type: research
Application of nomograms to predict overall and cancer-specific survival in patients with chordoma
Conclusion: Nomograms were constructed to predict overall survival and cancer-specific survival for patients with chordoma of the skull base, vertebral column, and pelvis. The nomogram could help surgeons to identify high risk of mortality and evaluate prognosis in patients with chordoma. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - June 25, 2019 Category: Cancer & Oncology Source Type: research
